Oxidative stress and antioxidant status in patients with alcoholic liver disease

Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease

“…While the information on the pathogenesis of NAFLD is limited, that of ALD is supported by numerous studies pointing toward OS. [5,6]. The liver injury in ALD is dependent on the metabolic product of ethanol (acetaldehyde) causing functional and metabolic derangements [7] along with induction of cytochrome P450 2E1 (CYP450 2E1) that results in increased generation of reactive oxygen species (ROS) and development of OS [8].…”

Are we over estimating serum oxidative stress/lipid peroxidation in alcoholic liver diseases? A review

“…Most of the human studies done have estimated the oxidant, antioxidant levels in serum in alcoholic liver diseases but not correlated these parameters to the hepatic tissue level. [50][51][52][53] Bogdanska J et al, in their study found that there is statistically significant increase in erythrotic SOD (ESOD) in alcoholics than in non-alcoholics, also there was no significant difference in ESOD in alcoholics with and without palpable liver, which seemed to be not related to liver damage, [54] which indicated a role of other organs too. Circulating phospholipid hydroperoxides have been proposed as new markers of oxidative stress in alcoholic patients, Yang L et al, in their rat experiment data showed that measurement of oxidative stress does not directly correlate with the hepatic oxidative stress imposed by liver catabolism of ethanol.…”

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“…The consequential change in redox imbalance caused by ROS generation has been observed in patients with alcoholic liver disease [7] but attempts to ameliorate these disturbances through the administration of antioxidants has met with mixed results [1,8,9]. In contrast to this, many animal model studies (principally with rodents) have shown that these antioxidants and vitamin E in particular do have mitigating effects on free radical damage of the liver related to alcohol abuse [10][11][12][13][14].…”

“…Vitamin E has been extensively studied as a cardio-protectant for many years, but there is little agreement as to its effectiveness [9,[16][17][18][19]. In general, plasma antioxidants are low in patients with alcoholic liver disease [8] and with non-alcoholic fatty liver [20]. While clearly an antioxidant, vitamin E has shown mixed results in clinical trials on a variety of liver disease patients [21][22][23][24][25].…”