Oxidative stress in bipolar and schizophrenia patients

Tunçel, Özgür Korhan; Sarısoy, Gökhan; Bilgici, Birşen; Pazvantoğlu, Ozan; Çetin, Eda; Ünverdi, Esra; Avcı, Bahattin; Böke, Ömer

doi:10.1016/j.psychres.2015.04.046

Cited by 56 publications

(33 citation statements)

References 73 publications

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“…In particular, there is strong evidence for elevated lipid peroxidation in post‐mortem brain tissue and peripheral blood from subjects with bipolar disorder. In addition, previous studies of bipolar disorder have demonstrated increased levels of lipid peroxidation in drug‐naïve patients, across the disorder's mood phases, and in adolescents with the disorder . Of particular significance for this study, peripheral blood indices of oxidative lipid damage were negatively associated with frontotemporal white matter integrity in subjects with BD‐I and HCs .…”

Section: Discussionmentioning

confidence: 62%

“…Increasing evidence suggests that oxidative stress is involved in the pathophysiology of bipolar disorder . Previous studies, which mainly examined patients with BD‐I or mixed samples of patients with BD‐I and BD‐II, consistently found elevated levels of oxidative stress in blood and brain tissue from subjects with bipolar disorder . Increased oxidative stress can damage several cellular components, including membrane‐bound polyunsaturated fatty acids and nucleic acids, and might thereby compromise neuronal viability in bipolar disorder .…”

Section: Introductionmentioning

confidence: 99%

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Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross‐sectional analyses

et al. 2016

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross‐sectional analyses

et al. 2016

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“…Consistent with evidence from other studies, our findings suggest brain oxidative stress and altered energy production in SZ. [9][10][11][33][34][35] Since RR can affect numerous critical enzymatic reactions, our findings for reduced RR in both FE and chronic SZ patients provide an important new insight into the pathophysiology of this major psychiatric condition.…”

Section: Discussionmentioning

confidence: 69%

Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement

Kim

Cohen

Chen

et al. 2016

Schizophrenia Bulletin

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Balance between the redox pair of nicotinamide adenine dinucleotides (oxidized NAD+ and reduced NADH), reflects the oxidative state of cells and the ability of biological systems to carry out energy production. A growing body of evidence suggests that an "immuno-oxidative" pathway including oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell-mediated immune response may contribute to disruptions in brain activity in schizophrenia (SZ). The aim of this study is to assess possible redox imbalance in SZ patients by using a novel in vivo 31 P MRS technique. The participants included 40 healthy controls, 21 chronic SZ, 13 first-episode (FE) SZ, and 18 FE bipolar disorder (BD) patients (as a psychiatric control group). All participants initially underwent structural imaging at a 3 Tesla (3 T) and 31 P MRS measurements were performed on a 4 T MR scanner. NAD+ and NADH components were determined by nonlinear least-square fitting of the model simulated spectra; these incorporated prior chemical shift and coupling constant information to in vivo resonances obtained from 31 P MRS experiments. We found a significant reduction in the NAD+/NADH ratio in chronically ill SZ patients compared to a matched healthy control group, and in FE SZ patients compared to both a matched FE BD patient group and a matched healthy control group. These findings provide evidence for redox imbalance in the brain in all phases of SZ, potentially reflecting oxidative stress.

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“…4,5 Increasing evidence supports that the pathophysiology of SCZ involves oxidative stress. 6,7 Abnormal oxidative stress parameters have been reported in blood, cerebrospinal fluid, red blood cells, platelets, and neutrophils in patients with SCZ. [8][9][10][11][12] Oxidative stress is closely linked to diverse physiological and pathological processes, such as inflammation, mitochondrial dysfunction, oligodendrocyte abnormalities, and the impairment of gamma-aminobutyric acid interneurons.…”

Section: Introductionmentioning

confidence: 99%

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

Yan¹,

Duan²,

Fu³

et al. 2020

NDT

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Background: Glutathione S-transferase (GST) is an important antioxidant enzyme in the body. The weakening of the antioxidant system causes damage to the cells and tissues that make up the organism, adversely affects the function of the nervous system, and ultimately leads to schizophrenia (SCZ). Previous studies have yielded inconsistent results across different ethnic populations. Purpose: This case-control study was carried out to investigate whether genetic polymorphisms in GST could be associated with SCZ in the Chinese Han population. Patients and Methods: A total of 794 participants, including 379 SCZ patients (case group) and 415 healthy individuals (control group), were genotyped by polymerase chain reaction-restriction fragment length for polymorphisms in GST genes. Results: The study found that the frequency of the GSTM1 null genotype was higher in case group than control group (p=0.003). The frequency of the GSTM1 and GSTT1 double null genotype was also higher in case group than control group (p=0.008). Conclusion: We conclude that the GSTM1 null genotype and the GSTM1 and GSTT1 double null genotype may be related to the onset of SCZ in Chinese Han population.

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Oxidative stress in bipolar and schizophrenia patients

Cited by 56 publications

References 73 publications

Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross‐sectional analyses

Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross‐sectional analyses

Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement

<p>Association Between Glutathione S-Transferase (GST) Polymorphisms and Schizophrenia in a Chinese Han Population</p>

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