Oxidative Stress and Antioxidant Status in Vitiligo Patients

Abstract

ABSTRACT:Vitiligo is a common pigmentary disorder characterized by depigmented patches or macules caused by the destruction of melanocytes. The pathogenetic mechanisms involved in vitiligo have not been completely clarified. Oxidative stress and reduced circulating antioxidants could be important phenomena in the pathophysiology of vitiligo. We measured serum malondialdehyde (MDA) as an indicator of oxidative stress and serum zinc and vitamin C to check antioxidant status in thirty Vitiligo patients. Thirty healthy control subjects were also recruited by matching the socio-demographic status to that of the patients. Blood samples were analyzed for determining the serum levels of Zn (by atomic absorption spectroscopy), Vitamin C and MDA (by UV-VIS spectroscopy). Serum level of MDA increased in vitiligo patients significantly (p < 0.05) in the present study, where as serum level of Zn increased and serum Vit-C decreased in patients compared to control but the changes were not statistically significant (p > 0.05). Our study reveals the presence of an imbalance in the oxidant/antioxidant system in vitiligo patients which supports a free radical-mediated damage in the pathogenesis of vitiligo.

Critical appraisal of the oxidative stress pathway in vitiligo: a systematic review and meta‐analysis

“…Markers of lipid peroxidation are therefore considered as good measures of oxidative stress . Seventeen different studies including 745 patients clearly demonstrate increased MDA concentrations in patients with vitiligo . Five additional studies (2119 patients) confirmed increased lipid peroxidation in erythrocytes of patients with vitiligo …”

“…14 Seventeen different studies including 745 patients clearly demonstrate increased MDA concentrations in patients with vitiligo. 7,[11][12][13][15][16][17][18][19][20][21][22][23][24][25][26][27] Five additional studies (2119 patients) confirmed increased lipid peroxidation in erythrocytes of patients with vitiligo. 13,[28][29][30][31] Hydrogen peroxide (H 2 O 2 ) and ROS.…”

Serum Copper and Zinc Levels in Vitiligo Patients

“…Zn and Cu are involved in many homeostatic mechanisms of the body, such as specific immunity, inflammation and oxidative stress (OS) (10) . Decreased serum Zn and Cu levels have been reported in vitiligo by some investigators (11) , while others contradicted these findings (11) . Aim of study: this study aimed to detect the possible changes in the metabolism of serum Zn and Cu levels in vitiligo patients and their relation to the etiopathogenesis of vitiligo.…”

Comparison between thermal analysis and mass spectroscopic studies of uranyl oxinates

“…A number of physicochemical methods of analysis were used, such as thermal analysis [1][2][3], X-ray analysis [4] and different spectroscopic techniques [7][8][9][10]. The mode of chelation in these compounds has been discussed [ 1,2]. Spectrophotometric determination of uranium in its ores on the basis of these studies has also been performed [7,8].…”

“…oxines and other phenolic compounds, have been reported previously [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. A number of physicochemical methods of analysis were used, such as thermal analysis [1][2][3], X-ray analysis [4] and different spectroscopic techniques [7][8][9][10].…”