Oxidative stress during early pregnancy and birth outcomes

Shastri, Lisha; Pammal, Rajkumar S; Mani, Indu; Thomas, Tinku; Kurpad, Anura V

doi:10.1017/s1368980016001191

Cited by 23 publications

(12 citation statements)

References 23 publications

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“…Further, routine supplementation of Fe to these high Hb women for the duration of gestation resulted in persistent lower PON-1 activity in cord blood and lighter birth weights. Although these results were not measured in placental tissue, our correlations of Fe with birth weight, after covariate adjustments, is very similar to the relationship with birth weight reported by Shastri et al (2016), which may be related to over exposure to iron and subsequent increase in oxidative stress. Cadmium and lead reduce total antioxidant potential by depleting glutathione and protein-bound sulfhydryl groups that serve to neutralize free radicles (Stohs and Bagchi 1995).…”

Section: Discussionsupporting

confidence: 82%

“…The toxicity of iron-catalyzed reactive oxygen species (ROS) is well established. Shastri et al (2016) measured hemoglobin (Hb) in the first trimester of pregnancy and grouped women with high Hb levels (≥120 g/l) and compared them to women with normal to low Hb levels (< 110 g/l). Both groups continued to take an iron supplement for the duration of the pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Placental concentrations of essential, toxic, and understudied metals and relationships with birth outcomes in Chattanooga, TN

Mikelson

Troisi

Lalonde

et al. 2019

Environmental Research

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Background: Comprehensive examinations of placental metal concentrations and correlations with infant parameters are under-investigated. Chattanooga, Tennessee’s consistently high incidence of low birth weight and potential for metal exposure provides an ideal opportunity to investigate potential correlations. Objectives: To investigate the associations between a wide variety of metals in placental tissue and multiple infant parameters. Methods: A total of 31 elements were screened via ICP-MS in 374 individual placental samples. Of those, 14 were quantifiable in >86% of the samples. We examined correlations between metal concentrations and infant parameters (birth weight, gestational age, birth weight centile, placental weight, birth length and head circumference). We fit multivariable regression models to estimate the covariate-adjusted associations of birth weight with ln-transformed concentrations of each of the 14 metals and used generalized additive models to examine nonlinear relationships. Results: Some of the strongest relationships with infant parameters came from several lesser-studied metals. Placental rhodium concentrations were negatively correlated with almost all infant parameters. In the fully adjusted regression model, birth weight was significantly associated with several metals. On an IQR (25th to the 75th percentile) basis, estimated changes in birthweight were: for cobalt (82.5 g, IQR=6.05 µg/kg, p = 0.006), iron (−51.5 g, IQR=171800 µg/kg, p = 0.030), manganese (−27.2 g, IQR=152.1 µg/kg, p = 0.017), lead (−72.7 g, IQR=16.55 µg/kg, p = 0.004) and rhodium (−1365.5 g, IQR=0.33 µg/kg, p < 0.001). Finally, a generalized additive model showed significant nonlinear relationships between birth weight and concentrations of Co and Rh. Conclusions: Our comprehensive examination of placental metals illustrate many strong associations between lesser-studied metals and infant parameters. These data, in combination with our correlations of well-studied metals, illustrate a need to consider in utero exposure to a broad array of metals when considering fetal development.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Placental concentrations of essential, toxic, and understudied metals and relationships with birth outcomes in Chattanooga, TN

Mikelson

Troisi

Lalonde

et al. 2019

Environmental Research

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“…Also, Elmas et al (25) found blood pressure and serum levels of UA, xanthine oxidase activity (XOA) and allantoin levels were higher in PE patients when compared with pregnant controls and Shastri et al (26) reported significantly higher lipid peroxides and lower paraoxonase-1 activity during 1 st trimester in pregnant women with high hemoglobin than women with low/normal hemoglobin concentration. The obtained data go in hand with Pourghassem Gargari et al (27) who detected significantly higher serum levels of MDA and significantly lower TAC in women with PE compared to controls.…”

