Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study

Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.

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“…The GSH/GSSG ratio was estimated according to the recently described method by Kovalčíková et al [ 27 ].…”

Section: Methodsmentioning

confidence: 99%

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

et al. 2022

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“…(11) Several studies showed that AN is associated with increased oxidative stress markers, with a decrease in these markers after weight gain. (21,22) Thus, this mechanism should be considered when formulating a hypothesis for the increase of ferritin in these patients.…”

Section: Discussionmentioning

confidence: 99%

“Serum ferritin – a nutritional marker for Anorexia Nervosa?”

Teixeira¹,

Luz²,

Coutinho³

et al. 2023

Braz. J. Hea. Rev.

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Introduction: A new marker that correlates with nutritional recovery in Anorexia Nervosa would be of great value. Our study aimed to analyse the influence of Body Mass Index variations on serum ferritin levels in adolescents with Anorexia Nervosa followed up in a specialised consultation. Methods: We conducted a retrospective, observational, single-centre study in adolescents with Anorexia Nervosa evaluated between 2011 and 2019. Serum ferritin values at baseline and during follow-up were analysed, together with the corresponding Body Mass Index (BMI) and Z-Score values. Further analytical data such as hematological and inflammatory markers were recorded. Results: The study included 53 adolescents with Anorexia Nervosa. Patients were found to have higher initial serum ferritin levels compared to the last, under treatment, assessed values (p<0.001). There was a significant increase in BMI and BMI Z-Score during follow-up (p<0.001), reflecting nutritional recovery. Analysing the variation of these values, we found a negative linear association between the variation of serum ferritin and the variation of BMI Z-Score (ß -0.1; R2 0,39; p<0,001). In analysing the change of BMI Z-Score and serum ferritin as a function of time, a linear regression model was used (ß -0,39; R2 0,12; p <0,001), showing that the quicker the recovery of BMI Z-Score, the faster the decrease in ferritin value. None of the patients presented anaemia, and in most cases, the other inflammatory markers remained normal. Conclusion: Serum ferritin could be of value in the evaluation of patients with Anorexia Nervosa in the absence of other diseases, in particular when other markers of malnutrition are normal.

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“…Notably, the level of AGEs in the renal cortex was highest in the ZL rats that exhibited the lowest body weight. It was shown that AGEs are lipophilic and, thus, are preferentially stored in the fat tissue [ 25 ]. In the case of lower body fat content (typical of ZL rats in our experiment), AGEs could be stored in higher amounts in other tissues, e.g., in the renal cortex, as suggested by this study.…”

Section: Discussionmentioning

confidence: 99%

Na,K-ATPase Kinetics and Oxidative Stress in Kidneys of Zucker Diabetic Fatty (fa/fa) Rats Depending on the Diabetes Severity—Comparison with Lean (fa/+) and Wistar Rats

Vrbjar

Jasenovec

Kollárová

et al. 2022

Biology

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For a better insight into relations between type 2 diabetes mellitus (T2DM) and Na,K-ATPase properties in kidneys, we aimed to characterize two subgroups of ZDF obese (fa/fa) rats, with more and less developed T2DM, and compare them with two controls: lean (fa/+) and Wistar. Na,K-ATPase enzyme kinetics were estimated by measuring the ATP hydrolysis in the range of NaCl and ATP levels. As Na,K-ATPase is sensitive to oxidative stress, we evaluated selected oxidative stress parameters in kidney homogenates. Our results suggest that thiol–disulfide redox balance in the renal medulla and Na,K-ATPase properties in the renal cortex differ between both controls, while observed measurements in lean (fa/+) rats showed deviation towards the values observed in ZDF (fa/fa) rats. In comparison with both controls, Na,K-ATPase enzyme activity was higher in the renal cortex of ZDF rats independent of diabetes severity. This might be a consequence of increased glucose load in tubular fluid. The increase in lipid peroxidation observed in the renal cortex of ZDF rats was not associated with Na,K-ATPase activity impairment. Regarding the differences between subgroups of ZDF animals, well-developed T2DM (glycemia higher than 10 mmol/L) was associated with a higher ability of Na,K-ATPase to utilize the ATP energy substrate.

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Oxidative status in plasma, urine and saliva of girls with anorexia nervosa and healthy controls: a cross-sectional study

Cited by 8 publications

References 56 publications

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

“Serum ferritin – a nutritional marker for Anorexia Nervosa?”

Na,K-ATPase Kinetics and Oxidative Stress in Kidneys of Zucker Diabetic Fatty (fa/fa) Rats Depending on the Diabetes Severity—Comparison with Lean (fa/+) and Wistar Rats

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