Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo

Şahin, Ethem; Deveci, İldem; Dinç, Mehmet Emre; Özker, Berna Yayla; Bıçer, Cemile; Erel, Özcan

doi:10.5152/iao.2018.4756

Cited by 17 publications

(21 citation statements)

References 20 publications

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“…Authors have demonstrated that NT levels were significantly lower in patients with benign paroxysmal positional vertigo, seasonal allergic rhinitis, Bell's palsy, obstructive sleep apne and nasal polyposis [53][54][55][56][57].…”

Section: Head and Neck Pathologiesmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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Section: Head and Neck Pathologiesmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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“…In the present study, we found that there was significant difference in serum levels of SOD in the patients with BPPV before treatment vs. after treatment. However, one study found that the increase in oxidative stress did not respond to the treatments that were administered to patients with BPPV [17], and another study also showed that the levels of the antioxidant paraoxonase in patients with BPPV before and after treatment did not have obvious difference [19]. More further studies should be carried out to assess the role of treatment on the levels of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of inflammatory reaction and oxidative stress may play role in the occurrence of vascular vertigo and BPPV [15,17]. Several prior studies have explored the association between serum oxidative stress markers' concentrations and BPPV [19,28].…”

Section: Discussionmentioning

confidence: 99%

“…Benign paroxysmal positional vertigo (BPPV) is the most frequent peripheral vestibular disorder and is particularly seen among older patients suffering from vertigo [16]. BPPV includes two types: posterior semicircular canal (PSC) and horizontal semicircular canal (HSC) [17], and canalithiasis of the PSC might be caused in at least 85% of patients [18]. In a recent study, it has been revealed that calcium metabolism and its relationship with oxidative stress might play a role in the development of BPPV [19], while another study suggested a role of oxidative stress in the development of BPPV, through both calcium metabolism and the direct toxic effects of free oxygen radicals, including the triggering of apoptosis [17].…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

Xia

Wang

et al. 2020

Bioscience Reports

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Objective: To investigate the possible role of superoxide dismutases (SODs) in the development of benign paroxysmal positional vertigo (BPPV) and recurrence events in a 1-year follow-up study. Methods: This was a prospective one-center study. A total of 204 patients with BPPV and 120 age-and sex matched healthy subjects were included. The levels of SOD between patients and control cases were compared. The levels of SOD between posterior semicircular canal (PSC) and horizontal semicircular canal (HSC) were also compared. In the 1-year follow-up, recurrence events were confirmed. The influence of SOD levels on BPPV and recurrent BPPV were performed by binary logistic regression analysis. Results: The serum levels of SOD in patients with BPPV were lower than in those control cases (P<0.001). Levels of SOD did not differ in patients with PSC and HSC (P=0.42). As a categorical variable, for per interquartile range (IQR) increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 72% (with the odds ratio [OR] of 0.28 [95% confidence interval (CI): 0.21–0.37], P<0.001) and 43% (0.57 [0.42–0.69], P<0.001), respectively. Recurrent attacks of BPPV were reported in 50 patients (24.5%). Patients with recurrent BPPV had lower levels of SOD than in patients without (P<0.001). For per IQR increment of serum level of SOD, the unadjusted and adjusted risks of BPPV would be decreased by 51% (with the OR of 0.49 [95% CI: 0.36–0.68], P<0.001) and 24% (0.76 [0.60–0.83], P<0.001), respectively. Conclusion: Reduced serum levels of SOD were associated with higher risk of BPPV and BPPV recurrence events.

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“…Accumulated studies evidenced that the CSD is mainly triggered neuro-otologic and psychiatric disorders 13,19,20 . Furthermore, recent studies reported that the above pathological alterations are deeply related to the oxidative stress in clinical practice and animal based in vivo experiment [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of Oxidative Stress and Endogenous Antioxidants for Patients with Chronic Subjective Dizziness

Fang

Huang

Gil

et al. 2020

Sci Rep

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As a neurotologic disorder of persistent non-vertiginous dizziness, chronic subjective dizziness (CSD) arises unsteadily by psychological and physiological imbalance. The CSD is hypersensitivity reaction due to exposure to complex motions visual stimuli. However, the pathophysiological features and mechanism of the CSD still remains unclearly. The present study was purposed to establish possible endogenous contributors of the CSD using serum samples from patients with the CSD. A total 199 participants were gathered and divided into two groups; healthy (n = 152, male for 61, and female for 91) and CSD (n = 47, male for 5, female for 42), respectively. Oxidative stress parameters such as, hydrogen peroxide and reactive substances were significantly elevated (p < 0.01 or p < 0.001), whereas endogenous antioxidant components including total glutathione contents, and activities of catalase and superoxide dismutase were significantly deteriorated in the CSD group (p < 0.01 or p < 0.001) as comparing to the healthy group, respectively. Serum levels of tumor necrosis factor -α and interferon-γ were significantly increased in the CSD participants (p < 0.001). Additionally, emotional stress related hormones including cortisol, adrenaline, and serotonin were abnormally observed in the serum levels of the CSD group (p < 0.01 or p < 0.001). Our results confirmed that oxidative stress and antioxidants are a critical contributor of pathophysiology of the CSD, and that is first explored to establish features of redox system in the CSD subjects compared to a healthy population.Since mid of two thousand years, chronic subjective dizziness (CSD) has been used as termination of medial field to explain the specific pathological conditions of persistent, non-vertiginous dizziness, subjective imbalance, and hypersensitivity to motion cues in the lack of active vestibular deficits 1,2 . The above symptoms of the CSD are often worsened with stimulation of visual environments or settings with indistinct visual orientation cues.Etiologically the CSD is mainly arisen from neurotologic or other pathological events including acute vertigo, unsteadiness, or dizziness, and they are corresponded to vestibular neuritis, pre-syncope, or panic attacks 3 . Some studies also revealed that approximately 25% of patients with the CSD experienced the above events, however underlying pathophysiological mechanisms are needed to reveal obscurely 4-6 .The main and general symptoms of the CSD are represented by emotional behaviors, therapeutic accesses are also very limited. Only some of treating methods are available including vestibular therapy 7 , cognitive behavioral therapy 8,9 , or selective serotonin reuptake inhibitors (SSRI) which was generally used to treat depression 1,2,10 , which is focusing on the relieving the main symptoms.

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Oxidative Status in Patients with Benign Paroxysmal Positional Vertigo

Abstract: Our results suggest a role of oxidative stress in the development of BPPV, through both calcium metabolism and the direct toxic effects of free oxygen radicals, including the triggering of apoptosis.

Cited by 17 publications

References 20 publications

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo

Biomarkers of Oxidative Stress and Endogenous Antioxidants for Patients with Chronic Subjective Dizziness

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