Oxidative stress and cellular pathologies in Parkinson’s disease

Puspita, Lesly; Chung, Sung Tae; Shim, Jae Kun

doi:10.1186/s13041-017-0340-9

Cited by 394 publications

(284 citation statements)

References 123 publications

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“…), which have been shown to exert antioxidant and antiinflammatory effects and thereby may conceivably protect from neurodegeneration. 36,[41][42][43][44] Concomitantly, these MeDi components and the whole MeDi pattern have been associated with favorable gut microbiota characteristics, [45][46][47] possibly ameliorating the gut-tobrain signaling and therefore beneficially affecting neuronal functioning in both the enteral and central nervous system. [38][39][40]48 Nevertheless, given that the association of MeDi with lower probability score of pPD in our study still remains when performing the analysis without constipation, this raises the possibility that association of MeDi with other pPD markers may be also pertinent.…”

Section: Discussionmentioning

confidence: 99%

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

et al. 2018

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Background The International Parkinson and Movement Disorder Society recently introduced a methodology for probability score calculation for prodromal PD. Objectives To assess the probability of prodromal PD in an older population and investigate its possible association with Mediterranean diet adherence. Methods Data from a population‐based cohort study of older adults (HEllenic Longitudinal Investigation of Aging and Diet) in Greece were used. Probability of prodromal PD was calculated according to International Parkinson and Movement Disorder Society research criteria. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate Mediterranean diet adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. Results Median probability of prodromal PD was 1.9%, ranging from 0.2 to 96.7% in 1,731 PD‐free individuals aged ≥ 65 (41% male). Lower probability for prodromal PD (P < 0.001) in the higher Mediterranean diet adherence groups was noted, driven mostly by nonmotor markers of prodromal PD, depression, constipation, urinary dysfunction, and daytime somnolence. Each unit increase in Mediterranean diet score was associated with a 2% decreased probability for prodromal PD (P < 0.001). Compared to participants in the lowest quartile of Mediterranean diet adherence, those in the highest quartile were associated with a ∼21% lower probability for prodromal PD. Conclusions Adherence to the Mediterranean diet is associated with lower probability of prodromal PD in older people. Further studies are needed to elucidate the potential causality of this association, potential relation of the Mediterranean diet to delayed onset or lower incidence of PD, as well as the underlying neurobiological mechanisms. © 2018 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

et al. 2018

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“…Salsolinol also disrupts clearance of dopamine by monoamine oxidases (Napolitano, Manini, & d'Ischia, ), shifting dopamine metabolism toward more damaging metabolic pathways which produce DAQs. Another derivative, 6‐hydroxydopamine (6‐OHDA), generates substantial amounts of O 2 − by inhibiting mitochondrial ETC complexes I and IV (Puspita et al, ). Given the enormous neurotoxic potential of DAQs, and the remarkably slow conversion of DAQs to neuromelanin (NM), it is likely endogenous mechanisms of DAQ detoxification exist.…”

Section: Dopamine and Iron Redox Chemistrymentioning

confidence: 99%

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

2019

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Parkinson's disease prevalence is rapidly increasing in an aging global population. With this increase comes exponentially rising social and economic costs, emphasizing the immediate need for effective disease‐modifying treatments. Motor dysfunction results from the loss of dopaminergic neurons in the substantia nigra pars compacta and depletion of dopamine in the nigrostriatal pathway. While a specific biochemical mechanism remains elusive, oxidative stress plays an undeniable role in a complex and progressive neurodegenerative cascade. This review will explore the molecular factors that contribute to the high steady‐state of oxidative stress in the healthy substantia nigra during aging, and how this chemical environment renders neurons susceptible to oxidative damage in Parkinson's disease. Contributing factors to oxidative stress during aging and as a pathogenic mechanism for Parkinson's disease will be discussed within the context of how and why therapeutic approaches targeting cellular redox activity in this disorder have, to date, yielded little therapeutic benefit. We present a contemporary perspective on the central biochemical contribution of redox imbalance to Parkinson's disease etiology and argue that improving our ability to accurately measure oxidative stress, dopaminergic neurotransmission and cell death pathways in vivo is crucial for both the development of new therapies and the identification of novel disease biomarkers.

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“…Various pathological mechanisms induced by MPTP administration, such as defects in mitochondrial respiration, oxidative stress, and inflammation cause dopaminergic depletion in the nigrostriatal pathway, which predominantly appears in PD patients [16,17]. Thus, assessing dopaminergic depletion is an important indicator for establishing a reliable MPTP mouse model of PD.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

et al. 2019

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MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is commonly used to induce nigrostriatal defects to induce parkinsonism and/or parkinsonian syndrome, to replicate the lesions seen in Parkinson's disease (PD), with use in numerous PD models in mice. It has been suggested that various biological characteristics including strain could result in differing mortality rates, sensitivity to MPTP administration, and reproducibility of lesions in mice, but there is no evidence on the sensitivity of C57BL/6 mice from different origins to MPTP and its associated pathological lesions. In this study, we investigated the magnitude of the dose-dependent response to acute MPTP administration in C57BL/ 6NKorl mice and two commercialized C57BL/6 stocks derived from the United States and Japan. We measured biological features (body weight, temperature, and composition), nigrostriatal neurotoxic responses (dopamine levels, tyrosine hydroxylase enzymes, and protein carbonylation) and motor function. In results, the three different C57BL/6 stocks exhibited similar overall neurotoxic response and locomotor impairment which increased in a dose-dependent manner with acute MPTP administration (10 mg/kg, 20 mg/kg, and 30 mg/kg, all with external heat support), although some of these differences were not significant. In conclusion, this study provides scientific evidence that C57BL/6NKorl mice can be used as an alternative animal model for practical and targeted PD research.

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Oxidative stress and cellular pathologies in Parkinson’s disease

Cited by 394 publications

References 123 publications

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

Mediterranean diet adherence is related to reduced probability of prodromal Parkinson's disease

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources

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