Oxidative stress and antioxidant status in cervical cancer patients

Naidu, M. Smita K.; Suryakar, Adinath N.; Swami, Sanjay; Katkam, R. V.; Kumbar, K. M.

doi:10.1007/bf02913333

Cited by 89 publications

(86 citation statements)

References 9 publications

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“…On the contrary, a decrease of SOD activity was detected in blood cells of patients with cervical cancer. The decrease of SOD activity observed could be related to the generation of free radicals that cause direct damage to the enzyme by reticulation or mutation induction (Manoharan et al, 2004;Naidu et al, 2007). Besides, this decrease may be caused by an alteration of the oligoelements (essential trace elements) that act as cofactors of this enzyme, which may be considered as a risk factor of tumor growth or carcinogenesis (Naidu et al, 2007).…”

Section: Ros Adaptation By Cancer Cellsmentioning

confidence: 99%

“…The decrease of SOD activity observed could be related to the generation of free radicals that cause direct damage to the enzyme by reticulation or mutation induction (Manoharan et al, 2004;Naidu et al, 2007). Besides, this decrease may be caused by an alteration of the oligoelements (essential trace elements) that act as cofactors of this enzyme, which may be considered as a risk factor of tumor growth or carcinogenesis (Naidu et al, 2007). On the other hand, it was observed that the increase in the intensity of oxidative stress in the blood of patients with ovarian cancer is accompained by a decrease of antioxidants like SOD, catalase, vitamin C and vitamin E (Senthil et al, 2004).…”

Section: Ros Adaptation By Cancer Cellsmentioning

confidence: 99%

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Oxidative Therapy Against Cancer

Miguel¹,

Cordero²

2012

Oxidative Stress and Diseases

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Section: Ros Adaptation By Cancer Cellsmentioning

confidence: 99%

Section: Ros Adaptation By Cancer Cellsmentioning

confidence: 99%

Oxidative Therapy Against Cancer

Miguel¹,

Cordero²

2012

Oxidative Stress and Diseases

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“…24 Advanced cancer patients have deficiency of essential micronutrients like zinc, selenium, vitamin C and vitamin E, which support body's immune response. [25][26][27][28] …”

Section: Consequences Of Malnutritionmentioning

confidence: 99%

Palliative Nutritional Care for Cancer Patients

Kapoor¹,

Garg²,

Tewfik³

2016

Palliat Med Hosp Care Open J

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“…This protects the cell membrane from damage by ROS. But the decreased SOD levels may lead to increased lipid peroxidation resulting in the cellular rigidity and deformability [6]. This phenomena, i.e.…”

Section: Introductionmentioning

confidence: 99%

N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as a new potent for tumor imaging and therapy

A.¹,

T.²,

A.³

et al. 2012

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The development of new and effective antitumor agents is one of the main goals of medicinal and biochemical research at present. The present study is concerned with the evaluation of the previously synthesized N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as an antitumor agent against Ehrlich ascites carcinoma (EAC). The first part of the study (tumor imaging) was to investigate the biodistribution of NBPQD in the organs of EAC-bearing mice using iodine-125 isotope stressing on its distribution in the main organs (stomach, liver, spleen, kidney) in addition to blood and ascetic fluid. The second part was the assessment of the antitumor activity of NBPQD by estimating the tumor volume and the contents of total protein, total lipid, DNA and RNA in liver tissues. In addition, liver function tests and the redox status were assessed. Tumor volume and DNA, RNA, urea and malondialdehyde (MDA) levels and the liver enzymes activity were highly significantly increased (P < 0.001) in untreated EAC-bearing mice compared to control. However, total lipid and total protein in liver tissues in addition to serum albumin, glucose, reduced glutathione (GSH) as well as activities of glutathione reductase (GSH-R) and superoxide dismutase (SOD) all were highly significantly decreased in untreated EAC-bearing mice compared to controls. All these decreased parameters were highly significantly restored to their normal levels in NBPQD treated mice compared to the untreated EAC-bearing mice. The survival time of the NBPQD treated mice was longer than that of the untreated ones. It is thus, evident that NBPQD had a remarkable antitumor activity against EAC in Swiss albino mice.

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Oxidative stress and antioxidant status in cervical cancer patients

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Cited by 89 publications

References 9 publications

Oxidative Therapy Against Cancer

Oxidative Therapy Against Cancer

Palliative Nutritional Care for Cancer Patients

N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as a new potent for tumor imaging and therapy

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