Oxidative stress in alcoholic and viral hepatitis

Kundu, Debtosh; Mandal, Tanuka; Bandyopadhyay, Ujjwal; Ghosh, Enakshi; Ray, Debes

doi:10.4103/1947-2714.100993

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…These studies mostly measured MDA as an oxidation marker, which was significantly higher in patients with hepatitis B infection compared to healthy individuals (Table 1); a marker that was positively correlated to alanine aminotransferase (ALT) (23-25, 30, 31, 41), HBV-DNA (23, 32), total and direct bilirubin (28), serum bcl-2 (this study combined hepatitis B and C patients) (47), gamma-glutamyl transpeptidase (GGT) (31), serum iron/ferritin (44), and liver ultrasonography findings (coarse texture) (28) in some studies. Although another study demonstrated a significant increase in the MDA levels of chronic hepatitis B patients, it did not find a significant difference between inactive HBsAg carriers and controls (48).…”

Section: Resultsmentioning

confidence: 99%

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Hepatitis B and its Relationship With Oxidative Stress

Alavian

Showraki

2016

Hepat Mon

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ContextDespite the great breakthroughs we have witnessed in the last 50 years in the prevention, diagnosis, and treatment of hepatitis B, we are still far from eradicating or even curing the disease. Achieving further progress in controlling this disease will not be possible without discovering the exact pathogenesis behind it. One prime suspect in the pathogenesis of various diseases is oxidative stress. This review will exclusively explore hepatitis B in the context of oxidative stress to obtain a more comprehensive clinical perspective on its pathogenesis and eventual medical therapy.Evidence AcquisitionWe systematically searched PubMed, Google Scholar, Web of Science, EMBASE, and Scopus using an extensive list of keywords in the following three categories: 1) Hepatitis B and oxidation 2) Hepatitis B and antioxidant system 3) Effects of approved anti-hepatitis B drugs on redox status. All relevant articles were obtained and reviewed carefully after the exclusion criteria were deployed.ResultsThere is great evidence indicating extensive oxidative stress occurs in hepatitis B. This oxidative stress takes place on multiple levels, including lipid peroxidation, DNA oxidation, protein oxidation, and reactive oxygen and nitrogen species production. However, there are also conflicting results with regard to antioxidant therapy and antioxidant status in hepatitis B, some of which may be explained by the concept of “compensatory gaps.” Nevertheless, further studies are indicated to reach a more thorough judgment.ConclusionsDespite the presence of vast oxidative stress in hepatitis B, antioxidant therapy is not always effective as a treatment strategy, especially considering that antioxidants can act as “double-edged swords” or antioxidants; if not used at the right time or place or in the right combination, these substances can easily become pro-oxidants. Therefore, several studies will be needed to determine suitable antioxidant therapies. We propose the “2-step Combined Antioxidant Adjuvant Therapy for hepatitis B (2CAAT Hep B)” as a new strategy for antioxidant adjuvant therapy. We also suggest developing an international platform and database for antioxidant adjuvant therapy in hepatitis B (IPAATH and IDAATH) to canalize this field of research in a standardized direction, especially when complexity is a problem.

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Section: Resultsmentioning

confidence: 99%

“…Table 2 summarizes studies that have revealed the status of some antioxidants in patients with hepatitis B (21-24, 27-29, 31-34, 37-39, 41, 43, 44, 46, 48, 49, 53, 61, 63, 64, 73, 80, 84-93). Table 3 shows several studies on the effect of some antioxidant therapies in patients with hepatitis B (94-102).…”

Section: Resultsmentioning

confidence: 99%

Hepatitis B and its Relationship With Oxidative Stress

Alavian

Showraki

2016

Hepat Mon

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“…Although the underlying mechanisms are not completely understood, oxidative stress appears to be the major pathogenic event occurring through the duration of the disease [16][17][18][19][20][21] . Previous studies also found significantly increased ROS in the liver of patients with viral hepatitis [22][23][24][25] and alcoholic liver disease [26][27][28] .…”

Section: Ros and Nafldmentioning

confidence: 72%

ROS correlates intimately with the progression of non-alcoholic fatty liver disease to hepatocarcinoma

Yuan¹,

Li²,

Dong³

2015

Can Cell Microenviron

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The prevalence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing. NAFLD affects the health of one-third of the world's population in forms that range from simple steatosis to hepatocellular injury, inflammation, fibrosis, liver cirrhosis and hepatocarcinoma. Oxidative stress in the progression of NAFLD to hepatocarcinoma is gaining increasing attention. Sustained and excessive reactive oxygen species (ROS), which lead to oxidative stress, are involved in all pathophysiological stages of NAFLD and contribute to the occurrence of hepatocarcinoma. Antioxidants in natural plant extracts that activate nuclear factor related to E2 factor 2 (Nrf2) can effectively suppress the progression. The cellular anti-oxidative system has great importance in the prevention and reversal of NAFLD. This review summarizes the current knowledge of the involvement of oxidative stress in NAFLD to hepatocarcinoma. To cite this article: Yuan Yan, et al. ROS correlates intimately with the progression of non-alcoholic fatty liver disease to hepatocarcinoma.

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“…[1456] Several studies have reported the potential role of dietary antioxidant intake in the protection against oxidative stress and accompanied clinical complications. [247]…”

Section: Introductionmentioning

confidence: 99%

Micronutrient intake and the presence of the metabolic syndrome

et al. 2013

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Background:Dietary micronutrients have been proposed to protect against oxidative damage and related clinical complications.Aims:We aimed to compare the micronutrient intake between individuals with and without metabolic syndrome (MS).Materials and Methods:This cross-sectional study included 3800 men and women who were aged between 35 and 65 years. The diagnosis of the MS was based on International Diabetes Federation criteria. Dietary intake of participants was assessed using a questionnaire for 24 h dietary recall. Student's t-test and Mann–Whitney U-tests were used for comparing the micronutrient intake of subjects with or without the MS and the odds ratio for the presence of the MS was calculated for each micronutrient by control for total energy intake adjusted by the residue method.Results:The mean age of MS subjects and the control group was 48.8 ± 7.9 years and 47.6 ± 7.6 years, respectively. Energy-adjusted intake of vitamin E (P < 0.05), B2 (P < 0.01), and B12 (P < 0.05) was higher in normal women compared with women with MS. Energy-adjusted intake of vitamin B1 was significantly higher in women with MS. After logistic regression analysis, no significant association between micronutrient intake and MS was shown.Conclusion:We found no significant association between micronutrient intake and MS.

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Oxidative stress in alcoholic and viral hepatitis

Cited by 11 publications

References 12 publications

Hepatitis B and its Relationship With Oxidative Stress

Hepatitis B and its Relationship With Oxidative Stress

ROS correlates intimately with the progression of non-alcoholic fatty liver disease to hepatocarcinoma

Micronutrient intake and the presence of the metabolic syndrome

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