Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People

Sakano, Noriko; Wang, Da Hong; Takahashi, Noriko; Wang, Bingling; Sauriasari, Rani; Kanbara, Sakiko; Sato, Yousuke; Takigawa, Tomoko; Takaki, Jiro; Oginö, Kazuhíde

doi:10.3164/jcbn.08-252

Cited by 122 publications

(130 citation statements)

References 46 publications

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“…Many studies have found a negative correlation between urinary 8-OHdG excretion and BMI. [17][18][19] However, we did not find such an association in our study, possibly because of the wide distribution of urinary 8-OHdG levels or our small sample size. Systemic oxidative DNA damage was greater in morbidly obese patients, but this increase was not related to weight gain and was more evident in serum than urine samples.…”

Section: Discussioncontrasting

confidence: 51%

The effects on oxidative DNA damage of lapa roscopic gastric band applications in morbidly obese patients

et al. 2014

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Background: Obesity may induce oxidative stress, causing oxidative damage of DNA. We examined associations between decreasing serum and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and weight loss in morbidly obese patients before and 6 months after laparoscopic adjustable gastric banding (LAGB). Methods:We compared patients who had surgery for morbid obesity with healthy, nonobese controls. Urine and fasting blood samples were collected once from the controls and from the morbidly obese patients before and 6 months after the LAGB. The serum and urinary 8-OHdG levels were evaluated in these groups using an enzyme-linked immunosorbent assay kit. Results:We included 20 patients who had surgery for morbid obesity (8 men, 12 women, mean body mass index [BMI] 46.82 ± 4.47) and 20 healthy, nonobese people (10 men, 10 women, mean BMI 22.52 ± 2.08) in our study. There was no significant difference in serum 8-OHdG levels between the groups, whereas urinary 8-OHdG levels were significantly higher in morbidly obese patients than in controls. Weight, BMI and serum and urinary 8-OHdG levels were significantly decreased in morbidly obese patients 6 months after LAGB. Conclusion:The LAGB provides efficient weight loss in patients with morbid obesity. The systemic oxidative DNA damage was increased by the morbid obesity, but this increase was not related to weight gain, and it was more evident in serum than urine samples. After LAGB for morbid obesity, the oxidative DNA damage declined both in serum and urine.

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Section: Discussioncontrasting

confidence: 51%

The effects on oxidative DNA damage of lapa roscopic gastric band applications in morbidly obese patients

et al. 2014

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“…Overall, shortened LTL mirrors the cell's mitotic history and replicative history of hematopoietic stem cells, and is further subjected to the effects of inflammation and oxidation (36,37,64). Interestingly, as prior reports show, there are gender-specific effects of oxidative stress and inflammation markers in response to psychological stress, lifestyle, and disease (33,65,66). Although estrogen was shown to have antioxidant neuroprotective effects in response to stress for females (45,67), young women may be more sensitive to psychological stress (30).…”

Section: Discussionmentioning

confidence: 83%

Delay discounting, genetic sensitivity, and leukocyte telomere length

Yim

Zhang

Shalev

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, is negatively associated with LTL. The relationship is robust after controlling for health-related variables, as well as risk attitude-another important determinant of decision making. LTL in females is more sensitive to impatience than in males. We then asked if genes possibly modulate the effect of impatient behavior on LTL. The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor β gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females. The current results contribute to understanding the relationship between preferences in decision making, particularly impatience, and cellular aging, for the first time to our knowledge. Notably, oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who tend to make impatient choices.telomere length | delay discounting | risk attitude | oxytocin receptor | estrogen receptor

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“…The standard level of urinary 8-OHdG (corrected by the Cre level) employed as a stress marker, as provided by the manufacturer of the measurement kit, is 8.4 ng/mg Cre [16], and that reported as the standard for healthy adults is 15.7 ng/mg Cre [3]. The urinary 8-OHdG in the elderly disaster victims was slightly lower than that in healthy subjects aged 60 years or older [17] and higher than that in healthy subjects aged 40 years or older [18].…”

Section: Discussionmentioning

confidence: 99%

“…While some studies reported a rise in urinary 8-OHdG level with age [10,18,21], other studies found no agerelated difference [19]. In terms of an association between gender and urinary 8-OHdG level, urinary 8-OHdG has been reported to be higher in males than in females [9,10,14], but the gender difference was resolved after correction by the creatinine level [3].…”

Section: Discussionmentioning

confidence: 99%

Association of urinary 8-OHdG with lifestyle and body composition in elderly natural disaster victims living in emergency temporary housing

Saito

Aoki

Fujiwara

et al. 2012

Environ Health Prev Med

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Objectives Residents who lost land and houses due to disasterous heavy rainfall-related events on July 13, 2004 and the Chuetsu Earthquake on October 23, 2004 were moved to emergency temporary housing. The change in life style due to living under such conditions is assumed to increase oxidative stress level. In this study, we investigated the oxidative stress level in elderly residents of emergency temporary housing, and analyzed its association with lifestyle and body composition following these disasters. Methods A noninvasive oxidative stress marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), and body composition were measured in 73 elderly residents of emergency temporary housing. Results In the elderly female residents, the urinary 8-OHdG level tended to decrease with time after the disasters. 8-OHdG levels were slightly higher in females than males and significantly higher among those who exercised regularly compared to those who did not, particularly in females. A weak correlation was noted between the urinary 8-OHdG level and muscle ratio in females. Conclusions The in vivo oxidative stress level in our study cohort of elderly residents of emergency temporary housing changed following the change in life style, but remained within the normal range. The increase in oxidative stress levels of elderly females was related to menopause. A decrease in estrogen levels due to menopause inhibits its antioxidant effects, which increases 8-OHdG levels. Although it is difficult to determine, a decrease in daily stressors over time following the disaster could be a cause of the decrease in oxidative stress levels. We suggest that the close evaluation of the stress level of disaster victims is desirable, in combination with evidence of antioxidative substances and the psychosocial influence of suffering as a consequence of the disaster.Keywords Disaster Á Emergency temporary housing Á 8-Hydroxy-2 0 -deoxyguanosine Á In vivo oxidative stress Á Elderly

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Oxidative Stress Biomarkers and Lifestyles in Japanese Healthy People

Cited by 122 publications

References 46 publications

The effects on oxidative DNA damage of lapa roscopic gastric band applications in morbidly obese patients

The effects on oxidative DNA damage of lapa roscopic gastric band applications in morbidly obese patients

Delay discounting, genetic sensitivity, and leukocyte telomere length

Association of urinary 8-OHdG with lifestyle and body composition in elderly natural disaster victims living in emergency temporary housing

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