Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease

Gargouri, Bilel; Mseddi, Malek; Mnif, F.; Abid, M.; Attia, Hamadi; Lassoued, Saloua

doi:10.1002/jcla.23051

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…in gd patients this phenomenon had a positive correlation with FT3 levels. 86 gargouri et al 87 also demonstrated a positive correlation between T3 levels and the immunoreactivity towards Mdamodified catalase in GD patients vs. controls. in a study by choi et al, 88 Mda and 8-hydroxy-2'deoxyquanosine (8-oHdg), H 2 o 2 and intracellular superoxide anion levels were measured in the tear fluid of GD patients.…”

Section: Autoimmunity Cancer and Oxidative Stressmentioning

confidence: 88%

Oxidative stress as a key feature of autoimmune thyroiditis: an update

et al. 2021

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iNTrodUcTioN: oxidative stress has been proposed as one of the factors concurring in the pathophysiology of autoimmune thyroid diseases. reactive oxygen species are the main expression of oxidative stress in biological systems, and their production can overcome antioxidant defenses ultimately leading to cell damage, apoptosis, and death. The present review was aimed at describing the state of the art of the relationships between oxidative stress and autoimmune thyroiditis. The most used biomarkers of oxidative stress and their correlation with thyroid function are reported. eVideNce acQUiSiTioN: We conducted a search of the literature in the english language starting from 2000, using the following search terms: "Hashimoto thyroiditis," "autoimmune thyroiditis," "hypothyroidism," "hyperthyroidism," "oxidative stress," "oxidants," "antioxidant," "advanced glycation end products." Both clinical studies and animal models were evaluated. eVideNce SYNTHeSiS: data form clinical studies clearly indicate that the balance between oxidants and antioxidants is shifted towards the oxidative side in patients with autoimmune thyroiditis, suggesting that oxidative stress may be a key event in the pathophysiology of the disease, irrespective of thyroid function. Studies in animal models, such as the NOD.H2h4 mouse, confirm that thyroidal accumulation of ROS plays a role in the initiation and progression of autoimmune thyroiditis. coNclUSioNS: oxidant/antioxidant imbalance represent a key feature of thyroid autoimmunity. oxidative stress parameters could be used as biochemical markers of chronic inflammation, to better predict the disease evolution along its natural history. dietary habits and antioxidant supplements may provide protection from autoimmunity, opening new perspectives in the development of more tailored therapies.

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Section: Autoimmunity Cancer and Oxidative Stressmentioning

confidence: 88%

Oxidative stress as a key feature of autoimmune thyroiditis: an update

et al. 2021

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“…Thus, altered molecules, with sufficient homology to the native protein antigens, can result in the production of specific autoantibodies and lead to the development of AD[41, 42,44,[54][55][56][57][58][59][60][61][62][63][64]. Systemic autoimmune rheumatic diseases (SARDs) are an important group of ADs.…”

Section: Introductionmentioning

confidence: 99%

Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies

et al. 2021

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IntroductionOxidative stress is one of many factors suspected to promote antinuclear autoantibody (ANA) formation. Reactive oxygen species can induce changes in the antigenic structure of macromolecules, causing the immune system to treat them as “neo-antigens” and start production of autoantibodies. This study was designed to evaluate the relationship between oxidative stress markers, lifestyle factors and the detection of ANA.Material and methodsWe examined measures of oxidative stress indices of free-radical damage to lipids and proteins, such as total oxidant status (TOS), concentration of protein thiol groups (PSH), and malondialdehyde (MDA), activity of superoxide dismutase (SOD) in in 1731 serum samples. The parameters of the non-enzymatic antioxidant system, such as total antioxidant status (TAS) and uric acid concentration (UA), were also measured and the oxidative stress index (OSI -index) was calculated. All samples were tested for the presence of ANA using an indirect immunofluorescence assay (IIFA).ResultsThe presence of ANA in women was associated with lower physical activity (p=0.036), less frequent smoking (p=0.007) and drinking of alcohol (p=0.024) accompanied by significant changes in SOD isoenzymes activity (p<0.001) and a higher uric acid (UA) concentration (p<0.001). In ANA positive males we observed lower concentrations of PSH (p=0.046) and increased concentrations of MDA (p=0.047).ConclusionsThe results indicate that local oxidative stress may be associated with increased probability of ANA formation in a sex-specific manner.

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“…Oxygen has a deleterious effect on biomolecules in the form of free radical and reactive oxygen species (ROS) [ 105 ], and many viruses have been demonstrated to cause cell damage by generating ROS and changing redox homeostasis [ 106 , 107 , 108 , 109 ]. The body can defend itself against ROS by using enzymes such as SOD, CAT, and GSH-Px [ 110 , 111 , 112 ]. MDA is the principal product of polyunsaturated fatty acid peroxidation, which is considered a highly toxic molecule and a marker of lipid peroxidation [ 113 ].…”

Section: Discussionmentioning

confidence: 99%

Recombinant Muscovy Duck Parvovirus Led to Ileac Damage in Muscovy Ducklings

Zhang

et al. 2022

Viruses

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Waterfowl parvovirus (WPFs) has multiple effects on the intestinal tract, but the effects of recombinant Muscovy duck parvovirus (rMDPV) have not been elucidated. In this study, 48 one-day-old Muscovy ducklings were divided into an infected group and a control group. Plasma and ileal samples were collected from both groups at 2, 4, 6, and 8 days post-infection (dpi), both six ducklings at a time. Next, we analyzed the genomic sequence of the rMDPV strain. Results showed that the ileal villus structure was destroyed seriously at 4, 6, 8 dpi, and the expression of ZO-1, Occludin, and Claudin-1 decreased at 4, 6 dpi; 4, 6, 8 dpi; and 2, 6 dpi, respectively. Intestinal cytokines IFN-α, IL-1β and IL-6 increased at 6 dpi; 8 dpi; and 6, 8 dpi, respectively, whereas IL-2 decreased at 6, 8 dpi. The diversity of ileal flora increased significantly at 4 dpi and decreased at 8 dpi. The bacteria Ochrobactrum and Enterococcus increased and decreased at 4, 8 dpi; 2, 4 dpi, respectively. Plasma MDA increased at 2 dpi, SOD, CAT, and T-AOC decreased at 2, 4, 8 dpi; 4, 8 dpi; and 4, 6, 8 dpi, respectively. These results suggest that rMDPV infection led to early intestinal barrier dysfunction, inflammation, ileac microbiota disruption, and oxidative stress.

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Oxidative stress enhances the immune response to oxidatively modified catalase enzyme in patients with Graves’ disease

Cited by 9 publications

References 29 publications

Oxidative stress as a key feature of autoimmune thyroiditis: an update

Oxidative stress as a key feature of autoimmune thyroiditis: an update

Serum antinuclear autoantibodies are associated with measures of oxidative stress and lifestyle factors: analysis of LIPIDOGRAM2015 and LIPIDOGEN2015 studies

Recombinant Muscovy Duck Parvovirus Led to Ileac Damage in Muscovy Ducklings

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