Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Dumitrescu, Laura; Popescu-Olaru, Iulia; Cozma, Liviu; Tulbă, Delia; Hinescu, Mihail Eugen; Ceafalan, Laura Cristina; Gherghiceanu, Mihaela; Popescu, Bogdan Ovidiu

doi:10.1155/2018/2406594

Cited by 169 publications

(134 citation statements)

References 74 publications

(209 reference statements)

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“…A pivotal pathogenic factor, oxidative stress (OS) has been shown to contribute to the development of AD. In the CNS, the reactive oxygen species (ROS) levels and inflammation can be enhanced by a microbiota type to favors abnormal aggregation of Aβ, which speculated that high levels of CNS OS may be due to gut dysbiosis or its consequence (Jones et al, 2012 ; Dumitrescu et al, 2018 ). In short, it can be seen from the above results and summarized as follows: (1) chronic bacterial infections as a possible etiology linking AD pathogenesis; (2) obvious alteration in the compositions of gut microbiome in AD; and (3) rising proinflammatory and lowering anti-inflammatory bacteria in the gut related to systemic inflammation in the patients suffering from the brain amyloidosis and cognitive impairment, which changes might impact brain functions.…”

Section: Dysbiosis Of Gut Microbes In Ad Patients and Its Animal Modementioning

confidence: 99%

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease

Zhu

Chu

et al. 2020

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is commonly an age-associated dementia with neurodegeneration. The pathogenesis of AD is complex and still remains unclear. The inflammation, amyloid β (Aβ), and neurofibrillary tangles as well misfolded tau protein in the brain may contribute to the occurrence and development of AD. Compared with tau protein, Aβ is less toxic. So far, all efforts made in the treatments of AD with targeting these pathogenic factors were unsuccessful over the past decades. Recently, many studies demonstrated that changes of the intestinal environment and gut microbiota via gut–brain axis pathway can cause neurological disorders, such as AD, which may be involved in the pathogenesis of AD. Thus, remodeling the gut microbiota by various ways to maintain their balance might be a novel therapeutic strategy for AD. In the review article, we analyzed the characteristics of gut microbiota and its dysbiosis in AD and its animal models and investigated the possibility of targeting the gut microbiota in the treatment of the patients with AD in the future.

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Section: Dysbiosis Of Gut Microbes In Ad Patients and Its Animal Modementioning

confidence: 99%

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease

Zhu

Chu

et al. 2020

Front. Aging Neurosci.

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“…Molecular oxygen (O 2 ) is considered to be a driver of gut dysbiosis [24] and we know gut microbes contribute to redox signaling [25]. The gut microbiota oxidation-reduction potential, e.g., capacity for the microbiota to gain electrons, also influences the homeostasis of the intestinal-blood barrier [10], while at the level of the brain and CNS, modulates intestinal ROS levels via the vagal, cholinergic and anti-inflammatory pathways [26,27]. Further, oxidative and inflammatory stress can lead to distal breaches for other immune privileged barriers in humans [3].…”

Section: Gut Redox Pairs and The French Paradoxmentioning

confidence: 99%

The Microbiota–Gut–Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota

Obrenovich

Siddiqui

McCloskey³

et al. 2020

Microorganisms

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It has been well established that a vegetarian and polyphenol-rich diet, including fruits, vegetables, teas, juices, wine, indigestible fiber and whole grains, provide health-promoting phytochemicals and phytonutrients that are beneficial for the heart and brain. What is not well-characterized is the affect these foods have when co-metabolized within our dynamic gut and its colonizing flora. The concept of a heart shunt within the microbiota-gut-brain axis underscores the close association between brain and heart health and the so-called “French paradox” offers clues for understanding neurodegenerative and cerebrovascular diseases. Moreover, oxidation-redox reactions and redox properties of so-called brain and heart-protective foods are underappreciated as to their enhanced or deleterious mechanisms of action. Focusing on prodromal stages, and common mechanisms underlying heart, cerebrovascular and neurodegenerative diseases, we may unmask and understanding the means to better treat these related diseases.

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“…Oxidative stress also plays a role in regulating the microbiome-gut-brain axis related to ischemia and depression (Figure 1 L). Intestinal microbiome might increase ROS and promote abnormal protein aggregation and brain lesions, which can result in alteration of gut properties and microbiota [138]. For instance, ischemic stroke intensifies gut barrier breakdown by overproduced ROS and aggravates microbiota alterations, followed by the translocation of a selective bacterial strain to the surrounding tissues.…”

Section: Microbiome-gut-brainmentioning

confidence: 99%

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

Lin

Wang

Yan

et al. 2019

Oxidative Medicine and Cellular Longevity

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The public health sector faces a huge challenge as a result of the high prevalence and burden of disability caused by ischemic cardio-cerebrovascular disease (CVD) and depression. Although studies have explored the underlying mechanisms and potential therapies to address conditions, there is no treatment breakthrough, especially for depression which is highly influenced by social stressors. However, accumulating evidence reveals that CVD and depression are correlated and share common risk factors, particularly obesity, diabetes, and hypertension. They also share common mechanisms, including oxidative stress (OS), inflammation and immune response, cell death signaling pathway, and microbiome-gut-brain axis. This review summarizes the relationship between ischemic CVD and depression and describes the interactions among common risk factors and mechanisms for these two diseases. In addition, we propose that OS mediates the crosstalk between these diseases. We also reveal the potential of antioxidants to ameliorate OS-related injuries.

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Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Cited by 169 publications

References 74 publications

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease

Target Dysbiosis of Gut Microbes as a Future Therapeutic Manipulation in Alzheimer’s Disease

The Microbiota–Gut–Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

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