Oxidative Stress and Space Biology: An Organ-Based Approach

Goodwin, Thomas J.; Christofidou‐Solomidou, Melpo

doi:10.3390/ijms19040959

Cited by 42 publications

(35 citation statements)

References 17 publications

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“…It is also important to question the mechanism that contributes to or underlies the 12 C irradiation-induced transient decrease in DG neurogenesis. Given the large literature on HZE particle irradiation and oxidative stress [ 26 , 71 , 88 , 93 , 113 , 114 , 167 , 168 , 169 , 170 ], a reasonable hypothesis is that oxidative stress and/or damage may play a role. Previously, we have reported indices of genomic instability in the DG GCL of mice seven days and two-mon post- 56 Fe IRR [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Whole-Body 12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but Does Not Change New Neuron Survival Rate

Zanni

Deutsch

Rivera

et al. 2018

IJMS

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High-charge and -energy (HZE) particles comprise space radiation and they pose a challenge to astronauts on deep space missions. While exposure to most HZE particles decreases neurogenesis in the hippocampus—a brain structure important in memory—prior work suggests that 12C does not. However, much about 12C’s influence on neurogenesis remains unknown, including the time course of its impact on neurogenesis. To address this knowledge gap, male mice (9–11 weeks of age) were exposed to whole-body 12C irradiation 100 cGy (IRR; 1000 MeV/n; 8 kEV/µm) or Sham treatment. To birthdate dividing cells, mice received BrdU i.p. 22 h post-irradiation and brains were harvested 2 h (Short-Term) or three months (Long-Term) later for stereological analysis indices of dentate gyrus neurogenesis. For the Short-Term time point, IRR mice had fewer Ki67, BrdU, and doublecortin (DCX) immunoreactive (+) cells versus Sham mice, indicating decreased proliferation (Ki67, BrdU) and immature neurons (DCX). For the Long-Term time point, IRR and Sham mice had similar Ki67+ and DCX+ cell numbers, suggesting restoration of proliferation and immature neurons 3 months post-12C irradiation. IRR mice had fewer surviving BrdU+ cells versus Sham mice, suggesting decreased cell survival, but there was no difference in BrdU+ cell survival rate when compared within treatment and across time point. These data underscore the ability of neurogenesis in the mouse brain to recover from the detrimental effect of 12C exposure.

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Section: Discussionmentioning

confidence: 99%

Whole-Body 12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but Does Not Change New Neuron Survival Rate

Zanni

Deutsch

Rivera

et al. 2018

IJMS

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“…In normal conditions, there is a dynamic balance between oxidant production and antioxidant defense in the body, termed redox homeostasis. However, spaceflight can cause the imbalance of redox homeostasis in human and animal blood, urine, and tissues [ 49 ].…”

Section: Iron Overload and Its Link To Spaceflight-induced Oxidatimentioning

confidence: 99%

“…Space radiation is another major feature of the space environment, and it is a strong stimulus for oxidative stress [ 49 ]. Space-relevant radiation can induce oxidative damage in various tissues of rodents.…”

Section: Iron Overload and Its Link To Spaceflight-induced Oxidatimentioning

confidence: 99%

Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models

Yang

Zhang

Dong

et al. 2018

IJMS

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The space environment chiefly includes microgravity and radiation, which seriously threatens the health of astronauts. Bone loss and muscle atrophy are the two most significant changes in mammals after long-term residency in space. In this review, we summarized current understanding of the effects of microgravity and radiation on the musculoskeletal system and discussed the corresponding mechanisms that are related to iron overload and oxidative damage. Furthermore, we enumerated some countermeasures that have a therapeutic potential for bone loss and muscle atrophy through using iron chelators and antioxidants. Future studies for better understanding the mechanism of iron and redox homeostasis imbalance induced by the space environment and developing the countermeasures against iron overload and oxidative damage consequently may facilitate human to travel more safely in space.

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“…The transcription factor OCT1 is frequently upregulated in cancer. Recent experimental studies have demonstrated its role in the silencing of oxidative phosphorylation and switching to aerobic glycolysis [53]. Additionally, an oncogenic transcription factor, Yin Yang 1 (YY1), promotes aerobic glycolysis via upregulation of GLUT3 [54].…”

Section: Molecular View Into the Warburg Effectmentioning

confidence: 99%

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

et al. 2020

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The Warburg effect is characterised by increased glucose uptake and lactate secretion in cancer cells resulting from metabolic transformation in tumour tissue. The corresponding molecular pathways switch from oxidative phosphorylation to aerobic glycolysis, due to changes in glucose degradation mechanisms known as the 'Warburg reprogramming' of cancer cells. Key glycolytic enzymes, glucose transporters and transcription factors involved in the Warburg transformation are frequently dysregulated during carcinogenesis considered as promising diagnostic and prognostic markers as well as treatment targets. Flavonoids are molecules with pleiotropic activities. The metabolism-regulating anticancer effects of flavonoids are broadly demonstrated in preclinical studies. Flavonoids modulate key pathways involved in the Warburg phenotype including but not limited to PKM2, HK2, GLUT1 and HIF-1. The corresponding molecular mechanisms and clinical relevance of 'anti-Warburg' effects of flavonoids are discussed in this review article. The most prominent examples are provided for the potential application of targeted 'anti-Warburg' measures in cancer management. Individualised profiling and patient stratification are presented as powerful tools for implementing targeted 'anti-Warburg' measures in the context of predictive, preventive and personalised medicine.

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Oxidative Stress and Space Biology: An Organ-Based Approach

Abstract: The environment of space provides many challenges to the human physiology and therefore to extended habitation and exploration[...]

Cited by 42 publications

References 17 publications

Whole-Body 12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but Does Not Change New Neuron Survival Rate

Whole-Body 12C Irradiation Transiently Decreases Mouse Hippocampal Dentate Gyrus Proliferation and Immature Neuron Number, but Does Not Change New Neuron Survival Rate

Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

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