Oxidative Stress in Adult Dengue Patients

Gil, Lizette; Martı́nez, Gregorio; Tápanes, Rolando; Castro, Osvaldo; González, Daniel; Bernardo, Lídice; Vázquez, Susana; Kourí, Gustavo; Guzmán, María G.

doi:10.4269/ajtmh.2004.71.652

Cited by 75 publications

(71 citation statements)

References 31 publications

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“…[2] The pathogenesis of thrombocytopenia in dengue fever is not clear but increased oxidative stress may have a role. [3,4] Vitamin E which has antioxidant and free-radical scavenging properties and may therefore help in these cases. [5,6] Hence, in the present study, we have evaluated the effect of vitamin E on thrombocytopenia in the cases of dengue fever.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin E on thrombocytopenia in dengue fever

Vaish¹,

Verma²,

Agarwal³

et al. 2012

Ann Trop Med Public Health

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Context: Dengue fever frequently causes thrombocytopenia for which there is no satisfactory treatment. Aim: To evaluate the effect of vitamin E on thrombocytopenia in dengue fever. Settings and Design: A tertiary teaching hospital during a recent outbreak of dengue fever in the area. Materials and Methods: Patients of dengue fever (as per WHO criteria) with thrombocytopenia and platelet counts between 10 × 10 3 /mm 3 and 100 × 10 3 /mm 3 seen during were enrolled. After detailed history and clinical evaluation, the patients were randomized to two groups -group I which received vitamin E 400 mg (Evion, Merck) once daily along with standard treatment and group II which received standard treatment only. The platelet counts, bleeding manifestations, requirement for platelet transfusion were serially monitored for up to 1 week in these cases. Statistical Analysis Used: Percentage, mean, standard error of mean, Mann-Whitney U test, and Chi-square test. Results: We enrolled 66 cases (group I -33 and group II -33). Mean platelet count at baseline in both the groups was similar (group I -28.39 ± 1.61 × 10 3 /mm 3 and group II -27.64 ± 1.65 × 10 3 /mm 3 ) (P > 0.05). We observed that the mean platelet count on day 4 in group I (vitamin E) was significantly higher (Mean -122.19 ± 9.98 × 10 3 /mm 3 ; CI 95% -102.63 × 10 3 /mm 3 -141.76 × 10 3 /mm 3 ) than in group II (Mean -92.57 ± 7.93 × 10 3 /mm 3 ; CI 95% -77.03 × 10 3 /mm 3 -108.11 × 10 3 /mm 3 ) (P = 0.0436). Similar findings were also observed on day 7 in the two groups. Platelet transfusion was required in less cases in group I [2 out of 33 (6.06%)] as compared to group II [5 out of 33 (15.15%)]. Conclusion: We conclude that vitamin E is beneficial in thrombocytopenia in dengue fever and results in faster increase in the platelet counts.

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Section: Introductionmentioning

confidence: 99%

Effect of vitamin E on thrombocytopenia in dengue fever

Vaish¹,

Verma²,

Agarwal³

et al. 2012

Ann Trop Med Public Health

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“…GSH, catalase (CAT), thioredoxin (Trx) and superoxide dismutase (SOD) produce the environment in the cell that acts against the oxidants and keep the reducing environment in the cell [5] . OS due to effect of dengue infection on protein-bound sulphydryls in human plasma is not well understood [6] . In dengue patients, increased levels of total antioxidant status (TAS) like SOD, GSH, and LPO have been observed, and decreased levels of glutathione peroxidase (GPx) and total hydroperoxides (THP) have been observed as compared to normal [7] .…”

mentioning

confidence: 99%

Assessment of biochemical and antioxidative status in patients suffering from dengue fever

Rasool

Malik

Khan

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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A multi-centred study was designed to collect dengue epidemiologic data from government and registered private hospitals/clinics and maintained archive of frozen specimens in bio-bank to be used for future dengue epidemic control program, and assess the epidemiology of dengue fever (DF) by evaluating biochemical and oxidative status of patients. ELISA IgM antibodies test was done to confirm DF. From August 2010 to December 2011, 101 confirmed blood samples of DF patients referred to pathology lab of Jinnah Hospital Lahore were subjected to the epidemiologic assessment by evaluating the biochemical and physiological indices and alterations of circulating antioxidants. Clinical features of DF patients and effect of fever on blood components and serum proteins of liver were recorded. The hospital stay in DF, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) showed significant difference. Significant increases in serum alanine amino transferase (ALT) (P=0.000), aspartate amino transferase (AST) (P=0.000), alkaline phosphatase (ALP) (P=0.000), malondialdehyde (MDA) along with significant decreases in total protein (TP) (P=0.000), reduced glutathione (GSH) (P=0.000), superoxide dismutase (SOD), catalase (CAT) (P=0.000), and sialic acid contents (P=0.016) were observed. A positive correlation existed between bound sialic acid levels, liver enzymes and circulating antioxidants (r=0.656, P=0.016). In the present study, alterations of circulating antioxidants in DF suggest that DF might be a metabolic response to an acute, self-limiting tropical viral infection, and a consequence of the viral inflammatory process.

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“…It is based on a recent investigation compared HO-1 production by monocytes in vivo in various acute inflammatory illnesses and in healthy controls. Significantly elevated HO-1 mRNA levels seen in acute inflammatory illnesses suggest that monocyte production of HO-1 serves as a potent anti-inflammatory agent in controlling excessive cell or tissue injury in the presence of oxidative stress and cytokinemia [19]. 4) Dengue virus infection could interfere the intracellular iron metabolism; this may trigger the Fenton reaction, thus producing hydroxyl radicals, which are highly toxic to cells.…”

Section: Resultsmentioning

confidence: 99%

A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index

Hartoyo

Thalib²,

Sari³

et al. 2017

J.Trop.Life.Science

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The objectives of this study were to determine the involvement of Oxidative Stress (OS) in the pathogenesis of dengue hemorrhagic fever (DHF) through the analysis of oxidative stress Index (OSI). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity, and OSI were measured in 61 child dengue patients and (aged 6 months-18 years) with three different stages of DHF, i.e stage I, II, and III. The results show that the levels of MDA, SOD and CAT activity, and OSI significantly different between the group. The all parameters that investigated in this present study seems higher MDA level and OSI in the higher grade of DHF, except for SOD and CAT activity. From this result, it can be concluded that oxidative stress pathways might be involved in the pathomechanism of DHF and OSI might be used as a biomarker for OS and the severity in DHF patients.

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Oxidative Stress in Adult Dengue Patients

Cited by 75 publications

References 31 publications

Effect of vitamin E on thrombocytopenia in dengue fever

Effect of vitamin E on thrombocytopenia in dengue fever

Assessment of biochemical and antioxidative status in patients suffering from dengue fever

A Different Approach to Assess Oxidative Stress in Dengue Hemorrhagic Fever Patients Through The Calculation of Oxidative Stress Index

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