Oxidative Stress and Antioxidant Status in Neonates Born to Pre-eclamptic Mother

Howlader, M Zakir Hossain; Parveen, Sayma; Tamanna, Sonia; Khan, Tanzir Ahmed; Begum, Firoza

doi:10.1093/tropej/fmp025

Cited by 44 publications

(36 citation statements)

References 20 publications

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“…Oxidative stress has been suggested to influence histone acetylation and phosphorylation [143], telomere length [144] and vascular gene expression. Some oxidative stress is required for normal fetal development [145], but the ischaemic pre-eclamptic placenta has significantly decreased total antioxidant capacity compared with the normal placenta, and there is a correlation between levels of oxidative stress in maternal peripheral blood and cord blood in normotensive and pre-eclamptic pregnancies [146,147], with levels significantly higher in pre-eclampsia [127,147]. The levels of oxidative stress induced by pre-eclampsia itself are sufficient to cause damage to the fetus, as placental tissue samples have higher levels of oxidative DNA damage in pre-eclamptic pregnancies, whether or not there has been fetal growth restriction [148].…”

Section: Mechanism Of Long-term Programing? the Cardiovascular Systemmentioning

confidence: 99%

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

et al. 2012

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Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy. Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased risk of later cardiovascular disease. Intriguingly, the offspring of affected pregnancies also have an increased risk of higher blood pressure and almost double the risk of stroke in later life. Experimental approaches to identify the key features of pre-eclampsia responsible for this programming of offspring cardiovascular health, or the key biological pathways modified in the offspring, have the potential to highlight novel targets for early primary prevention strategies. As pre-eclampsia occurs in 2–5% of all pregnancies, the findings are relevant to the current healthcare of up to 3 million people in the U.K. and 15 million people in the U.S.A. In the present paper, we review the current literature that concerns potential mechanisms for adverse cardiovascular programming in offspring exposed to pre-eclampsia, considering two major areas of investigation: first, experimental models that mimic features of the in utero environment characteristic of pre-eclampsia, and secondly, how, in humans, offspring cardiovascular phenotype is altered after exposure to pre-eclampsia. We compare and contrast the findings from these two bodies of work to develop insights into the likely key pathways of relevance. The present review and analysis highlights the pivotal role of long-term changes in vascular function and identifies areas of growing interest, specifically, response to hypoxia, immune modification, epigenetics and the anti-angiogenic in utero milieu.

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Section: Mechanism Of Long-term Programing? the Cardiovascular Systemmentioning

confidence: 99%

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

et al. 2012

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“…This is an indication of oxidative stress in preeclampsia/eclampsia. Signifi cant elevation of protein carbonyl level in maternal circulation [ 66 , 67 ] and cord blood [ 60 ] of preeclamptic mothers has been reported. The previous study showed higher plasma protein carbonyl levels that are markers of oxidative protein damage in preeclamptic pregnant women than those in healthy pregnant women [ 68 ].…”

Section: Oxidative Damage Markersmentioning

confidence: 99%

Oxidative Stress in Low Birth Weight Newborns

Negi

Pande

Karki

et al. 2014

Free Radicals in Human Health and Disease

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Free radical damage has been recognized to be a common pathogenic mechanism of many neonatal diseases. An excessive and/or sustained increase in free radical production associated with diminished effi cacy of the antioxidant defense systems results in oxidative stress, which occurs in many pathologic processes and contributes signifi cantly to disease and can be the key link between size at birth and increased morbidity later in life. Low birth weight is closely associated with fetal and neonatal mortality and morbidity, inhibited growth and cognitive development, and chronic diseases later in life. Low birth weight is considered the primary factor associated with a poor perinatal outcome of maternal preeclampsia/ eclampsia and premature birth. High oxidative stress and low level of enzymatic antioxidants and antioxidant nutrients such as vitamins A, E, and C, zinc, copper, and selenium and antioxidant status might be increasing the risk of pathogenesis of major complications in low birth weight newborns.

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“…Cumulative evidence in recent years points towards biochemical imbalance in pre-eclampsia with an increase of oxidative stress and, at the same time, a deficient antioxidant protection. Significant elevation of malondiadehyde (MDA) levels in cord blood of pair matched pre-eclamptic mothers have been reported [21,22] whereas others have reported decline in its level [23] or no significant change [24,25] but Karabulut et al [26] inferred elevation of MDA levels in cord and mother during pre-eclamptic development compared to normal pregnancy. Similar contradictions exist about the level of antioxidant enzymes in the cord blood of pre-eclamptic mothers.…”

Section: Clinical Aspects Of Preeclampsiamentioning

confidence: 99%

Oxidative Stress and Preeclampsia

Negi¹,

Pande²,

Karki³

et al. 2012

ALS

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Eclampsia is one of the most common pregnancy complications causing high mortality and morbidity for both mother and foetus. Low birth weight and pre-maturity are very common features. Pre-eclampsia is associated with oxidative stress in the maternal circulation. The etiology and pathogenesis of the pregnancy syndrome preeclampsia remain poorly understood. There is substantial evidence to suggest that the diverse manifestations of preeclampsia, including altered vascular reactivity, vasospasm, and discrete pathology in many organ systems, are derived from pathologic changes within the maternal vascular endothelium. The imbalance between oxidative damage and antioxidant defences in pre-eclampsia leads to endothelial cell dysfunction. Endothelial cell dysfunction appears to be a central feature in the patho-physiology of pre-eclampsia.

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Oxidative Stress and Antioxidant Status in Neonates Born to Pre-eclamptic Mother

Cited by 44 publications

References 20 publications

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Pre-eclampsia and offspring cardiovascular health: mechanistic insights from experimental studies

Oxidative Stress in Low Birth Weight Newborns

Oxidative Stress and Preeclampsia

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