Oxidative stress in patients with essential hypertension: A comparison of dippers and non-dippers

Gönenç, Aymelek; Hacışevki, Aysun; Tavıl, Yusuf; Çengel, Atiye; Torun, Meral

doi:10.1016/j.ejim.2012.08.016

Cited by 37 publications

(31 citation statements)

References 39 publications

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“…Red cell distribution width, which is closely related to adverse cardiovascular outcomes, was higher in nondippers compared to dippers (14.1% ± 1.33% versus 13.5% ± 0.89%, P = 0.008) 16. Oxidative stress is higher in nondippers compared to dippers as evidenced by increased levels of asymmetric dimethyl arginine among nondippers ( P < 0.01) 17. Mean platelet volume, which is a determinant of platelet activation, was higher among nondippers compared to dippers (9.72 ± 0.52 fL versus 9.38 ± 0.33 fL, P < 0.05) 18.…”

Section: Association Of Nondippers With Risk Factors and Target Organmentioning

confidence: 91%

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Chakrapani¹,

Kamath²,

Unnikrishnan³

et al. 2013

VHRM

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Hypertension is a major independent risk factor for cardiovascular diseases. Management of hypertension is generally based on office blood pressure since it is easy to determine. Since casual blood pressure readings in the office are influenced by various factors, they do not represent basal blood pressure. Dipping of the blood pressure in the night is a normal physiological change that can be blunted by cardiovascular risk factors and the severity of hypertension. Nondipping pattern is associated with disease severity, left ventricular hypertrophy, increased proteinuria, secondary forms of hypertension, increased insulin resistance, and increased fibrinogen level. Long-term observational studies have documented increased cardiovascular events in patients with nondipping patterns. Nocturnal dipping can be improved by administering the antihypertensive medications in the night. Long-term clinical trials have shown that cardiovascular events can be reduced by achieving better dipping patterns by administering medications during the night. Identifying the dipping pattern is useful for decisions to investigate for secondary causes, initiating treatment, necessity of chronotherapy, withdrawal or reduction of unnecessary medications, and monitoring after treatment initiation. Use of this concept at the primary care level has been limited because 24-hour ambulatory blood pressure monitoring has been the only method for documenting dipping/nondipping status so far. This monitoring technique is expensive and inconvenient for routine usage. Simpler methods using home blood pressure monitoring systems are evolving to document basal blood pressure in the night, which would help in greater acceptance and use of the concept of dipper/nondipper in managing hypertension at the primary care level.

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Section: Association Of Nondippers With Risk Factors and Target Organmentioning

confidence: 91%

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Chakrapani¹,

Kamath²,

Unnikrishnan³

et al. 2013

VHRM

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“…The imbalance that leads to oxidative stress may be due to decreased TAC as well as to increased ROS levels [35][36][37][38]. The sum of levels of non-enzymatic antioxidants called as total antioxidant activity or TAC may be indicative of the extent of oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

Pekel

Gönenç

Turhan

et al. 2014

J Assist Reprod Genet

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Purpose The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. Methods This study included 109 patients. Patients were classified as unexplained infertility (N=31), PCOS (N=19), tubal factor (N=9) and endometriosis (N=10) and compared with male factor infertility (N=40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Results Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p<0.01, p<0.05, p<0.05). However, SOD activity in unexplained infertility, PCOS and endometriosisgroupswere significantly higher than control group (p<0.01).Decreased follicular fluid TAC levels were found in all patient groups compared with controls (respectively, p<0.01, p<0.05, p<0.01, p<0.01).Patients with tubal factor had significantly higher serum sFasL (p<0.05), but lower follicular fluid sFasL levels (p<0.05) compared with unexplained infertility. Tubal factor and endometriosis groups had lowerfollicular fluid TAC levels compared to unexplained infertility and PCOSgroups (p<0.01). Conclusion(s) In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in infertility, possibly implying increased apoptosis. Especially in unexplained infertility group changes in this parametres more remarkable.

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“…In fact, what it does measure is low molecular antioxidants, phytochemicals, antioxidant minerals and some other important antioxidant such as α‐lipoic acid . It has been shown that TAC levels were reduced in hypertension, CVD and DM . Finally, there are data showing a correlation between F 2 ‐IsoPs and TAC in DM …”

Section: Introductionmentioning

confidence: 99%

Enhanced oxidative stress and platelet activation in patients with Cushing's syndrome

Karamouzis

Berardelli

D’Angelo

et al. 2014

Clinical Endocrinology

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Summary Objective Cushing Syndrome (CS) is implicated by increased cardiovascular risk (CVR) leading to increased morbidity and mortality. Oxidative stress (OS) and platelet activation (PA) are associated with increased CVR. However, scarce data of OS in CS exist. Our objective was to determine the oxidant–antioxidant balance in CS. Design Fourteen patients with CS at diagnosis and fourteen healthy subjects (NS) were evaluated OS by measuring plasma 15‐F2t‐Isoprostane (15‐F2t‐IsoP), PA by thromboxaneB2 levels (TXB2), and antioxidant reserve measuring total antioxidant capacity (TAC) and serum vitamin E. Results 15‐F2t‐IsoP and TXB2 levels were significantly higher (P < 0·01) in CS, while vitamin E levels were higher in NS (P < 0·03). 15‐F2t‐IsoP levels were significantly higher (P < 0·01) in complicated vs not‐complicated CS and NS and significantly higher (P < 0·03) in CS not‐complicated vs NS. TXB2 levels were significantly reduced (P < 0·03) in NS vs complicated and not‐complicated CS. A negative correlation between Vitamin E and UFC was observed in CS (P < 0·05 r = −0·497). TXB2 correlated with glucose, HbA1c and T‐score (P < 0·05 r = 0·512, P < 0·03 r = 0·527 and P < 0·01 r = 0·783, respectively) and HDL (P < 0·01 r = −0·651). 15‐F2t‐IsoP correlated with triglicerides, HbA1c and diastolic pressure (P < 0·01 r = 0·650, P < 0·03 r = 0·571 and P < 0·05 r = 0·498, respectively) and HDL (P < 0·03 r = −0·594). Conclusions This study emphasizes the major role of OS in CS. As our findings demonstrated that enhanced OS and PA take place in this rare metabolic disorder which is associated with increased CVR, it could be suggested that these biochemical alterations can further contribute in the pathogenesis of atherosclerosis, increased CVR and mortality in CS.

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Oxidative stress in patients with essential hypertension: A comparison of dippers and non-dippers

Cited by 37 publications

References 39 publications

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

Enhanced oxidative stress and platelet activation in patients with Cushing's syndrome

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