Oxidative stress and ferritin levels in haemodialysis patients

Şenol, Emel; Ersoy, Alpaslan; Erdinç, Selda; Sarandöl, Emre; Yurtkuran, Mustafa

doi:10.1093/ndt/gfm588

Cited by 37 publications

(31 citation statements)

References 30 publications

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“…In this study, we investigated the relationship between serum concentrations of CRP with plasma ferritin and did not found any association between them. These results conformed to Senol study (13).…”

Section: Discussionsupporting

confidence: 91%

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Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Biniaz

Shermeh

Tayebi

et al. 2014

Jundishapur J Chronic Dis Care

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Background:Clinical studies have shown that precipitation of urate crystals in joints of hyperuricemic patients could lead to systemic inflammation; however, this subject has been little explored in patients undergoing hemodialysis. Objectives: We carried out this study in order to evaluate the association of serum uric acid (SUA) levels with plasma concentrations of CRP, an inflammatory marker, and ferritin in hemodialysis patients. Materials and Methods:This cross-sectional study was conducted on 182 hemodialysis patients in two hemodialysis wards in Iran. Required laboratory parameters, including serum levels of uric acid, C-reactive protein, lipid profiles (cholesterol, triglyceride, HDL, LDL), and ferritin were measured. Demographic data were also collected with the self-report survey. P Value less than 0.05 is considered significant. Results: Higher serum levels of uric acid and CRP were seen in 44% and 47% of the patients, respectively. Hyperferritinemia was observed in 80% of participants. Although there was a significant relationship between SUA level and plasma triglyceride (P = 0.007), a linear correlation indicated that SUA level had no significant association with CRP and ferritin. Conclusions: Our results indicated that there is no statistical relationship between SUA level and CRP and serum ferritin. Detailed investigations with larger sample size are recommended.

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Section: Discussionsupporting

confidence: 91%

“…Systemic inflammation is a common disorder in patients with CKD, which results from an increase in the production of oxidative stress-free radicals and a reduction in the capacity of antioxidants (13). It exacerbates with the deterioration of kidney function and hemodialysis inception (14).…”

Section: Introductionmentioning

confidence: 99%

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Biniaz

Shermeh

Tayebi

et al. 2014

Jundishapur J Chronic Dis Care

View full text Add to dashboard Cite

show abstract

“…Decreased TAO capacity is consistent with numerous previous studies, which have shown that CRF and hemodialysis are contributing factors to oxidative stress (4,13,(32)(33)(34)(35). Previous work has demonstrated that levels of iron storage (serum ferritin) rise in HD patients (36). Increased iron content in circulation and tissues contributes to the generation of free radicals through the Fenton reaction.…”

Section: Discussionsupporting

confidence: 89%

The Relationship between Haptoglobin Polymorphism and Oxidative Stress in Hemodialysis Patients

Hamad¹,

Awadallah²,

Nasr³

2013

Journal of Medical Biochemistry

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Summary Background: The relationship between haptoglobin polymorphism and oxidative stress in hemodialysis patients is not fully understood. In this study, total antioxidant capacity and ce ru - loplasmin ferroxidase activity were evaluated in relation to haptoglobin phenotype distribution in hemodialysis patients. Methods: Serum samples collected from 161 patients and 84 healthy controls were haptoglobin-typed by electrophoresis. Ceruloplasmin ferroxidase activity and total antioxidant capacity were assayed using colorimetric methods. Results: Irrespective of the haptoglobin phenotype, patients exhibited significantly lower total antioxidant capacity (1.42± 0.29 vs. 1.55±0.28 mmol/L, P=0.002) and higher ferroxidase activity than controls. Frequency of Hp1-1 and Hp2-1 in patients was 15.5% and 36% as compared with 9.5% and 41.7% in controls. While ferroxidase activity was lower in Hp2-2 patients than in controls (142±61 vs. 179±47 U/L, P=0.002), it was higher in Hp2-1 (173±56 U/L) and Hp1-1 (170±54 U/L) patients than in controls (141±43 and 99±30 U/L respectively) (P=0.002 and 0.009). Ferroxidase activity in Hp2-2 patients was significantly lower than that of Hp2-1 or Hp1-1 patients (P=0.004 and 0.034). Total antioxidant capacity was significantly lower only in Hp2-2 patients (1.44±0.25) compared to that in Hp2-2 controls (1.65±0.22) (P=0.000). Conclusions:These findings suggest that haptoglobin polymorphism can differentially impact oxidative stress levels in hemodialysis patients.

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“…High-dose Epo and elevated SUA were considered [14] to be aggravating factors for the prognosis of heart failure hemodialysis (HD) patients. Increased oxidative stress (OS) and inflammation but similar SUA were found [15] in maintenance HD patients receiving Epo compared with healthy control subjects. Nephrectomy increased [16] the SUA variably but did not change the Epo levels.…”

Section: Discussionmentioning

confidence: 75%

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

Tsompos¹,

Panoulis

Toutouzas³

et al. 2014

Turkish Journal of Urology

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Objective: The aim of this experimental study was to assess the effect of erythropoietin on a rat model, particularly under a renal ischemia reperfusion protocol. The beneficial or lack of effects of that molecule on the excreted renal product of serum uric acid were studied biochemically. Material and methods:Forty rats were used with a mean weight of 247.7 gr. Serum uric acid levels were measured measured at 60 min after reperfusion (Groups A and C) and at 120 min after reperfusion (groups B and D). Conclusion:Erythropoietin administration, reperfusion time and their interaction have no significant shortterm alterations on serum uric acid levels. Conclusions cannot be extracted by non-significant p-values within 2 hours. Obviously, longer study times may permit safer results.

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Oxidative stress and ferritin levels in haemodialysis patients

Abstract: HD patients are in a higher oxidative state, which results in the reduction of total anti-oxidant capacity and also have an increased inflammation status. We could not find a relationship between ferritin level and OS markers in HD patients receiving erythropoietin.

Cited by 37 publications

References 30 publications

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

Relation of Serum Uric Acid With C-reactive Protein and Ferritin Levels in Patients Undergoing Hemodialysis

The Relationship between Haptoglobin Polymorphism and Oxidative Stress in Hemodialysis Patients

The effect of erythropoietin on serum uric acid levels during renal ischemia reperfusion injury in rats

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