Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease

Leo, Maria Emilia De; Borrello, Silvia; Passantino, Massimo; Palazzotti, Bernardetta; Mordente, Alvaro; Daniele, Antonio; Filippini, V.; Galeotti, T.; Masullo, Carlo

doi:10.1016/s0304-3940(98)00469-8

Cited by 91 publications

(33 citation statements)

References 18 publications

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“…Schlicht and colleagues propose to interpret their finding of SOD2 in the PFC of suicide subjects as a compensatory mechanism under the conditions of intensified oxidative stress. This corresponds well with the reports of elevated levels of this enzyme in different psychiatric disorders [34, 43–45]. On the other hand, a study by Pae et al [46] failed to support an association of manganese superoxide dismutase (one of the antioxidant enzyme) gene polymorphism (MnSOD: Ala-9Val) with the development of mood disorders or their clinical parameters in the Korean population.…”

Section: Introductionsupporting

confidence: 89%

The neurobiology of suicide - A Review of post-mortem studies

et al. 2013

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The neurobiology of suicidal behaviour, which constitutes one of the most serious problems both in psychiatry and general medical practice, still remains to a large degree unclear. As a result, scientists constantly look for new opportunities of explaining the causes underlying suicidality. In order to elucidate the biological changes occurring in the brains of the suicide victims, studies based on post-mortem brain tissue samples are increasingly being used. These studies employ different research methods to provide an insight into abnormalities in brain functioning on various levels, including gene and protein expression, neuroplasticity and neurotransmission, as well as many other areas. The aim of this paper to summarize the available data on the post-mortem studies, to provide an overview of main research directions and the most up-to-date findings, and to indicate the possibilities of further research in this field.

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Section: Introductionsupporting

confidence: 89%

The neurobiology of suicide - A Review of post-mortem studies

et al. 2013

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“…Several studies find no difference in SOD between AD and controls [15, 29, 31, 36, 66]. Some find significantly lower erythrocyte level [5, 11, 54, 67] and plasma/serum level [11, 26] in AD, while others find significantly higher erythrocyte [6, 7, 21, 22, 68–71] and plasma [28] levels in AD. However, only three among these studies have a case number more than 80 [7, 22, 68] and all of them either include only mild-to-moderate AD [22, 68] or have clear severity-classification of AD [7].…”

Section: Resultsmentioning

confidence: 99%

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Chang

Tsai

et al. 2014

BioMed Research International

117

116

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Purpose. Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods. PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion. Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

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“…Patients with the mentioned neurological diseases showed significantly increased (with respect to controls) plasma levels of TBARS (24, 20, and 19%, respectively), significantly decreased plasma TRAP capacity (32,25, and 28%, respectively) and significantly increased SOD activity in red blood cells (73, 63, and 55%, respectively) with unchanged erythrocyte CAT and GPx activities ( Table 1). The differences in plasma TBARS and TRAP levels and in erythrocyte SOD between the control healthy subjects and the neurological patients with either Alzheimer's disease, vascular dementia or Parkinson disease are highly significant, specially after considering that [35][36][37] and TRAP [38,39]; and for erythrocyte SOD [36][37][38][40][41][42], CAT [36,37,42,43] and GPx activities [36,37,43,44].…”

Section: Resultsmentioning

confidence: 99%

Systemic Oxidative Stress Associated with the Neurological Diseases of Aging

et al. 2009

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Markers of oxidative stress were measured in blood samples of 338 subjects (965 observations): Alzheimer's, vascular dementia, diabetes (type II) superimposed to dementias, Parkinson's disease and controls. Patients showed increased thiobarbituric acid reactive substances (+21%; P < 0.05), copper-zinc superoxide dismutase (+64%; P < 0.001) and decreased antioxidant capacity (-28%; P < 0.001); pairs of variables resulted linearly related across groups (P < 0.001). Catalase and glutathione peroxidase, involved in discrimination between diseases, resulted non-significant. When diabetes is superimposed with dementias, changes resulted less marked but significant. Also, superoxide dismutase resulted not linearly correlated with any other variable or age-related (pure Alzheimer's peaks at 70 years, P < 0.001). Systemic oxidative stress was significantly associated (P << 0.001) with all diseases indicating a disbalance in peripheral/adaptive responses to oxidative disorders through different free radical metabolic pathways. While other changes - methionine cycle, insulin correlation - are also associated with dementias, the responses presented here show a simple linear relation between prooxidants and antioxidant defenses.

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Oxidative stress and overexpression of manganese superoxide dismutase in patients with Alzheimer's disease

Cited by 91 publications

References 18 publications

The neurobiology of suicide - A Review of post-mortem studies

The neurobiology of suicide - A Review of post-mortem studies

The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Systemic Oxidative Stress Associated with the Neurological Diseases of Aging

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