2005
DOI: 10.1024/0300-9831.75.5.333
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Oxidative Stress and Antioxidant Status in Rat Blood, Liver and Muscle: Effect of Dietary Lipid, Carnitine and Exercise

Abstract: The purpose of this study was to determine the effect of dietary fat, carnitine supplementation, and exercise on oxidative damage and antioxidant status. Male Wistar rats (60 days old) were fed diets containing either hydrogenated fat (HF) or peanut oil (PO) with or without 0.5 mg % (of dry diet) carnitine. The rats were given exercise, i.e. swimming for 60 minutes, for 6 days/week for 6 months under each dietary condition. The blood malondialdehyde (MDA) level was higher in PO-fed rats, more so in exercising … Show more

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Cited by 29 publications
(27 citation statements)
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“…The present study, in parallel with other studies, suggests that LC plays a role against oxidative damage, preventing lipid peroxidation and supporting the antioxidant system (24). Other research has shown that LC reduces acetaminophen-induced high aspartate transaminase, alanine transaminase, total sialic acid, and MDA concentrations (25).…”
Section: Discussionsupporting
confidence: 76%
“…The present study, in parallel with other studies, suggests that LC plays a role against oxidative damage, preventing lipid peroxidation and supporting the antioxidant system (24). Other research has shown that LC reduces acetaminophen-induced high aspartate transaminase, alanine transaminase, total sialic acid, and MDA concentrations (25).…”
Section: Discussionsupporting
confidence: 76%
“…The patients who were enduring high-ALT levels also showed increased weight, body mass index, waist circumference, hip circumference, body fat density, and insulin resistance (55). Another research group showed that fat intake impaired the benefits of physical exercise in reducing lipid peroxidation, and it blocked the release of hepatic glutathione production for the muscles and the blood (5). …”
Section: Discussionmentioning
confidence: 99%
“…Dietary fat seems to reduce the systemic antioxidant potential, as it blocks the hepatic production of glutathione (GSH) but induces the oxidation of fatty acids (5, 6). This increase in lipid peroxidation products promotes a chain of events that furthers the development of CVD altering the immune system activity (7–11).…”
Section: Introductionmentioning
confidence: 99%
“…На цей орган припадає велика частина клі-рингових процесів, отже надниркові залози також впливають на імунну систему [2]. Тому надниркові залози є оптимальним органом для вивчення різ-них ефектів, що реалізуються в звʼязку зі станом стресу і запальними процесами за типом гіпер-чутливості.…”
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