Oxidative stress and cancer: An overview

Sosa, Venus; Moliné, Teresa; Somoza, Rosa; Paciucci, Rosanna; Kondoh, Hiroshi; Lleonart, Matilde E.

doi:10.1016/j.arr.2012.10.004

Cited by 1,233 publications

(899 citation statements)

References 166 publications

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“…The most important antioxidant and major cause of oxidative damage to the body's bimolecules is ROS. ROS also plays an important role in the formation of reactive species such as RNS (Yoshikawa and Naito, 2002;Gonenc et al, 2005;2006;Sosa et al, 2013).…”

Section: Free Radicals (Oxidants)mentioning

confidence: 99%

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Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

152

108

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Oxidative stress is caused by an imbalance in the redox status of the body. In such a state, increase of free radicals in the body can lead to tissue damage. One of the most important species of free radicals is reactive oxygen species (ROS) produced by various metabolic pathways, including aerobic metabolism in the mitochondrial respiratory chain. It plays a critical role in the initiation and progression of various types of cancers. ROS affects different signaling pathways, including growth factors and mitogenic pathways, and controls many cellular processes, including cell proliferation, and thus stimulates the uncontrolled growth of cells which encourages the development of tumors and begins the process of carcinogenesis. Increased oxidative stress caused by reactive species can reduce the body's antioxidant defense against angiogenesis and metastasis in cancer cells. These processes are main factors in the development of cancer. Bimolecular reactions cause free radicals in which create such compounds as malondialdehyde (MDA) and hydroxyguanosine. These substances can be used as indicators of cancer. In this review, free radicals as oxidizing agents, antioxidants as the immune system, and the role of oxidative stress in cancer, particularly breast cancer, have been investigated in the hope that better identification of the factors involved in the occurrence and spread of cancer will improve the identification of treatment goals.

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Section: Free Radicals (Oxidants)mentioning

confidence: 99%

“…Products derived from this injury are used as biomarkers of oxidative stress in the assessment and diagnosis of all cancers. Especially breast cancer (Gonenc et al, 2005;Dayem et al, 2010;Sosa et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Nourazarian¹,

Kangari²,

Salmaninejad³

2014

Asian Pacific Journal of Cancer Prevention

152

108

View full text Add to dashboard Cite

show abstract

“…Compared to normal cells, tumorigenic cells can endure high levels of ROS by inducing new redox balances within their metabolisms. In this way, cancer cells have the capacity to survive against free radical damage through reprogramming their metabolic rate and increasing proliferation (Sosa et al, 2013). Mitochondria have a great impact on tumor cell survival by mediating apoptotic pathways (Gogvadze et al, 2008); the maintenance of mitochondrial potential and oxidative equilibrium controls the cell viability.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, enhanced generation and accumulation of ROS is lethal for cells through cellular mechanisms. This includes oxidative damage to cellular components, which in turn affects cellular proliferation, apoptosis, tissue invasion, and metastasis (Sosa et al, 2013). Compared to normal cells, tumorigenic cells can endure high levels of ROS by inducing new redox balances within their metabolisms.…”

Section: Introductionmentioning

confidence: 99%

“…The increased glucose uptake related to the Warburg effect not only serves as a source of ATP generation through the tricarboxylic acid (TCA) cycle, but also as a source of carbon and metabolites harnessed in the synthesis of macromolecules supporting cellular proliferation (Huang et al, 2014). This is predominantly seen in fast-growing tumor cells (Jose et al, 2011) such as hepatoma, providing a growth advantage over healthy cells as they become less exposed to oxidative stress by avoiding high levels of reactive oxygen species (ROS) (Kondoh et al, 2007;Sosa et al, 2013). Hepatocellular carcinoma (HCC) is a type of liver cancer, which primarily results from viral hepatitis B infection.…”

Section: Introductionmentioning

confidence: 99%

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Sodium borate treatment induces metabolic reprogramming in hepatocellular carcinoma through SIRT3 activation

Ustuner¹,

Çimen²

2016

Turk J Biol

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Sirtuins are NAD + -dependent deacetylases and ADP ribosyltransferases that are activated under stress conditions such as calorie restriction and starvation. Boron, which is mostly found in the form of boric acid (BA) or sodium borate (NaB), is known to bind NAD + . In this study, the effect of NaB on hepatoma cell line HEP3B was investigated by analyzing the proteins harvested from NaB-treated and serum-starved HEP3B cells. The NaB treatment (15 µg/mL) led to a decrease in the overall proteome acetylation and particularly in mitochondria, the synthesis rate of respiratory complexes, the amount of cellular reactive oxygen species, and the proliferation rate of HEP3B cells. On the other hand, the cellular ratio of NAD + /NADH and the deacetylase activity of mitochondrial sirtuin, SIRT3, were found to be elevated. The results of this study suggest a link between boron treatment and activation of SIRT3 by means of a NAD + -NaB interaction, which reprograms cellular metabolism. This study is expected to pave the way for new findings uncovering the metabolic changes in HEP3B cells related to SIRT3 activity upon NaB treatment.

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Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality

Liu,

Lehmler,

et al. 2024

JAMA Netw Open

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ImportancePolybrominated diphenyl ethers (PBDEs) are an important group of persistent organic pollutants with endocrine-disrupting properties. However, prospective cohort studies regarding the association of PBDE exposure with long-term health outcomes, particularly mortality, are lacking.ObjectiveTo examine the association of environmental exposure to PBDEs with risk of all-cause and cause-specific mortality.Design, Setting, and ParticipantsThis nationally representative cohort study used data from the National Health and Nutrition Examination Survey 2003 to 2004 and linked mortality information through December 31, 2019. Adults aged 20 years or older with available data on PBDE measurements and mortality were included. Statistical analysis was performed from February 2022 to April 2023.ExposuresPBDE analytes in serum samples were measured using solid phase extraction and isotope dilution gas chromatography high-resolution mass spectrometry.Main Outcomes and MeasuresAll-cause mortality, cancer mortality, and cardiovascular mortality.ResultsThis study included 1100 participants (mean [SE] age, 42.9 [0.6] years; proportion [SE] female, 51.8% [1.6%]; proportion [SE] Hispanic, 12.9% [2.7%]; proportion [SE] non-Hispanic Black, 10.5% [1.6%]; proportion [SE] non-Hispanic White, 70.8% [3.7%]; proportion [SE] other race and ethnicity, 5.8% [1.1%]). During 16 162 person-years of follow-up (median [IQR] follow-up, 15.8 [15.2-16.3] years; maximum follow-up, 17 years), 199 deaths occurred. Participants with higher serum PBDE levels were at higher risk for death. After adjustment for age, sex, and race and ethnicity, lifestyle and socioeconomic factors, and body mass index, participants with the highest tertile of serum PBDE levels had an approximately 300% increased risk of cancer mortality (HR, 4.09 [95% CI, 1.71-9.79]) compared with those with the lowest tertile of serum PBDE levels. No significant association of PBDE exposure with all-cause mortality (HR, 1.43 [95% CI, 0.98-2.07]) or cardiovascular mortality (HR, 0.92 [95% CI, 0.41-2.08]) was observed.Conclusions and RelevanceIn this nationally representative cohort study, PBDE exposure was significantly associated with an increased risk of cancer mortality. Further studies are needed to replicate the findings and determine the underlying mechanisms.

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Oxidative stress and cancer: An overview

Cited by 1,233 publications

References 166 publications

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

Sodium borate treatment induces metabolic reprogramming in hepatocellular carcinoma through SIRT3 activation

Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality

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