Section: Discussion:-mentioning

confidence: 99%

Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

MD¹,

MD²,

MD³

2018

IJAR

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Objectives: To evaluate changes in oxidant milieu in normotensive pregnant women (No PE) and those who developed pre-eclampsia (PE) and to define a relation between these changes and PE development. Patients & Methods: All pregnant women gave three blood samples at 12 th week (S1) gestational age, start of 3 rd trimester (S2) and 48-hr postpartum (S3) for spectrophotometeric estimation of serum levels of malondialdehyde (MDA) and uric acid (UA), and activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and catalase activity. Control group included a similar number of non-pregnant women. Blood pressures were estimated at 1 st visit and monthly for diagnosis of PE. Results: 65 pregnant women developed PE; 54 had mild and 11 had severe PE; while 19 women developed early and 46 late PE. Sample S1 levels showed non-significant differences between all study participants. S2 serum MDA levels were significantly higher in pregnant women than their S1 and control levels and in PE versus No PE women. S2 serum UA levels were significantly higher in PE women than their S1, control and corresponding levels in No PE women. S2 serum SOD and GPx activity was significantly lower in PE women than their S1, control and corresponding measures in No PE women. Serum GR and catalase activities were significantly lower in S2 samples of pregnant women than their S1 and control activities with significantly lower activity in No PE women. S3 serum levels of MDA and UA were decreased and activities of antioxidant enzymes were adjusted in S3 sample than in S2 sample, but with significant difference between PE and No PE women. Statistical analysis defined serum MDA at ≥13.2±0.128 µmole/L and GPx activity at ≥450 U/L as risk cutoff point for PE development. Conclusion: Pregnancy is stressful condition associated with activation of oxidative stress (OS) and overproduction of oxidative products and disturbed activity of antioxidant enzymes. Exaggerated OS compromises placental functions and induces development of hypertensive manifestations. Elevated serum MDA and GPx enzyme

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“…With respect to oxidative status during pregnancy with or without any supplementation, very few studies addressed its own potential variation throughout normal gestation. The evaluation is usually carried out either early [26] or at any gestational age [9] [11] [27] [28]. Based on considerations put forth by Liochev &.…”

Section: Discussionmentioning

confidence: 99%

Routine Iron Supplementation during Pregnancy: Its Reflection on Iron and Oxidative Status in a Cohort of Pregnant Women in Kinshasa, DR Congo

Mbangama¹,

Tandu-Umba²,

Mbungu³

2019

OJOG

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Background: Due to maternal and fetal physiologic demand, the rate along with amplitude of anemia is expected to rise over pregnancy. The iron and oxidative status also are expected to vary accordingly. It is thus assumed that iron supplementation will somewhat modify the profile observed in markers of iron and oxidative status of our series. Objectives: We aimed to measure variations of indices of iron and oxidative status of iron supplemented women over pregnancy. Methods: This is a prospective observational cohort of 74 pregnant women with singleton pregnancy whose baseline iron and oxidative status have been recently assessed at University Clinics of Kinshasa, DR Congo. Women with anemia (Hb < 10 g%) took iron for curative purposes (320 mg/day of ferric ammonium citrate) while the others received preventive iron supplementation (160 mg/day). Iron was associated with 15 mg folate/day. Nutritional iron intake was measured through a 24-hour recall using a questionnaire of common foods, including stuffs and habits likely to impede iron absorption. Biological parameters of iron and oxidative status included hemoglobin, hematocrit, ferritin, serum iron, transferrin, superoxide dismutase or SOD, uric acid, oxidized LDL and blood glucose. For statistical calculations we used t-test, chi-square test, ANOVAR and regression, the significance being stated at p < 0.05. Results: Trimester wise evolution of hematologic status in anemic women shows a rise in values of hemoglobin (+average 1 gr/dl) and hematocrit (+3%) throughout pregnancy, with significant change only between recruitment and 28-32 weeks. In non anemic women a significant decrease was observed, although levels remained normal. For ferritin (7.5-53 ng/mL from recruitment to term) and transferrin (107-157 g/L), significant rise was found in anemic women from recruitment to 28-32 weeks, while in

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Oxidative stress during early pregnancy and birth outcomes

Cited by 23 publications

References 23 publications

Placental concentrations of essential, toxic, and understudied metals and relationships with birth outcomes in Chattanooga, TN

Placental concentrations of essential, toxic, and understudied metals and relationships with birth outcomes in Chattanooga, TN

Maternal Oxidant-Antioxidant Homeostasis During Normotensive and Preeclamptic Pregnancy.

Routine Iron Supplementation during Pregnancy: Its Reflection on Iron and Oxidative Status in a Cohort of Pregnant Women in Kinshasa, DR Congo

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