Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Bernardi, Fabiana; Guolo, Francieli; Bortolin, Thaize; Petronilho, Fabrícia; Dal‐Pizzol, Felipe

doi:10.1111/j.1447-0756.2008.00803.x

Cited by 84 publications

(62 citation statements)

References 14 publications

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“…For individual cytokines, we observed increased TNF-a and IL-6 and reduced IL-10 in the combined pre-eclampsia cohort compared with matched normal pregnancy controls; these are consistent with other published reports. [40][41][42][43][44][45][46] The imbalance between inflammatory and anti-inflammatory cytokines probably contributes to endothelial dysfunction, 47 and is therefore linked with the pathogenesis of preeclampsia…”

Section: Discussionmentioning

confidence: 99%

Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia

Xie¹,

Hu²,

Turvey

et al. 2009

BJOG

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Objective Pre-eclampsia involves a maternal inflammatory response that differs from both normal pregnancy and normotensive intrauterine growth restriction (IUGR). Our objective was to examine neutrophil Toll-like receptor (TLR), cryopyrin, nuclear factor-jB (NF-jB) subunit and interleukin-1b (IL-1b), and inflammatory cytokine profiles in women with preeclampsia or normotensive IUGR, as well as in normal pregnancy and non-pregnancy controls.Design and method A case-control study was performed. We examined the messenger RNA (mRNA) and protein expressions of TLR4 and TLR2, mRNA levels of cryopyrin, IL-1b, NF-jB subunits p50 and p65, as well as maternal serum inflammatory cytokine profiles (IL-2, IL-6, tumour necrosis factor-a [TNF-a], interferon-c [IFN-c] and IL-10) in women with and without pre-eclampsia using real-time reverse transcription polymerase chain reactions, flow cytometry and multiplex immunoassays.Setting A single tertiary maternity hospital in Vancouver, Canada.Population Women with early-onset pre-eclampsia (<34 weeks of gestation, n = 25), women with late-onset pre-eclampsia ( ‡34 +0 weeks of gestation, n = 25), women with normotensive IUGR (n = 25), women with normal pregnancy (n = 75) and non-pregnancy (n = 25) controls.Results Women with pre-eclampsia (as a single combined group of early-and late-onset, and particularly in women with earlyonset pre-eclampsia) had increased TLR2 and TLR4 mRNA and protein expressions elevated cryopyrin, NF-jB subunit, and IL-1b mRNA expression, and TNF-a:IL-10 and IL-6:IL-10 ratios compared with other groups.Conclusions These data suggest that TLRs and cryopyrin may modulate the innate immune response of the maternal syndrome of pre-eclampsia, and might also trigger the differential inflammatory response existing between early onset pre-eclampsia and normotensive IUGR.

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Section: Discussionmentioning

confidence: 99%

Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia

Xie¹,

Hu²,

Turvey

et al. 2009

BJOG

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“…The increased oxidative stress may also contribute to endothelial dysfunction and the presence of increased proinflammatory cytokines such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor (TNF) α, all of which have been linked to adverse pregnancy outcomes (17). Moreover, the studies have shown that chronic deprivation of sleeping can enhance immune response and level of inflammatory factors such as interleukin (IL-1), IL-2, IL-6, IL-10, INF-α and C-reactive protein (CRP) considerably (18)(19)(20)(21)(22). OSA with reduction of leptin level can lead to disorder in blood sugar control.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Sleep Disorders During Pregnancy and

Alihosseini

Najar

Haghighizadeh

2017

Jundishapur J Chronic Dis Care

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Background: Sleep disorder is one of the most common complaints of pregnancy that can lead to maternal and fetal complications. Objectives: The main purpose of this study is to investigate the correlation between sleep disorders of pregnancy and abortion. Methods: This study is conducted using a case-control method on 218 women in the age range of 18 -35 years old with singletonpregnancy passing their first or second pregnancy in Ahvaz, Iran. Continuous sampling was conducted on the basis of characteristics of the research unit. The case group (n = 109) included women hospitalized because of an abortion, and the control group (n = 109) consists of pregnant women above 22 weeks, who were referred to healthcare centers to get pregnancy cares. The data collection was done using a demographic questionnaire and pittsburgh sleep quality index (PSQI). Data analysis was performed using SPSS-22 and t-test for quantitative variables and Chi-Square for qualitative variables. Results: Obtained results from the study showed that there is a significant relationship between abortion and sleep duration (P = 0.000), subjective sleep quality (P = 0.000), sleep latency (P = 0.000), habitual sleep efficiency (P = 0.000), sleep disturbances (P = 0.000), daytime dysfunction (P = 0.000), and total valued of sleep disorder (P = 0.000). However, the correlation was insignificant in case of use of sleeping medication (P = 0.233). Conclusions: According to the obtained results, there is a significant correlation between sleep disorder and abortion. Therefore, training sleep health and suitable consultations during pregnancy would be effective in field of preventing abortion and with the aim of achieving to safe pregnancy.

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“…Whereas some studies showed nutrients may be involved in several important steps in the current proposed concepts of the pathogenesis of PE (31). The underlying mechanisms are complex and remain unclear (8)(9)(10). To date there has been controversial results in this issue.…”

Section: Discussionmentioning

confidence: 93%

“…Despite extensive studies and recent evidence to identify the pathophysiology of PE, the etiology of this disorder is questionable and requires further investigation (8). Disturbed placentation, endothelial dysfunction, oxidative stress and a low-grade systemic inflammatory condition are related to the diagnostic criteria for PE, leading to the clinical signs including hypertension, proteinuria and edema after the twentieth week of pregnancy (9,10).…”

Section: Introductionmentioning

confidence: 99%

Nutritional Status in Preeclamptic Women: a Case-Control Study in South East of Iran

et al. 2018

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A B S T R A C T Background and Objectives:Beyond the influence of anthropometric, demographic and race, nutrition is considered as one of the most important risk factors for development of preeclampsia (PE). The issue has grown controversial in light of recent reports. This paper, purposes to compare the nutritional and demographic status between PE women and normal pregnancy in south east of Iran. Materials and Methods:Sixty three normal pregnant and 62 PE women were recruited to be referred to obstetrics and gynecology department of Imam-Ali Hospital, Zahedan, Iran. PE was diagnosed by using international guidelines by the expert gynecologist. Dietary intake, assessed by food frequency questionnaire (FFQ), and anthropometric measurement and medical history were collected by trained gynecologist and dietitians during the second trimester. The logistic regression model was used to assess the correlation between dietary intake and PE risk.Results: Pregnant PE women compared with normal pregnant women had higher pre-pregnancy body mass index (BMI), cesarean delivery and low birth weight babies. There was an association between grain intake and PE risk (OR= 2.00;. No association was found between other dietary intakes and PE risk. Conclusions:Our findings support the association between grain intake and the risk of PE. Further prospective studies are needed to illustrate the link between dietary intake and PE status.

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Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Cited by 84 publications

References 14 publications

Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia

Toll‐like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre‐eclampsia

The Relationship Between Sleep Disorders During Pregnancy and

Nutritional Status in Preeclamptic Women: a Case-Control Study in South East of Iran

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