Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes

Murray, Ashley R.; Kisin, Elena R.; Leonard, Steve; Young, Shih‐Houng; Kommineni, Choudari; Kagan, Valerian E.; Castranova, Vincent; Shvedova, Anna A.

doi:10.1016/j.tox.2008.12.023

Cited by 318 publications

(184 citation statements)

References 79 publications

Supporting

Mentioning

173

Contrasting

Unclassified

Order By: Relevance

“…In vivo studies with dermal exposure of CNT have shown inflammation and inflammatory granuloma formation in dermal and subcutaneous tissues (Yokoyama, Sato et al 2004;Koyama, Endo et al 2006). Other studies have also shown that exposure to CNT can induce dermal granuloma formation, thickness of skin folding and neutrophil and macrophage-mediated inflammation (Sato, Yokoyama et al 2005;Murray, Kisin et al 2009). …”

Section: Skin Exposurementioning

confidence: 98%

“…It is an imbalance between antioxidant proteins and ROS produced in cells and induced by toxic substances such as asbestos (Liu, Ernst et al 2000). CNT have been found to induce oxidative stress and ROS in the lung (Manna, Sarkar et al 2005;Shvedova, Kisin et al 2005;Pacurari, Yin et al 2008), skin (Murray, Kisin et al 2009), and heart (Li, Hulderman et al 2007). Metal contaminants such as Fe are the major source of ROS generation induced by CNT.…”

Section: Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Biological Activities of Carbon Nanotubes

Mishra¹,

Rojanasakul²,

Wang³

2012

The Delivery of Nanoparticles

View full text Add to dashboard Cite

Section: Skin Exposurementioning

confidence: 98%

Section: Oxidative Stressmentioning

confidence: 99%

Biological Activities of Carbon Nanotubes

Mishra¹,

Rojanasakul²,

Wang³

2012

The Delivery of Nanoparticles

View full text Add to dashboard Cite

“…[16][17][18][19] CNTs can elicit toxicity through membrane damage, DNA damage, oxidative stress, changes in mitochondrial activities, altered intracellular metabolic routes, and protein synthesis. 10,[20][21][22][23][24] The most common mechanisms of CNT cytotoxicity also encompass apoptosis and necrosis. [25][26][27] However, CNT cytotoxicity is significantly controversial, with a large number of studies reporting altered toxic responses to CNTs both in vitro and in vivo.…”

Section: Toxicity Of Carbon Nanotubesmentioning

confidence: 99%

Functionalized carbon nanotubes: biomedical applications

Vardharajula¹,

Ali²,

Tiwari³

et al. 2012

IJN

185

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in muchreduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.

show abstract

“…Murray et al [133] concluded that unpurified singlewalled carbon nanotubes may give rise to skin inflammation, presumably linked to the generation of reactive oxygen species which is favored by the presence of metal residues in unpurified nanotubes.…”

Section: Human Health Hazards Following From Dermal Exposure To Persimentioning

confidence: 99%

“…From the studies regarding skin exposure to nanoparticles [7,16,109,[117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133] several likely determinants of hazard emerge. These include size, chemical composition, surface characteristics, such as surface coating and surface charge, and crystalline structure.…”

Section: Human Health Hazards Following From Dermal Exposure To Persimentioning

confidence: 99%

Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

View full text Add to dashboard Cite

Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

show abstract

Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes

Cited by 318 publications

References 79 publications

Biological Activities of Carbon Nanotubes

Biological Activities of Carbon Nanotubes

Functionalized carbon nanotubes: biomedical applications

Human health hazards of persistent inorganic and carbon nanoparticles

Contact Info

Product

Resources

About