Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome

Mancuso, Michelangelo; Bonanni, Enrica; LoGerfo, Annalisa; Orsucci, Daniele; Maestri, Michelangelo; Chico, Lucia; DiCoscio, Elisa; Fabbrini, Monica; Siciliano, Gabriele; Murri, Luigi

doi:10.1016/j.sleep.2011.10.030

Cited by 69 publications

(47 citation statements)

References 13 publications

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“…Other studies found that the severity of OSA was negatively correlated with total antioxidant capacity (TAC) [15] and positively correlated with urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) excretion [16]. Oxidative stress markers such as TAC (defined as ferric reducing antioxidant power) were found to be useful in detecting and monitoring redox imbalance and the CPAP therapy effect in OSA patients without stroke [15]. The 8-OHdG is a modified deoxyribonucleic acid (DNA) base that has been used for evaluation of oxidative DNA damage [17].…”

Section: Introductionmentioning

confidence: 99%

Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

Chen

et al. 2015

Sleep Medicine

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Section: Introductionmentioning

confidence: 99%

Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

Chen

et al. 2015

Sleep Medicine

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“…Most studies have found an elevated blood 8-isoprostane level in OSA subjects compared to non-OSA controls [39,40], and a randomized controlled study showed that levels were subsequently decreased after CPAP therapy for 3 months [41]. Similarly, AOPP levels were higher in untreated OSA subjects [17]. We found that elevated levels of 8-isoprostane correlated with OSA severity independent of age and BMI, and that AOPP also showed a similar correlation, but that the association became non-significant on adjustment for age and BMI.…”

Section: Discussionmentioning

confidence: 99%

“…Monocyte chemo-attractant protein-1 (MCP-1), a relatively novel biomarker mediating monocyte infiltration in atherosclerotic plaque, was found to be overly expressed in patients with severe OSA in a recent study [16]. Advanced oxidation protein products (AOPP) and 8-isoprostane, both biomarkers of oxidative stress, are being increasingly explored in various cardiometabolic disorders, including OSA [17,18]. …”

Section: Introductionmentioning

confidence: 99%

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

et al. 2016

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Background: Endothelial dysfunction has been recognized to occur in the context of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious effect on vascular function with concurrence of both conditions is largely unknown. Objective: To investigate whether the concurrence of OSA and smoking poses an additive detriment to endothelial dysfunction. Methods: Chinese men without a history of chronic medical illness were invited to complete a questionnaire including smoking pack-year exposure, polysomnography and peripheral arterial tonometry (PAT) for endothelial function. Serum 8-isoprostane, advanced oxidation protein products (AOPP) and monocyte chemo-attractant protein-1 (MCP-1) were measured. Results: 114 men were successfully enrolled. PAT ratio, adjusted for age and body mass index, correlated inversely with overall severity of OSA: apnea-hypopnea index (AHI), r = -0.160 (p = 0.092); oxygen desaturation index, r = -0.214 (p = 0.024); duration of oxygen saturation <90%, r = -0.219 (p = 0.020); and minimum oxygen saturation, r = 0.250 (p = 0.008). The PAT ratio decreased with increasing pack-year group (p = 0.018). It was lower with concurrent smoking history and moderate-severe OSA (AHI ≥15/h) compared to having one or neither factor (p = 0.011). Serum levels of 8-isoprostane and AOPP were positively related to severity of OSA, while MCP-1 correlated with smoking quantity. Multiple linear regression analyses showed that severity of intermittent hypoxia, MCP-1 and pack-year exposure were independent predictors of PAT ratio. Conclusion: While OSA, in particular intermittent hypoxemia, and tobacco smoking were independent risk factors, the concurrence of moderate-severe OSA and smoking was associated with the most severe impairment in endothelial function.

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“…The continued hypoxia-reoxygenation episodes have a pivotal role in the pathogenesis of the endothelial dysfunction in OSAS: the intermittent hypoxia may induce the production of reactive oxygen species (ROS) that contribute to the generation of adhesion molecules, leukocyte activation, and an enhanced systemic inflammation leading to endothelial damage [21]. In OSAS an increase in lipid and protein oxidation [3,7,9,13,18,26] and a decrease in antioxidant defenses [7,9,16,23,27,30] have been demonstrated. In OSAS subjects the hypoxia-reoxygenation phenomena influence nitric oxide (NO) synthesis by NO synthase (NOS) inducing a down-regulation of the eNOs expression [32,33] and activation [15] and a simultaneous increase in inducible NOS (iNOS) expression [15].…”

Section: Introductionmentioning

confidence: 99%

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

Caimi

Presti

Montana

et al. 2016

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Abstract. It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index -AHI-(Low = 21 subjects with AHI <30 and High = 27 subjects with AHI >30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the whole group of OSAS subjects. In the entire group of OSAS subjects the TBARS/NOx ratio results positively correlated with AHI and ODI and inversely correlated with mSO 2 .

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Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome

Cited by 69 publications

References 13 publications

Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome

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