The Role of Oxidative Stress in Atopic Dermatitis and Chronic Urticaria

Abstract

Atopic dermatitis (AD) and chronic urticaria (CU) are common skin diseases with an increasing prevalence and pathogenesis that are not fully understood. Emerging evidence suggests that oxidative stress plays a role in AD and CU. The aim of the single-center cross-sectional study was to compare markers of oxidative stress in 21 patients with AD, and 19 CU patients. The products of protein oxidation, total antioxidant capacity (TAC), and markers of lipid peroxidation were estimated in the serum. AD patients had a higher level of advanced protein oxidation products and a lower level of thiol groups than healthy participants. However, CU patients had statistically higher levels of AOPP and 3-nitrotyrosine than healthy subjects. The level of thiol groups and serum TAC decreased significantly in patients with CU. There was no difference in serum concentration of lipid peroxidation products, Amadori products, ratio of reduced to oxidized glutathione, and ability of albumin to binding cobalt between AD or CU patients compared to healthy subjects. We found a moderate positive significant correlation between AOPP and age in patients with AD. In patients with CU, TAC was negatively correlated with age. These results may shed light on the etiopathogenesis of AD or CU, and confirm an oxidative burden in these patients. Furthermore, our study could be useful in developing new therapeutic methods that include using antioxidants in dermatological diseases.

Cascade of atopic dermatitis comorbidities in children after birth for 15 years

“…28 Association between two diseases can be explained by immunological dysregulation, shared genetic factors, and oxidative stress. 29,30 Here, we found that atopic dermatitis had a stronger association with chronic urticaria and psoriasis than with asthma or allergic rhinitis, which is consistent with previous findings. 31 Although the association between atopic dermatitis and allergic comorbidities is well recognized, its association with autoimmune diseases is less clear and should be considered in the management and follow-up of children with atopic dermatitis.…”

“…A large, nationwide cross‐sectional study of adolescents showed that atopic dermatitis was associated with chronic urticaria (odds ratio: 2.35, 95% CI: 2.03–2.72) 28 . Association between two diseases can be explained by immunological dysregulation, shared genetic factors, and oxidative stress 29,30 . Here, we found that atopic dermatitis had a stronger association with chronic urticaria and psoriasis than with asthma or allergic rhinitis, which is consistent with previous findings 31 .…”

Lipid composition and peroxidation products in the body tissues in bees under the action of different doses of nanotechnological Ge citrate and the probiotic Lactobacillus casei В-7280

“…LPO products cause disruption of not only lipid bonds in biomembranes and their protein component -due to binding with amine groups, which leads to disruption of protein-lipid interaction. Free radical oxidation of lipids causes changes in fiber elasticity and initiates fibroplastic processes and collagen aging [2,15].…”

Citrus Essential Oils and Nanosystems towards Skin Delivery

“…Encapsulation of linalool improves its stability [48,57] and consequently increases its antioxidant activity since the terpene itself has radical-scavenging ability [58]. The higher radical-scavenging ability is important to ensure a more effective skin treatment as oxidative stress can worse dermatological diseases [59,60].…”