Oxidative Stress, Genomic Integrity, and Liver Diseases

Sadasivam, Nanthini; Kim, Yu-Ji; Radhakrishnan, Kamalakannan; Kim, Don-Kyu

doi:10.3390/molecules27103159

Cited by 56 publications

(31 citation statements)

References 189 publications

(178 reference statements)

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“…Furthermore, an increase in proinflammatory cascade can provoke ROS generation via CYP2E1 and NADH-dependent cytochrome reductase, NADPH oxidases, endoplasmic reticulum (ER) stress response, and mitochondrial dysfunction. These cellular responses may exacerbate hepatocellular damage and subsequent release of damage-associated molecular patterns (DAMPs), further exacerbating immune cell stimulation and thus developing fibrosis/cirrhosis and cancer [ 26 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Pathophysiology Of Aldmentioning

confidence: 99%

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives

Jeong

Kim

2022

Biomedicines

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Alcohol-related liver disease (ALD) refers to a spectrum of liver manifestations ranging from fatty liver diseases, steatohepatitis, and fibrosis/cirrhosis with chronic inflammation primarily due to excessive alcohol use. Currently, ALD is considered as one of the most prevalent causes of liver disease-associated mortality worldwide. Although the pathogenesis of ALD has been intensively investigated, the present understanding of its biomarkers in the context of early clinical diagnosis is not complete, and novel therapeutic targets that can significantly alleviate advanced forms of ALD are limited. While alcohol abstinence remains the primary therapeutic intervention for managing ALD, there are currently no approved medications for treating ALD. Furthermore, given the similarities and the differences between ALD and non-alcoholic fatty liver disease in terms of disease progression and underlying molecular mechanisms, numerous studies have demonstrated that many therapeutic interventions targeting several signaling pathways, including oxidative stress, inflammatory response, hormonal regulation, and hepatocyte death play a significant role in ALD treatment. Therefore, in this review, we summarized several key molecular targets and their modes of action in ALD progression. We also described the updated therapeutic options for ALD management with a particular emphasis on potentially novel signaling pathways.

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Section: Pathophysiology Of Aldmentioning

confidence: 99%

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives

Jeong

Kim

2022

Biomedicines

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“…ROS originate in the reaction of oxygen’s reduction to water. This process involves the action of mitochondrial complexes, NADPH oxidases, peroxisomes, the microsomal electron transport chain, oxidase, cyclooxygenases, and xanthine oxidase [ 21 ]. Mitochondria are important in forming ROS, namely by means of the electron transport chain.…”

Section: Cellular Reactive Speciesmentioning

confidence: 99%

“…If electrons leak before the reduction of O 2 to water, direct one-electron reduction of O 2 generates superoxide anion ( • O 2 − ). In mitochondria, complexes I and III produce the highest amount of superoxide [ 7 , 21 ].…”

Section: Cellular Reactive Speciesmentioning

confidence: 99%

“…The cells contain peroxidase enzymes catalyzing the reaction of H 2 O 2 detoxification to water. In the cytoplasm, another hydrogen peroxide and superoxide source is the xanthine oxidoreductase complex [ 9 , 21 ]). Hydrogen peroxide can be converted to a highly reactive hydroxyl radical by exposure to UV light or by reaction with transition metal ions.…”

Section: Cellular Reactive Speciesmentioning

confidence: 99%

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Salivary Redox Homeostasis in Human Health and Disease

Čižmárová

Tomečková

Hubková

et al. 2022

IJMS

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Homeostasis is a self-regulatory dynamic process that maintains a stable internal environment in the human body. These regulations are essential for the optimal functioning of enzymes necessary for human health. Homeostasis elucidates disrupted mechanisms leading to the development of various pathological conditions caused by oxidative stress. In our work, we discuss redox homeostasis and salivary antioxidant activity during healthy periods and in periods of disease: dental carries, oral cavity cancer, periodontal diseases, cardiovascular diseases, diabetes mellitus, systemic sclerosis, and pancreatitis. The composition of saliva reflects dynamic changes in the organism, which makes it an excellent tool for determining clinically valuable biomarkers. The oral cavity and saliva may form the first line of defense against oxidative stress. Analysis of salivary antioxidants may be helpful as a diagnostic, prognostic, and therapeutic marker of not only oral, but also systemic health.

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“…Balance exists between ROS and antioxidants under normal physiological conditions. Oxidative stress only occurs when the antioxidant defense system cannot neutralize the increased amount of ROS ( 17 , 18 ). Consequently, promising therapies to prevent the formation of oxidative stress or improve the capacity of the antioxidant system have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Global trends in research on oxidative stress associated with periodontitis from 1987 to 2022: A bibliometric analysis

Xin

Xiang

et al. 2022

Front. Immunol.

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BackgroundOxidative stress has been implicated in many chronic inflammatory diseases, including periodontitis. To date, however, only a few bibliometric analyses have systematically studied this field. This work sought to visualize research hot spots and trends in oxidative stress associated with periodontitis from 1987 to 2022 through bibliometric approaches.MethodsThe Web of Science Core Collection was searched to retrieve relevant publications. HistCite, VOSviewer, and CiteSpace were used to perform bibliometric analysis visually in terms of annual output, active countries, prolific institutions, authors, core journals, co-cited references, and co-occurrence of keywords.ResultsA total of 1654 documents were selected for analysis. From 1 January 1987 to 11 June 2022, the number of annual publications related to oxidative stress in periodontitis exhibited an upward trend. The most prolific country was China with 322 documents, but the United States had 11334 citations. Okayama University, University of Birmingham, and Sichuan University were the most active and contributive institutions. The Journal of Periodontology ranked first in terms of numbers of publications and citations. Ekuni was the most prolific author, while Chapple ranked first among co-cited authors. The Role of Reactive Oxygen and Antioxidant Species in Periodontal Tissue Destruction published by Chapple was the most frequently co-cited reference. Keywords co-occurrence showed that oxidative stress was closely related to inflammation, antioxidants, and diabetes.ConclusionOur research found that global publications regarding research on oxidative stress associated with periodontitis increased dramatically and were expected to continue increasing. Inflammation and oxidative stress, and the relationship between periodontitis and systemic diseases, are topics worthy of attention.

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Oxidative Stress, Genomic Integrity, and Liver Diseases

Cited by 56 publications

References 189 publications

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives

Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives

Salivary Redox Homeostasis in Human Health and Disease

Global trends in research on oxidative stress associated with periodontitis from 1987 to 2022: A bibliometric analysis

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