Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves

Cuervo, Wilmer; Sordillo, Lorraine M.; Abuelo, Ãngel

doi:10.3390/antiox10020255

Cited by 23 publications

(15 citation statements)

References 70 publications

(83 reference statements)

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“…Excessive accumulation of prooxidant substances, such as ROS, can cause oxidative stress in ruminants [ 93 , 94 ]. Some antioxidant enzymes, such as GPx, SOD and CAT are important because they can convert ROS into less harmful compounds for the organism [ 56 ], and consequently can reduce ROS-mediated damage on biological macromolecules [ 95 , 96 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the present meta-analysis, dietary supplementation with TANs increased the activity of antioxidant enzymes (CAT and GPx) and reduced the concentration of malondialdehyde in sheep blood serum. This suggests that inclusion of TANs in the diet could be used as a dietary strategy to mitigate oxidative stress in sheep, which could improve animal health [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

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Growth Performance, Meat Quality and Antioxidant Status of Sheep Supplemented with Tannins: A Meta-Analysis

Orzuna-Orzuna

Dorantes-Iturbide

Bueno

et al. 2021

Animals

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The objective of this study was to evaluate the effects of dietary supplementation with tannins (TANs) on productive performance, carcass characteristics, meat quality, oxidative stability, and blood serum antioxidant capacity of sheep through a meta-analysis. Using Scopus, Web of Science, ScienceDirect, and PubMed databases, a systematic search was performed for studies published in scientific journals that investigated the effects of TANs supplementation on the variables of interest. Only studies with weaned or older sheep were included. The data analyzed were extracted from 53 peer-reviewed publications. The sheep included in the present study were between 2 and 6 months old, and between 12 and 31 kg of body weight. The effects of TANs were analyzed using random-effects statistical models to examine the standardized mean difference (SMD) between treatments with TANs and control (no TANs). Heterogeneity was explored by meta-regression and a subgroup analysis was performed for covariates that were significant. Supplementation with TANs did not affect dry matter intake, pH, color (L* and b*), Warner–Bratzler shear force, cooking loss and meat chemical composition (p > 0.05). Supplementation with TANs increased daily weight gain (SMD = 0.274, p < 0.05), total antioxidant capacity (SMD = 1.120, p < 0.001), glutathione peroxidase enzyme activity (SMD = 0.801, p < 0.001) and catalase (SMD = 0.848, p < 0.001), and decreased malondialdehyde (MDA) concentration in blood serum (SMD = −0.535, p < 0.05). Supplementation with TANs decreased feed conversion rate (SMD = −0.246, p < 0.05), and the concentration of MDA (SMD = −2.020, p < 0.001) and metmyoglobin (SMD = −0.482, p < 0.05) in meat. However, meat redness (SMD = 0.365), hot carcass yield (SMD = 0.234), cold carcass yield (SMD = 0.510), backfat thickness (SMD = 0.565) and the Longissimus dorsi muscle area (SMD = 0.413) increased in response to TANs supplementation (p < 0.05). In conclusion, the addition of tannins in sheep diets improves productive performance, antioxidant status in blood serum, oxidative stability of meat and some other characteristics related to meat and carcass quality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Growth Performance, Meat Quality and Antioxidant Status of Sheep Supplemented with Tannins: A Meta-Analysis

Orzuna-Orzuna

Dorantes-Iturbide

Bueno

et al. 2021

Animals

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“…Newborn calves have been reported to experience oxidative stress throughout the first month of life [ 10 , 11 ], which has been documented to negatively affect the responsiveness of their immune system [ 12 , 22 ]. This study aimed to investigate to which extent supplementing antioxidants to newborn calves using commercially available micronutrient parenteral supplements improves their redox status and immune response to intranasal vaccination.…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, the immune response elicited by vaccination in newborn calves is lower than in adult cattle [ 5 ]. Newborn calves experience oxidative stress throughout the first months of life [ 9 , 10 , 11 ], which reduces immune cell functions relevant to vaccination responsiveness [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Parenteral Antioxidant Supplementation at Birth Improves the Response to Intranasal Vaccination in Newborn Dairy Calves

