Oxidative Stress and Skin Fibrosis

Abstract

Fibrosis is defined as increased fibroblast proliferation and deposition of extracellular matrix components with potential clinical ramifications including organ dysfunction and failure. Fibrosis is a characteristic finding of various skin diseases which can have life-threatening consequences. These implications call for research into this topic as few treatments targeting fibrosis are available. In this review, we discuss oxidative stress and its role in skin fibrosis. Recent studies have implicated the importance of oxidative stress in a variety of cellular pathways directly and indirectly involved in the pathogenesis of skin fibrosis. The cellular pathways by which oxidative stress affects specific fibrotic skin disorders are also reviewed. Finally, we also describe various therapeutic approaches specifically targeting oxidative stress to prevent skin fibrosis. We believe oxidative stress is a relevant target, and understanding the role of oxidative stress in skin fibrosis will enhance knowledge of fibrotic skin diseases and potentially produce targeted therapeutic options.

Effect of Topical Application of Black Seed Oil on Imiquimod‐Induced Psoriasis‐like Lesions in the Thin Skin of Adult Male Albino Rats

“…An increase in collagen and elastic fibers has been associated with abundant inflammatory infiltrates. Dysfunction and damage of mitochondria caused by reactive oxygen species with lipid peroxidation products together with activation of inflammatory cells resulted in fibrosis and collagen deposition (Shroff et al, 2014). The present work shows that collagen fiber deposition was decreased in group III treated with black seed oil, which might be related to the antiinflammatory and antioxidative effects of N. Sativa (Kundu et al, 2013;Amin and Hosseinzadeh, 2016).…”

Antifibrotic Activity of Acylated and Unacylated Ghrelin

“…In addition, macrophages release tumor necrosis factor- α (TNF- α ) and interleukin-1 β (IL-1 β ) that promote fibroblast activation and fibrotic tissue deposition [ 2 ]. Tissue damage and inflammation increase reactive oxygen species (ROS) production, which, in turn, contributes to fibrosis, enhancing the secretion of fibrogenic factors [ 8 ].…”

Simultaneous analysis of multiple urinary biomarkers for the evaluation of oxidative stress by automated online in‐tube solid‐phase microextraction coupled with negative/positive ion‐switching mode liquid chromatography–tandem mass spectrometry

“…ROS can damage cellular membranes, lipids, nucleic acids, proteins, and enzymes [1][2][3][4][5]. Oxidative stress may enhance the aging process [6,7] and can trigger various diseases [8,9], Article Related Abbreviations: 3-NT, 3-nitro-L-tyrosine; 8-IP, 8-isoprostane; 8-OHdG, 8-hydroxy-2 ′ -deoxyguanosine; IS, internal standard; MRM, multiple reaction monitoring; ROS, reactive oxygen species including inflammation [10], cancers [11][12][13], cardiovascular disease [9,14], essential hypertension [15], chronic obstructive pulmonary disease [16], skin fibrosis [17], diabetes [18], neurodegenerative diseases [19], and Alzheimer's disease [20]. Early diagnosis of these conditions is crucial in maintaining human health and for successful therapy, indicating a need to reliably and quantitatively measure biomarkers of oxidative stress.…”