Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia

Abstract

Objectives: We undertook the present study to investigate the possible alteration of oxidant/antioxidant status in the circulation of patients with prostate cancer and benign prostatic hyperplasia.Design and methods: Thiobarbituric acid reactive substances (TBARS), the enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and copper (Cu) and zinc (Zn) levels were estimated in the erythrocytes of 25 non-metastatic prostate cancer patients, 36 benign prostatic hyperplasia (BPH) patients and 24 age-and sex-matched healthy subjects (controls).Results: TBARS concentrations were significantly increased, while erythrocyte GPX and SOD activities were significantly decreased in the prostate cancer group versus controls (P b 0.001) and BPH group (P b 0.05). Zn levels were lowered in prostate cancer patients versus controls (P b 0.01) with no significant changes between BPH and cancer groups. Similarly, lipid peroxidation was increased (P b 0.05) with decreased SOD activity and Zn level (P b 0.05) in BPH versus controls.Conclusion: These results reveal an alteration in the lipid peroxidation index, with concomitant changes in the antioxidant defense system in prostate cancer patients compared to BPH patients. We hypothesize that an altered prooxidant-antioxidant balance may lead to an increase in oxidative damage and consequently may play an important role in prostate carcinogenesis.

Nuclear translocation of haeme oxygenase-1 is associated to prostate cancer

“…Haeme oxygenase-1 may therefore be one guardian of the genome, limiting mutations of DNA and promoting deletion of aberrant cells (Oates and West, 2006). An altered prooxidant/antioxidant balance in PCa patients, reflected by elevated lipid peroxidation and concomitant antioxidant depletion, was suggested to lead to an increase in oxidative damage playing an important role in prostate carcinogenesis (Yilmaz et al, 2004;Aydin et al, 2006).…”

Effects of Melandrium firmum methanolic extract on testosterone-induced benign prostatic hyperplasia in Wistar rats

“…In BPH, increased lipid peroxidation and decreased levels of antioxidants have been observed. [23][24][25] Various herbal extracts reduce oxidative stress in testosterone-induced BPH rats. [26][27][28][29] In addition, saw palmetto extract, which is commonly used to treat BPH, has shown antioxidant effects.…”

Oxidative stress parameters in patients with prostate cancer, benign prostatic hyperplasia and asymptomatic inflammatory prostatitis: A prospective controlled study

“…11 Aydin et al conducted a controlled study to evaluate antioxidant activity in the patients with PCa and BPH and revealed that PCa patients had decreased CuZn-SOD enzyme levels when compared with BPH and control. 21 Jun-Fu Zhou et al also demonstrated significantly decreased CuZn-SOD levels in chronic bacterial prostatitis (category 3), but the literature data regarding AIP patients is lacking. 22 In our study, decreased CuZn-SOD enzyme levels were found to be lower in PCa and BPH patients, but these differences were statistically significant only for BPH and control group patients.…”

“…Some authors demonstrated decreased activity while others showed no difference or increased activity. 21,[23][24][25] In their study, Biri et al reported increased CAT and GPx activity in PCa patients when compared with BPH and control. 25 They concluded that this increase was due to a rebound effect to increased oxidative stress in order to neutralize it.…”