Nayak

Abuelo

2021

Antioxidants

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Newborn calves experience oxidative stress throughout the first month of their life, which is known to decrease lymphocyte functions relevant to vaccine responsiveness. Thus, this study aimed to determine the extent to which parenteral antioxidant supplementation given at birth improves the response to an intranasal viral vaccine in the first month of life of newborn dairy calves. For this, 21 calves were randomly assigned at birth to one of two commercially available antioxidant micronutrient supplements or a placebo group receiving 0.9% sterile saline (n = 7/group). Serum and nasal secretion samples were collected before administration of treatments and an intranasal vaccine against respiratory viruses (bovine herpesvirus type 1, bovine syncytial respiratory virus, and parainfluenza 3), and once weekly for the first four weeks of age. Systemic redox balance was determined in serum. Immunoglobulin A specific for bovine herpesvirus 1 and bovine syncytial respiratory virus was quantified in nasal secretions as a proxy to intranasal vaccine responsiveness. Our results showed that parenteral administration of antioxidants at birth improved calves’ redox balance. Additionally, calves receiving antioxidant supplementation had higher concentrations of immunoglobulin A in their nasal secretions than calves in the control group. Thus, we conclude that supplementation of calves with antioxidants at birth could be a practical strategy to improve intranasal vaccine response. Future larger studies should evaluate the extent to which this increased mucosal response to intranasal vaccination could result in decreased calf morbidity and mortality.

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“…Accumulated evidence supports the idea that stress leads to an increase of pro-in ammatory cytokines (N. Li et al, 2016; S. Li et al, 2020). However, the data from animal models and clinical research revealed signi cant variabilities in type I and type II cytokine pro les (Cuervo, Sordillo, & Abuelo, 2021;Koivisto et al, 2019;Razali et al, 2020). It seems to be clear that the examination of a single cytokine, or small groups of cytokines are not su cient to evaluate the alterations of cytokines in depression-related animal models.…”

Section: Effects Of Nai Exposure On Cytokine Levels Of Cms-treated Micementioning

confidence: 93%

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

Hu¹,

Niu²,

Xu³

et al. 2021

Preprint

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The presence of negative air ions (NAI) is suggested to be a good factor in improving psychological status and used in treating depression as an alternative approach. However, the biological explanation for effects of NAI on alleviating depression symptoms has less been explored. In this study, the chronic mild stress (CMS) protocol was used to induce transcriptional depressive-like behaviors in mice, and the effects of NAI exposure on CMS-induced depression-like behaviors were examined. Thirty-day NAI exposure prevented the CMS-induced depression-like behaviors as shown by the restoration of sucrose preference and reduced immobility time in the suspension test. In addition, the elevation of serous corticosterone was present in CMS-treated mice but not existed in those with the NAI exposure. Furthermore, we observed a shifted balance between the cytokines secreted by type 1 T helper (Th1) cells and type 2 T helper (Th2) cells. In conclusion, NAI intervention is able to ameliorate CMS-induced depression-like behaviors in mice, and this effect is associated with the alteration of corticosterone and functional rebalance between Th1 and Th2 cells.

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Oxidative Stress Compromises Lymphocyte Function in Neonatal Dairy Calves

Cited by 23 publications

References 70 publications

Growth Performance, Meat Quality and Antioxidant Status of Sheep Supplemented with Tannins: A Meta-Analysis

Growth Performance, Meat Quality and Antioxidant Status of Sheep Supplemented with Tannins: A Meta-Analysis

Parenteral Antioxidant Supplementation at Birth Improves the Response to Intranasal Vaccination in Newborn Dairy Calves

Negative air ion exposure ameliorates depression-like behaviors induced by chronic mild stress in mice

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