Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms

He, Bo; Chen, Deyun; Zhang, Xiaochao; Yang, Renhua; Yang, Yuan; Chen, Peng; Zhi-qiang, Shen

doi:10.1155/2022/9299574

Cited by 40 publications

(27 citation statements)

References 118 publications

(117 reference statements)

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“…Ginsenosides have a variety of pharmacological activities, including preventing neurological diseases, increasing immune function, delaying aging, and improving sleep (Kim et al, 2018 ; Jin et al, 2021 ). Although the importance and yield of ginsenosides have been widely studied, the yield of ginsenosides remains low (Zhang et al, 2021a ; He et al, 2022 ). Therefore, it is urgent to optimize ginseng cultivation techniques and increase ginsenoside yields to meet medicinal needs.…”

Section: Introductionmentioning

confidence: 99%

Optimal NPK Fertilizer Combination Increases Panax ginseng Yield and Quality and Affects Diversity and Structure of Rhizosphere Fungal Communities

et al. 2022

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Soil microorganisms affect crop rhizospheres via the transformation and transport of nutrients, which has important influences on soil fertility, carbon sequestration, and plant yield and health in agroecosystems. There are few reports on the effects of fertilizer application on the growth of Panax ginseng (C. A. Mey.) or the structure of its rhizosphere microbial communities. In this study, an orthogonal experimental design was used to explore the effects of nine different combinations of nitrogen (N), phosphorus (P), and potassium (K) fertilizers with different amounts and proportions on ginseng growth and accumulation of ginsenosides and the structure of rhizosphere soil fungal communities. Soil without fertilization was the control. With the combined application of NPK, ginseng growth and development increased. The fertilization scheme N3P1K3, with N fertilizer at 50 g·m−2, P fertilizer at 15 g·m−2, and K fertilizer at 60 g·m−2, had the most comprehensive benefit and significantly increased ginseng rhizome biomass and ginsenoside contents (Rg1, Re, Rf, Rg2, Rb1, Ro, Rc, Rb2, Rb3, and Rd). Amplicon sequencing showed that NPK application increased the diversity of fungal communities in ginseng rhizospheres, whereas richness was bidirectionally regulated by proportions and amounts of NPK. Ascomycota was the dominant fungal phylum in ginseng rhizosphere soil, and relative abundances decreased with combined NPK application. Combined NPK application increased the relative abundance of potential beneficial fungi, such as Mortierella, but decreased that of potentially pathogenic fungi, such as Fusarium. Correlation analysis showed that potential beneficial fungi were significantly positively correlated with ginseng rhizome yield and ginsenoside contents, whereas the opposite relation was observed with potential pathogenic fungi. Thus, in addition to directly increasing crop growth, precise NPK application can also increase crop adaptability to the environment by shaping specific microbial communities. The results of this study suggest that the combined effects of biotic and abiotic processes on agricultural production determine crop yield and quality.

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Section: Introductionmentioning

confidence: 99%

Optimal NPK Fertilizer Combination Increases Panax ginseng Yield and Quality and Affects Diversity and Structure of Rhizosphere Fungal Communities

et al. 2022

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“…PNS protected HUVECs from AGE-induced injury by upregulating the expression of SIRT1 and increasing the SOD level [138]. Keap-1/Nrf2/HO-1 pathway mediated antioxidant activity of 20(S)-Rg3 and 20(R)-Rg3 in H9C2 cells [139]. Similar functions were presented in Panax ginseng C.A.…”

Section: Panax Notoginseng and Panax Ginsengmentioning

confidence: 53%

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Tan

Cheong

Cheang

2022

Oxygen

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The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes, most notably associated with cardiovascular diseases, has emerged as a major global health concern. Reactive oxygen species (ROS) play physiological functions by maintaining normal cellular redox signaling. By contrast, a disturbed balance occurring between ROS production and detoxification of reactive intermediates results in excessive oxidative stress. Oxidative stress is a critical mediator of endothelial dysfunction in obesity and diabetes. Under a hyperglycemic condition, the antioxidant enzymes are downregulated, resulting in an increased generation of ROS. Increases in ROS lead to impairment of endothelium-dependent vasodilatations by reducing NO bioavailability. Chronic treatments with antioxidants were reported to prevent the development of endothelial dysfunction in diabetic patients and animals; however, the beneficial effects of antioxidant treatment in combating vascular complications in diabetes remain controversial as antioxidants do not always reverse endothelial dysfunction in clinical settings. In this review, we summarize the latest progress in research focused on the role of ROS in vascular complications of diabetes and the antioxidant properties of bioactive compounds from medicinal plants and food in animal experiments and clinical studies to provide insights for the development of therapeutic strategies.

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“…( Hou et al, 2021 ; Liu G. et al, 2022 ). Modern pharmacology has shown that ginsenosides have neuroprotective ( Zarneshan et al, 2022 ), anti-aging ( Meng et al, 2022 ), anti-oxidant ( He et al, 2022 ), anti-inflammatory ( Xu et al, 2022 ) and anti-cancer ( Zhao L. et al, 2022 ) effects. Numerous ginsenosides has been reported have various anti-cancer activity.…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

et al. 2022

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Breast cancer (BC) is one of the most common malignant tumor, the incidence of which has increased worldwide in recent years. Ginsenosides are the main active components of Panax ginseng C. A. Mey., in vitro and in vivo studies have confirmed that ginsenosides have significant anti-cancer activity, including BC. It is reported that ginsenosides can induce BC cells apoptosis, inhibit BC cells proliferation, migration, invasion, as well as autophagy and angiogenesis, thereby suppress the procession of BC. In this review, the therapeutic effects and the molecular mechanisms of ginsenosides on BC will be summarized. And the combination strategy of ginsenosides with other drugs on BC will also be discussed. In addition, epigenetic changes, especially microRNAs (miRNAs) targeted by ginsenosides in the treatment of BC are clarified.

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Oxidative Stress and Ginsenosides: An Update on the Molecular Mechanisms

Cited by 40 publications

References 118 publications

Optimal NPK Fertilizer Combination Increases Panax ginseng Yield and Quality and Affects Diversity and Structure of Rhizosphere Fungal Communities

Optimal NPK Fertilizer Combination Increases Panax ginseng Yield and Quality and Affects Diversity and Structure of Rhizosphere Fungal Communities

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

Anti-cancer effect and potential microRNAs targets of ginsenosides against breast cancer

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