Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter

Montiel-Dávalos, Angélica; Ibarra-Sánchez, Marı́a de Jesús; Ventura-Gallegos, José Luis; Alfaro-Moreno, Ernesto; López‐Marure, Rebeca

doi:10.1016/j.tiv.2009.08.004

Cited by 84 publications

(53 citation statements)

References 51 publications

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“…The correlation suggested that the levels of TNF-α was influenced by the indoor level of PM 2.5 , PM 10 and the urban air particles stimulated TNF-α production (Montiel-Dávalos et al, 2010). Findings from this study generally corresponded with other studies, which provide evidence for particulate matters and the occurrence of TNF-α.…”

Section: Concentration Of Tnf-α Level and Indoorsupporting

confidence: 87%

Tumor Necrosis Factor-Alpha as Biomarkers of Exposure to Indoor Pollutants Among Primary School Children in Klang Valley

Jalaludin

Noh

Suhaimi

et al. 2014

American Journal of Applied Sciences

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Poor indoor air quality can be particularly harmful to children and interfere with the growth of their lung function as they spend much of their time indoors. In order to understand the mechanism of exposure in the airways, biomarkers were used as a surrogate for biological responses towards indoor air pollutants. This study aims to investigate the association between indoor air pollutants (PM 2.5 , PM 10 and NO 2 ) among school children in different area of urban and rural site in Klang Valley. A cross sectional comparative study was conducted among 430 healthy schoolchildren from a national primary school. Methods involved questionnaires based on American Thoracic Society and sputum samples for biomarkers assay. Indoor exposure to PM 2.5 and PM 10 (Dust Trak Aerosol Monitor) and NO 2 (LaMotte Air Sampler) were measured in the classroom. Mean concentration of PM 2.5 (50.72 µg/m 3 ) in urban schools were significantly higher compared to rural (28.36 µg/m 3 ) school. Similar trend found in indoor level of PM 10 in urban and rural schools with 87.04 µg/m 3 and 56.76 µg/m 3 respectively. The mean exposure level of NO 2 of urban schools (0.12 ppm) is nearly 4 times higher than the level in rural areas (0.032 ppm). A significant association was found between indoor air concentrations (PM 2.5 and PM 10 ) with TNF-alpha level. Children from rural areas are exposed to less air pollutants compared to those from urban area and this study also suggests that higher exposure to PM 2.5 , PM 10 and NO 2 are associated with increasing of TNF-alpha level.

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Section: Concentration Of Tnf-α Level and Indoorsupporting

confidence: 87%

Tumor Necrosis Factor-Alpha as Biomarkers of Exposure to Indoor Pollutants Among Primary School Children in Klang Valley

Jalaludin

Noh

Suhaimi

et al. 2014

American Journal of Applied Sciences

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“…An increase in morbidity and mortality was associated with the exposure to urban PM 10 obtained in three zones of the MCMA (North, Center and South), which were cytotoxic, genotoxic and proinflammatory , 2007García-Cuellar et al, 2002;Osornio-Vargas et al, 2003;). Montiel-Dávalos et al (2010) showed that oxidative stress and apoptosis (programmed cellular death) are induced in human endothelial cells exposed to MC particulate matter. PM 10 induced impairment of the antioxidant defense systems, without changes in cell viability (Chirino et al, 2010).…”

Section: Toxic Effects and Human Health Riskmentioning

confidence: 99%

Organic Compound in Airborne Particles and their Genottoxic Effects in Mexico City

Villalobos-Pietrini¹,

Amador-Muñóz²,

Valle-Hernández³

et al. 2011

Air Quality Monitoring, Assessment and Management

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“…KB was involved in the design of the study, oxidative reactivity assays and revisions of the particles, d) spherical particle with nodular surface and C-signature suggesting a biogenic 5 particle, e) aged NaCl particle, and f) mineral 6 particle. size, (b) change in particle mass and particle number in the different particle size fractions.…”

mentioning

confidence: 99%

Resolution of the mediators of in vitro oxidative reactivity in size-segregated fractions that may be masked in the urban PM10 cocktail

Price

Jones

Bérubé

2014

Science of The Total Environment

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Highlights 1 The oxidative reactivity (OR) of size segregated PM was tested at a traffic site 2  Ultrafine and fine PM size fractions caused more DNA damage than coarse PM 3  PM exhibited more OR in comparison to manufactured carbon black particles 4  Zn (and Fe) were implicated in the generation of reactive oxygen species in PM 5  Size, surface area and metals were important particle characteristics for OR oxidative reactivity (OR). PM10 was collected in 11 size fractions at a traffic site in Swansea, 7 UK, using an Electrical Low Pressure Impactor (ELPI). The PM physicochemical properties 8 (including size, morphology, type, and transition metals) were tested. The plasmid scission 9 assay (PSA) was used for OR testing of all particles. The ultrafine and fine PM (N28-2399; 28 -10 2399 nm) caused more DNA damage than coarse PM (N2400-10,000), and the increased capacity study PM-derived DNA damage was dependent upon; 1) particle size, 2) surface area, and 2) 19 transition metals. This study supports the view that ROS formation by PM10 is related to 20 physicochemistry using evidence with an increased particle size resolution.

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Oxidative stress and apoptosis are induced in human endothelial cells exposed to urban particulate matter

Cited by 84 publications

References 51 publications

Tumor Necrosis Factor-Alpha as Biomarkers of Exposure to Indoor Pollutants Among Primary School Children in Klang Valley

Tumor Necrosis Factor-Alpha as Biomarkers of Exposure to Indoor Pollutants Among Primary School Children in Klang Valley

Organic Compound in Airborne Particles and their Genottoxic Effects in Mexico City

Resolution of the mediators of in vitro oxidative reactivity in size-segregated fractions that may be masked in the urban PM10 cocktail

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