Oxidative stress decreases the redox ratio and folate content in the gut microbe, Enterococcus durans (MTCC 3031)

Jose, Steffi; Bhalla, Prerna; Suraishkumar, G. K.

doi:10.1038/s41598-018-30691-4

Cited by 23 publications

(14 citation statements)

References 32 publications

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“…Indeed, B9 is important for the gut immune system as it is necessary for T reg cell survival and mice fed a vitamin B9-deficient diet showed increased susceptibility to intestinal inflammation. [94,95] On the other hand, oxidative stress in the gut may lower the bacterial folate production as demonstrated in the model gut bacterium Enterococcus durans, [96] which may impact the host. However, there is some controversy for dietary folate supplementation in disease as both folate deficiency as high dose supplementation of the synthetic dietary form of FA have been associated with colon cancer.…”

Section: Vitamin B9-folatementioning

confidence: 99%

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

Kundra¹,

Rachmühl²,

Lacroix³

et al. 2021

Molecular Nutrition Food Res

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In patients with inflammatory bowel diseases (IBD), dietary micronutrient intake is low and deficiencies are common. Besides the host, also the gut microbiota require micronutrients and low levels may disturb its functioning. Multi‐omics studies indeed detected shifts in micronutrient‐dependent microbial pathways in IBD. It is however not clear whether micronutrients may alleviate inflammation directly, by modulating the immune system, or also indirectly, by modulating the structure and function of the gut microbiota. The latter seems of particular interest, since the gut microbiota is one of the future therapeutic targets in IBD. A review of the most recent available literature on relevant micronutrients in context of IBD and gut microbiota was conducted. An overview per relevant micronutrient on its role on gut bacterial growth, metabolism and host–microbe interactions during gut inflammation is provided. Dietary micronutrients have potential to be part of future personalized microbiome‐targeted therapies in IBD, considering both the micronutrient status of the host and the gut microbiota. However, cohort studies together with integrated multi‐scale studies are needed to understand the mechanisms of micronutrient–microbiome–host interactions in IBD and to evaluate efficacy and safety of dietary micronutrient treatment strategies.

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Section: Vitamin B9-folatementioning

confidence: 99%

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

Kundra¹,

Rachmühl²,

Lacroix³

et al. 2021

Molecular Nutrition Food Res

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“…It is clear, therefore, that MS is a multi-factorial pathology and genetic, environmental, and immunological factors are included in its etiology. Multiple sclerosis appears particularly in young women (female:male ratio = 3:1), especially in those women who have suffered intestinal disorders since birth (Jose et al, 2018;Sauma and Casaccia, 2020). It has been recently shown that an alteration of the intestinal microbiota leads to over-stimulation of immune cells with a higher incidence of the development of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and MS (Brown et al, 2019).…”

Section: Autoimmunity and Multiple Sclerosismentioning

confidence: 99%

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

et al. 2021

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Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called “microbiota.” Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota–brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?

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“…Lactobacillus plantarum YW11 [ 135 ], Lactobacillus plantarum CCFM10 [ 136 ], and Enterococcus durans MTCC 3031 [ 137 ] were found to restore microbial integrity in aging murine models through normalization of the redox ratio. On the other hand, gut metabolism in mice could be disrupted following administration of antibiotics, which was characterized by a shift of the redox potential after just 24 h [ 138 ].…”

Section: Is There a Relationship Between Oxidative Stress And Gut mentioning

confidence: 99%

Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects

et al. 2020

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Vitamin B3, or niacin, is one of the most important compounds of the B-vitamin complex. Recent reports have demonstrated the involvement of vitamin B3 in a number of pivotal functions which ensure that homeostasis is maintained. In addition, the intriguing nature of its synthesis and the underlying mechanism of action of vitamin B3 have encouraged further studies aimed at deepening our understanding of the close link between the exogenous supply of B3 and how it activates dependent enzymes. This crucial role can be attributed to the gut microflora and its ability to shape human behavior and development by mediating the bioavailability of metabolites. Recent studies have indicated a possible interconnection between the novel coronavirus and commensal bacteria. As such, we have attempted to explain how the gastrointestinal deficiencies displayed by SARS-CoV-2-infected patients arise. It seems that the stimulation of a proinflammatory cascade and the production of large amounts of reactive oxygen species culminates in the subsequent loss of host eubiosis. Studies of the relationhip between ROS, SARS-CoV-2, and gut flora are sparse in the current literature. As an integrated component, oxidative stress (OS) has been found to negatively influence host eubiosis, in vitro fertilization outcomes, and oocyte quality, but to act as a sentinel against infections. In conclusion, research suggests that in the future, a healthy diet may be considered a reliable tool for maintaining and optimizing our key internal parameters.

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Oxidative stress decreases the redox ratio and folate content in the gut microbe, Enterococcus durans (MTCC 3031)

Cited by 23 publications

References 32 publications

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

Role of Dietary Micronutrients on Gut Microbial Dysbiosis and Modulation in Inflammatory Bowel Disease

The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

Minireview Exploring the Biological Cycle of Vitamin B3 and Its Influence on Oxidative Stress: Further Molecular and Clinical Aspects

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