Oxidative stress and decreased dopamine levels induced by imidacloprid exposure cause behavioral changes in a neurodevelopmental disorder model in Drosophila melanogaster

Janner, Dieniffer Espinosa; Gomes, Nathalie Savedra; Poetini, Márcia Rósula; Poleto, Ketnne Hanna; Musachio, Elize Aparecida Santos; Almeida, Francielli Polet de; Amador, Elen Caroline de Matos; Reginaldo, Jocemara Corrêa; Ramborger, Bruna Piaia; Roehrs, Rafael; Prigol, Marina; Guerra, Gustavo Petri

doi:10.1016/j.neuro.2021.05.006

Cited by 23 publications

(11 citation statements)

References 72 publications

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“…In insects, dopamine is mainly present in all parts of the nervous system [48] where it has neuromodulatory functions. Application of the neonicotinoid insecticide imidacloprid to Drosophila melanogaster results in decreased dopamine levels in the brain [49]. Nevertheless, no significant changes in dopamine levels were recorded in the cockroach brain after bee venom application in this study (see Figure 9).…”

Section: Effect Of Venom/akh On Physiological Processescontrasting

confidence: 53%

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Bodláková

Černý

Štěrbová

et al. 2021

Toxins

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Bees originally developed their stinging apparatus and venom against members of their own species from other hives or against predatory insects. Nevertheless, the biological and biochemical response of arthropods to bee venom is not well studied. Thus, in this study, the physiological responses of a model insect species (American cockroach, Periplaneta americana) to honeybee venom were investigated. Bee venom toxins elicited severe stress (LD50 = 1.063 uL venom) resulting in a significant increase in adipokinetic hormones (AKHs) in the cockroach central nervous system and haemolymph. Venom treatment induced a large destruction of muscle cell ultrastructure, especially myofibrils and sarcomeres. Interestingly, co-application of venom with cockroach Peram-CAH-II AKH eliminated this effect. Envenomation modulated the levels of carbohydrates, lipids, and proteins in the haemolymph and the activity of digestive amylases, lipases, and proteases in the midgut. Bee venom significantly reduced vitellogenin levels in females. Dopamine and glutathione (GSH and GSSG) insignificantly increased after venom treatment. However, dopamine levels significantly increased after Peram-CAH-II application and after co-application with bee venom, while GSH and GSSG levels immediately increased after co-application. The results suggest a general reaction of the cockroach body to bee venom and at least a partial involvement of AKHs.

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Section: Effect Of Venom/akh On Physiological Processescontrasting

confidence: 53%

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Bodláková

Černý

Štěrbová

et al. 2021

Toxins

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“…Overall, the observed histological profiles in the fat body cells and midgut tissue included the different shapes of cells and the level of cytoplasmic homogeneity. These changes may be caused by excess ROS in the organisms as organisms can produce excessive ROS under the stimulation of imidacloprid ( Janner et al, 2021 ). The increased levels of ROS lead to oxidative stress, gastrointestinal damage ( Xiao et al, 2006 ), lipid peroxidation, and cell damage ( Davalli et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the AChE activity, antioxidant enzyme activities, and MDA contents were considered as the significant biomarkers to investigate the influence of pollutants ( Deng et al, 2021 ; Guo et al, 2022 ). Under the stress of imidacloprid, the acetylcholinesterase in the synapse cannot metabolize imidacloprid in the postsynaptic nAChRs, and this caused continuous nerve impulses and induced oxidative stress ( Jepson et al, 2006 ; Janner et al, 2021 ). Reactive oxygen species (ROS) can be produced in living organisms, but excessive ROS can also result in oxidative stress and lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Physiological Responses of the Firefly Pyrocoelia analis (Coleoptera: Lampyridae) to an Environmental Residue From Chemical Pesticide Imidacloprid

Wang

Cao²,

Wang³

2022

Front. Physiol.

