Oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria

Yeldu, Mohammed Haruna; Ibrahim, Yakubu; Akuyam, SA; Danasabe, Isah Muhammad; Shehu, Buhari; Danjuma, Mohammed; Bello, Miftahu; Usman, Yahaya

doi:10.3126/ajms.v10i6.25593

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…In a recent study it was observed that in patients of pulmonary tuberculosis the levels of anti oxidants decrease and that of oxidative stress biomarkers remarkably increase as in Nigerian population 25 .…”

Section: Discussionmentioning

confidence: 99%

A study on role of oxidative stress and nutrients in patients with pulmonary tuberculosis in a tertiary health care hospital

Aggarwal¹,

Batra²

2023

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Background: The association between TB, oxidative stress and dietary supplements is multidirectional. The inflammation associated pathology in tuberculosis leads to the development of the free radical generation. Methods: A cross-sectional study design was selected for the study. This study was carried out in the Department of Biochemistry, Santosh Medical College, Ghaziabad. A total of 75 subjects will be enrolled from department of respiratory medicine from Santosh hospital, Ghaziabad and were divided into 3 groups as 75 healthy individuals of either sex as controls, 75 newly diagnosed patients of pulmonary tuberculosis and 75 patients after 6 months from starting treatment. Patients with newly diagnosed tuberculosis and on anti tubercular treatment (after 6 months) belonging to age group of 18 years and above from either sex were included in this study. The data was collected from July 2020–June 2021. Results: A total of 225 patients were recruited for the study from the department of respiratory medicine. Newly diagnosed cases have significantly increased levels of MDA with values estimated as 4.59 nmol/ml as compared to the healthy subjects with value as 1.82 nmol/ml. Anti oxidant markers i.e. Serum calcium, total antioxidant capacity, Vitamin D and zinc levels were decreased with the TB patients and were raised after 6 months of ATT. Conclusion: Tuberculosis is an important health problem requiring early diagnosis for timely initiation of the therapy and control of disease transmission (RNTCP Guideline 2010). Although the available data suggest that the TB epidemic may be on the decline, the absolute number of new cases is still the highest. Anti tubercular therapy proves to be beneficial in reducing the oxidative stress and hence, the tubercular burden.

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Section: Discussionmentioning

confidence: 99%

A study on role of oxidative stress and nutrients in patients with pulmonary tuberculosis in a tertiary health care hospital

Aggarwal¹,

Batra²

2023

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“…However, in different pathological conditions, including inflammatory diseases, an imbalance between oxidation processes and antioxidant protection develops and results in oxidative stress 25 . High levels of free radicals cause damage to all cellular components, including modifications of proteins 27,28 .…”

Section: Main Group (N=24)mentioning

confidence: 99%

“…The reasons for these changes are debatable and require further studies. However, there are data that pulmonary TB and HIV/TB coinfection, as well as HIV-infection, are accompanied by increased oxidative stress biomarkers and decreased total antioxidant status, due to chronic inflammation and hypoxia [28][29][30] .…”

Section: Main Group (N=24)mentioning

confidence: 99%

Morphological changes of the small intestine mucosa in HIV/Mycobacterium tuberculosis coinfection

Тодоріко¹,

Pidverbetska²,

Шевченко³

et al. 2021

Arch Balk Med Union

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Les changements morphologiques de la membrane muqueuse de l'intestin grêle dans la co-infection VIH/Mycobacterium tuberculosisIntroduction. A ce moment, il n'y a pratiquement pas de données sur les modifications pathomorphologiques de la muqueuse de l'intestin grêle lors de la co-infection VIH/tuberculose, ce qui pourrait être à la base du développement d'une malabsorption. Le but de l'étude est d'étudier les caractéristiques de la structure morphologique de l'intestin grêle dans la tuberculose associée au VIH. Matériaux et méthodes. L'étude prospective pathomorphologique a inclus 24 patients avec co-infection VIH/Mycobacterium tuberculosis (groupe principal) et 20 personnes sans infection par le VIH, de pathologie gastro-intestinale ou de signes morphologiques de tuberculose (groupe témoin). Résultats. L'épaisseur de la petite muqueuse intestinale, la hauteur et la largeur moyennes des villosités

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Free radical reactions in socially significant infectious diseases: HIV infection, hepatitis, tuberculosis

et al. 2020

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The analysis of current literature data on the study of the features of the course of free-radical reactions, as well as the state of the antioxidant defense system at socially significant infectious diseases HIV infection, hepatitis, tuberculosis was carried out. The role of this kind of reaction in the genesis and progression of socially significant infections a long time has been studied. Foreign studies of recent years have been focused on the identification of specific markers of oxidative and carbonyl stress, which make it possible to identify the redox imbalance of the cell under conditions of infection and target affect it to modulate the activity of the main transcription factors of viral proteins and the bacteria pathogenicity. Numerous sources indicate the involvement of active oxygen metabolites in a wide range of events in infected cells and tissues, including neoplastic transformation processes. These biochemical markers can be used as additional criteria for monitoring the progression of infection. At the same time, noticeable gaps in this area there are that may become the goal of future research. The issues of changing free radical reactions depending on gender, age, place of residence of patients remain practically unstudied. There is little data about intensity of oxidative stress in patients of reproductive age with HIV, hepatitis B and C, and pulmonary tuberculosis, as well as the relationship of antioxidant deficiency with reproductive disorders in conditions of infection. These data could serve as the basis for the development of pathogenetically substantiated methods for the correction of socially significant infectious diseases. Modulation of the production of reactive oxygen metabolites and oxidative stress is a potentially new pharmacological approach to reduce the effects of viral and bacterial exposure.

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Oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria

Cited by 3 publications

References 9 publications

A study on role of oxidative stress and nutrients in patients with pulmonary tuberculosis in a tertiary health care hospital

A study on role of oxidative stress and nutrients in patients with pulmonary tuberculosis in a tertiary health care hospital

Morphological changes of the small intestine mucosa in HIV/Mycobacterium tuberculosis coinfection

Free radical reactions in socially significant infectious diseases: HIV infection, hepatitis, tuberculosis

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