2019
DOI: 10.1155/2019/3085756
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Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases

Abstract: Oxidative stress is a consequence of the use of oxygen in aerobic respiration by living organisms and is denoted as a persistent condition of an imbalance between the generation of reactive oxygen species (ROS) and the ability of the endogenous antioxidant system (AOS) to detoxify them. The oxidative stress theory has been confirmed in many animal studies, which demonstrated that the maintenance of cellular homeostasis and biomolecular stability and integrity is crucial for cellular longevity and successful ag… Show more

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Cited by 355 publications
(251 citation statements)
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“…In particular, elevated levels of intracellular AGEs lead to protein cross-linking and aggregation resulting in an alteration in cell signaling, which causes cell damage and death. These alterations are implicated in diabetes and various chronic pathologies [6,20,21].…”
Section: Introductionmentioning
confidence: 99%
“…In particular, elevated levels of intracellular AGEs lead to protein cross-linking and aggregation resulting in an alteration in cell signaling, which causes cell damage and death. These alterations are implicated in diabetes and various chronic pathologies [6,20,21].…”
Section: Introductionmentioning
confidence: 99%
“…Individuals with higher body fat have higher caloric and dietary AGE consumption, mainly due to the adoption of a western dietary pattern, rich in simple sugars, saturated fats, and preference for highly processed foods . Moreover, overeating can also promote oxidative stress and as a result increase endogenous AGE formation . Therefore, weight management interventions, such as energy‐restricted diets and bariatric surgery, could play a role in decreasing serum AGE concentrations, both by reducing intake and endogenous formation .…”
Section: Introductionmentioning
confidence: 99%
“…Oxidative stress (OS) is a consequence of the use of oxygen in aerobic respiration by living organisms and is characterized as a persistent condition of an imbalance between the generation of ROS and the ability of the endogenous antioxidant system (AOS) to detoxify ROS [4]. The imbalance between pro-oxidants and antioxidants, which may result from diminished levels of antioxidants (AOX) or increased production of ROS [5], leads to tissue damage, lipids, membranes, proteins, and nucleic acids [6].…”
Section: Introductionmentioning
confidence: 99%
“…The main factors associated with an increase in oxidative stress in menopausal women include obesity, aging, decreased estrogen production, and diet [4,[7][8][9]. Chronic inflammation is a hallmark of aging and obesity and has been implicated in the release of ROS from different sources, including activated macrophages and neutrophils involved in inflammation that generates oxidants, such as peroxynitrite and nitrosoperoxycarbonate, hypohalous acids, and nitrosating agent [7].…”
Section: Introductionmentioning
confidence: 99%
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