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Imidacloprid, a neonicotinoid insecticide, is widely applied to control insect pests across a broad spectrum. Though the impact of residues from this chemical pesticide on non-target organisms in the field has been reported, it was not well characterized across a wide range of ecosystems, especially for some species considered as environmental indicators that live in forests. The effects of sublethal dose of imidacloprid on firefly, Pyrocoelia analis, were analyzed physiologically and biochemically in this study to better understand the impact of chemical pesticide application on environmental indicators such as fireflies. After imidacloprid treatment, the midgut tissues of the larva presented an abnormal morphology featured as atrophy of fat body cells, shrinking cells, and the destruction of a midgut structure. The activities of antioxidant enzymes, superoxide dismutase, catalase, and peroxidase were noticeably increased during early exposure to sublethal imidacloprid and then decreased at later stages. The malondialdehyde content significantly increased after 12 h of exposure to imidacloprid compared with the control. Similarly, the enzyme activities of polyphenol oxidase and acetylcholinesterase were increased after the imidacloprid treatment and then decreased at the later stage. In summary, a sublethal dose of imidacloprid caused destructive change in the tissue structure, and this damage was followed by an excessive reactive oxygen species that could not be eliminated by antioxidant enzymes. Our results indicated that the residues of imidacloprid might cause severe toxicity to non-target insects in the environment even far away from the agro-ecosystem where the chemicals were applied.

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“…Most of all, they act selectively on the insect central nervous system [1] . However, several studies have shown that the use of neonicotinoid insecticides, such as imidacloprid, is a key factor for declining biodiversity of non‐target terrestrial insects [2–5] . In addition, imidacloprid residues affect soil properties, [6] soil organisms, [7–9] and take a threat to human health [10] .…”

Section: Introductionmentioning

confidence: 99%

“…[1] However, several studies have shown that the use of neonicotinoid insecticides, such as imidacloprid, is a key factor for declining biodiversity of nontarget terrestrial insects. [2][3][4][5] In addition, imidacloprid residues affect soil properties, [6] soil organisms, [7][8][9] and take a threat to human health. [10] Imidacloprid is highly soluble in water, and there is a high possibility of it to enter into aquatic ecosystems through runoff, and thus potentially may pose risks to aquatic organisms, [11][12] such as dropping the survival of invertebrates, [13] inducing cyanobacteria blooms [14] and so on.…”

Section: Introductionmentioning

confidence: 99%

Preparation of BiVO₄/RGO‐TNT Nanomaterials for Efficient and Recyclable Photocatalysis of Imidacloprid Insecticide

et al. 2022

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The photocatalytic composites based on BiVO4, TiO2 nanotubes (TNT) and reduced graphene oxide (RGO) were synthesized by a one‐step hydrothermal synthesis method. The properties and structures of the samples were characterized by SEM, XRD, UV‐Vis DRS, Raman spectroscopy, photoluminescence spectroscopy and XPS. The effects of RGO‐TNT loading, pH, and dosage of catalysts on degradation efficiency were tested. The best removal results were occured on the condition that loading amount of RGO‐TNT was 10 %, solution pH 10, and catalyst dosage was 1.4 g L−1. The obtained ternary composite with 10 wt% RGO‐TNT exhibited a significant enhancement in photocatalytic efficiency due to the lower band gap with enhanced light absorption and a suppression in the recombination rates of the photogenerated charge carriers, and about 73 % of imidacloprid was degraded within 30 min under UV irradiation. Furthermore, BiVO4/RGO‐TNT‐10 can be reused for 6 times without obvious catalysis loss. Trapping experiments showed that hydroxyl radicals were the main active species in the imidacloprid photocatalytic degradation, and a possible photocatalytic mechanism was proposed based on the results of trapping experiments.

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Oxidative stress and decreased dopamine levels induced by imidacloprid exposure cause behavioral changes in a neurodevelopmental disorder model in Drosophila melanogaster

Cited by 23 publications

References 72 publications

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Physiological Responses of the Firefly Pyrocoelia analis (Coleoptera: Lampyridae) to an Environmental Residue From Chemical Pesticide Imidacloprid

Preparation of BiVO₄/RGO‐TNT Nanomaterials for Efficient and Recyclable Photocatalysis of Imidacloprid Insecticide

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Oxidative stress and decreased dopamine levels induced by imidacloprid exposure cause behavioral changes in a neurodevelopmental disorder model in Drosophila melanogaster

Cited by 23 publications

References 72 publications

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Insect Body Defence Reactions against Bee Venom: Do Adipokinetic Hormones Play a Role?

Physiological Responses of the Firefly Pyrocoelia analis (Coleoptera: Lampyridae) to an Environmental Residue From Chemical Pesticide Imidacloprid

Preparation of BiVO4/RGO‐TNT Nanomaterials for Efficient and Recyclable Photocatalysis of Imidacloprid Insecticide

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Product

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Preparation of BiVO₄/RGO‐TNT Nanomaterials for Efficient and Recyclable Photocatalysis of Imidacloprid Insecticide