Oxidative stress biomarkers in endometrial secretions: A comparison between successful and unsuccessful in vitro fertilization cycles

Rahiminejad, Mohammad Ehsan; Moaddab, Amirhossein; Ganji, Maziar; Eskandari, Nika; Yepez, M.; Rabiee, Soghra; Wise, Meredith; Ruano, Rodrigo; Ranjbar, Akram

doi:10.1016/j.jri.2016.05.003

Cited by 27 publications

(18 citation statements)

References 44 publications

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“…Oxidative stress also takes its toll on uterine function, and measures of oxidative stress in uterine fluid aspirated from women before transfer of in vitro fertilized embryos were correlated with pregnancy outcomes. Women in whom clinical pregnancies were established had less evidence of uterine oxidative damage than those in whom in vitro fertilization was unsuccessful in establishing pregnancy (Rahiminejad et al, 2016).…”

Section: Oxidative Stress Contributes To Infertilitymentioning

confidence: 97%

“…One potential mechanism might be persistent oxidative stress in the uterus. Rahiminejad et al (2016) reported that pregnancy rates were lower in human IVF patients with markers of oxidative damage in uterine fluid at the time of embryo transfer. Other explanations include inappropriate ability of the endometrium to engage in the required cross talk with the conceptus for successful establishment of pregnancy, as has been observed in other forms of infertility (Moraes et al, 2018).…”

Section: Uterine Effects Of Inflammationmentioning

confidence: 99%

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Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract

Gilbert

2019

Journal of Dairy Science

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Section: Oxidative Stress Contributes To Infertilitymentioning

confidence: 97%

Section: Uterine Effects Of Inflammationmentioning

confidence: 99%

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract

Gilbert

2019

Journal of Dairy Science

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“…Many studies have reported the effects of a variety of ROS and antioxidants in FF on IVF outcomes, although the results are controversial (19)(20)(21)(22)(23). In this study, GSH-Px, SOD and Prdx4 were all strongly correlated with the clinical pregnancy outcome (Table 2).…”

Section: Discussionmentioning

confidence: 63%

Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes

et al. 2020

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Background: Peroxiredoxin 4 (Prdx4), a member of the Prdx family, can catalyze the reduction of reactive oxygen species. This study aims to explore whether Prdx4 can serve as an effective marker in follicular fluid (FF) for predicting in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes.Methods: In this prospective study, all participants were recruited from the center of clinical reproductive medicine from 2017 September to 2018 December. Women with tubal or male factor infertility undergoing their first IVF/ICSI cycle were recruited (n=138). FF samples from each patient were collected on the day of oocyte retrieval. Prdx4 concentrations were measured, and the correlation between Prdx4 levels and IVF outcomes was analyzed. Results:The results showed that pregnant women had higher levels of Prdx4 than nonpregnant women.Prdx4 was positively correlated with the oocyte fertilization rate (r =0.334; P=0.011) and good quality embryo rate (r =0.326; P=0.013). Furthermore, we found that the clinical pregnancy rate was positively correlated with Prdx4 levels in a concentration-dependent manner in the Prdx4 quartiles (<13.38, 13.83-16.93, 16.93-22.93, >22.93 ng/mL). The fertilization rates, clinical pregnancy rates and live pregnancy rates were all significantly higher in the highest Prdx4 quartile group than in the lowest quartile. Moreover, the results indicated that Prdx4 had an area under the receiver operating characteristic curve (AUC) of 0.754, corresponding to an optimal cutoff point of 22.30 ng/mL. Conclusions: Our results provide evidence that higher expression of antioxidants, such as Prdx4, in the FF of IVF patients tends to indicate a higher likelihood of pregnancy through an oocyte quality mechanism.

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“…Endometriyal reseptivitenin irdelenmesinde ultrasonografik [28][29][30][31] ve histeroskopik [32][33][34][35] değerlendirmenin yapıldığı klinik yöntemlerin yanı sıra endometriyal sıvı aspiratının [36][37][38][39][40] ve endometriyal doku biopsisinin [41][42][43][44] değerlendirildiği histolojik, serolojik ve moleküler birçok çalışma mevcuttur. EMK ölçümü, endometriyal reseptivitenin ultrasonografik göstergelerinden en çok araştırılan parametre olmuştur.…”

Section: Discussionunclassified

İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi

Çabuş¹,

Çil²,

Kabukçu³

2021

Pamukkale Medical Journal

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ÖzAmaç: Çalışmamızın amacı, yardımcı üreme tekniği olarak intrasitoplazmik sperm enjeksiyonu uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesidir. Gereç ve yöntem: Ocak 2018 ve Aralık 2020 tarihleri arasında, intrasitoplazmik sperm enjeksiyonu uygulanan, tek ve taze embriyo transferinin yapıldığı toplam 283 infertil hastaya ait 325 siklus çalışmaya dâhil edildi. Hastaların yaşı, vücut kitle indeksleri, infertilite nedenleri, kaç adet oosit toplandığı ve maturasyon oranı, embriyo transfer günü endometriyal kalınlık, embriyonun kalitesi ve kaçıncı gün transfer edildiği belirlendi. Ayrıca hastaların Anti-Müllerian Hormon (AMH), bazal FSH, LH, estradiol (E2) düzeyleri, Human Chorionic Gonadotropin (hCG) uygulandığı gün E2 ile progesteron (P) düzeyleri ve gebelik sonuçları değerlendirildi.

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Oxidative stress biomarkers in endometrial secretions: A comparison between successful and unsuccessful in vitro fertilization cycles

Cited by 27 publications

References 44 publications

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract

Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes

İntrasitoplazmik sperm enjeksiyonu (ICSI) uygulanan infertil kadınlarda gebelik başarısını etkileyen faktörlerin değerlendirilmesi

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