Oxidative stress, hemato-immunological, and intestinal morphometry changes induced by ochratoxin A in APRI rabbits and the protective role of probiotics

El-Deep, M. H.; Amber, Khairy; Elgendy, Salwa A.; Dawood, Mahmoud A.O.; Elwakeel, Enas M; Paray, Bilal Ahamad

doi:10.1007/s11356-020-09837-3

Cited by 15 publications

(13 citation statements)

References 54 publications

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“…Rabbit meat offers excellent nutritive and dietetic properties for the consumers' needs as a rich source for animal protein (20-21%) (1,2). Furthermore, it has high levels of zinc, iron, selenium, potassium, magnesium, and vitamin B, as well as low cholesterol and sodium levels (3).…”

Section: Introductionmentioning

confidence: 99%

“…The continuous application of chemotherapies weakens the natural immunity of rabbits, and its prolonged usage induces accumulated amounts in animals' meat which can transfer to the human body and threatens the natural resistance against invaders (2,8). Especially after the COVID-19 pandemic, it becomes crucial to look for "alternative friendly additives" which can replace the routine usage of drugs, antibiotics, and vaccines in the field of rabbits' production (9).…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Dietary Chicken Egg Lysozyme on the Growth Performance, Blood Health, and Resistance Against Escherichia coli in the Growing Rabbits' Cecum

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Influence of Dietary Chicken Egg Lysozyme on the Growth Performance, Blood Health, and Resistance Against Escherichia coli in the Growing Rabbits' Cecum

et al. 2020

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“…Aflatoxin B1, OTA, and zearalenone combined with goat milk have been reported to significantly increase serum MDA, while SOD, and T-AOC levels decreased significantly ( 25 ). Dietary OTA decreased the antioxidant capacity of the intestine and increased the content of MDA ( 26 , 27 ). No information appears to be available in the literature regarding the effect of embryos exposed to OTA for the intestinal antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of embryo injected with ochratoxins A on hatching quality and jejunum antioxidant capacity of ducks at hatching

Liu

Jiang²,

Peng³

et al. 2022

Front. Vet. Sci.

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Numerous studies have shown that ochratoxins A (OTA) exerts diverse toxicological effects, namely, hepatotoxicity, nephrotoxicity, genotoxicity, enterotoxicity, and immunotoxicity. The main objective of this study was to investigate the influence of embryonic exposure to OTA by different injection times and OTA doses on hatching quality and jejunal antioxidant capacity of ducks at hatching. In total, 480 fertilized eggs were weighed and randomly assigned into a 4 × 4 factorial design including four OTA doses (0, 2, 4, and 8 ng/g egg) on 8, 13, 18, and 23 of embryonic development (E8, E13, E18, and E23). Each treatment included 6 repeats with 5 eggs per repeat. The results showed that the injection time affected the hatching weight (P < 0.0001). The relative length of the jejunum and ileum on E18 and E23 was lower than on E8 and E13 (P < 0.05). Injection time, doses, and their interaction had no effect on jejunum morphology, namely, villous height (Vh), crypt depth (Cd), and villous height/crypt depth ratio Vh/Cd (P > 0.05). The injection time affected the activities of Superoxide dismutase (SOD) (P < 0.0001), total antioxidant capacity (T-AOC) (P < 0.05) and the malondialdehyde (MDA) content (P < 0.0001). The activity of SOD and T-AOC activities in the jejunum of ducklings injected with OTA at the E8 and E13 was lower than that injected at the E18 (P < 0.05). The highest MDA content was observed in ducklings injected with OTA at the E13 (P < 0.05). The injection time (P < 0.0001), OTA doses and their interaction affected the contents of IL-1β (P < 0.05), which significantly increased especially on E13. In conclusion, the embryo injected with ochratoxins A affected the hatching weight, the relative length of jejunum and ileum, decreased the antioxidant capacity and increased the content of proinflammatory cytokine IL-1β of the jejunum.

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“…Therapeutics are no longer recommended for poultry production, and their usage is restricted in several countries, especially for organic food production (22). Phytogenic additives are applied in the modern poultry industry for their beneficial and promoting influences on the growth performance, immune response, and resistance against farming stressors (7).…”

Section: Discussionmentioning

confidence: 99%

Enhancing the Growth Rate, Biochemical Blood Indices, and Antioxidative Capacity of Broilers by Including Aloe vera Gel in Drinking Water

et al. 2021

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Phytogenic herbal extracts received considerable attention in the broilers industry as friendly alternative substitutes to antibiotics. These additives can be included in the food or drinking water to enhance birds' growth rate and well-being. Hence, the current investigation examined the effect of including Aloe vera gel in drinking water on the growth rate, biochemical blood indices, and broilers' antioxidative capacity. Cobb 500 broiler chicks (n = 120), 1 day old of initial weight = 48.6 ± 1.65 g, were divided into three treatments where the control group was fed the basal diet without including Aloe vera gel in drinking water. The second and third groups were fed the basal diet, and Aloe vera gel was included in drinking water at 1 and 1.5%, respectively. The final body weight, weight gain, daily weight gain, and feed conversion ratio were significantly improved in birds that received drinking water with Aloe vera gel at 1.5% compared to the control and 1% groups (P ≤ 0.05). The kidney (creatinine and urea) and liver (ALT and AST) function indices of broilers that received drinking water with or without Aloe vera gel showed no significant differences with the control group (P ≥ 0.05). The blood total protein and albumin had higher values in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). The total blood cholesterol, triglycerides, and LDL levels were significantly decreased in the group of birds that received 1.5% Aloe vera gel in drinking water (P ≤ 0.05). The HDL level was higher in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). The total antioxidative capacity (TAC) and glutathione peroxidase (GPX) showed higher activity in the group of birds that received 1.5% Aloe vera gel while the level of malondialdehyde (MDA) was lower in birds that received drinking water with 1.5% Aloe vera gel than the control (P ≤ 0.05). In summary, including Aloe vera gel in drinking water enhanced the growth rate, biochemical blood indices, and broilers' antioxidative capacity.

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Oxidative stress, hemato-immunological, and intestinal morphometry changes induced by ochratoxin A in APRI rabbits and the protective role of probiotics

Cited by 15 publications

References 54 publications

The Influence of Dietary Chicken Egg Lysozyme on the Growth Performance, Blood Health, and Resistance Against Escherichia coli in the Growing Rabbits' Cecum

The Influence of Dietary Chicken Egg Lysozyme on the Growth Performance, Blood Health, and Resistance Against Escherichia coli in the Growing Rabbits' Cecum

Effects of embryo injected with ochratoxins A on hatching quality and jejunum antioxidant capacity of ducks at hatching

Enhancing the Growth Rate, Biochemical Blood Indices, and Antioxidative Capacity of Broilers by Including Aloe vera Gel in Drinking Water

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