Oxidative stress in primary glomerular diseases: a comparative study

Markan, Suchita; Kohli, Harbir Singh; Sud, Kamal; Ahuja, Monica; Ahluwalia, Tarunveer S.; Sakhuja, Vinay; Khullar, Madhu

doi:10.1007/s11010-008-9701-0

Cited by 15 publications

(19 citation statements)

References 22 publications

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“…Oxidative stress is a phenomenon associated with pathogenetic mechanisms of several diseases, including atherosclerosis, cancer, diabetes mellitus and inflammatory diseases, as well as with aging processes. The levels of oxidative stress markers in plasma and urine, especially of 8-isoprostane, HNE and MDA, reportedly reflect systemic production in diseases such as diabetes 7) , hypertension 8) and renal diseases 9) .…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

et al. 2011

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Exhaled breath condensate (EBC) is assumed to reflect processes in the lungs, yet itis unknown whether oxidative stress markers in EBC are affected by systemic disorders (atherosclerosis, hypertension, diabetes) or whether lung diseases increase markers in plasma and urine. 8-isoprostane, 4-hydroxy-trans-2-nonenale (HNE) and malondialdehyde (MDA) were measured using liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) in EBC, plasma and urine in 82 patients (45 with asbestosis and hyalinosis, and 37 with silicosis) and in 29 control subjects. 8-isoprostane and HNE in EBC, and HNE in urine were higher in both groups of patients. In addition, 8-isoprostane in plasma and urine, and MDA in urine were higher in asbestos-exposed patients and MDA in plasma in silicotics, with this marker in plasma correlated with the grade of silicosis. In all subjects, 8-isoprostane in EBC correlated with urine (r=0.38, p<0.001) and plasma levels (r=0.28, p=0.003), and HNE and MDA with urine levels (r=0.31, p<0.001; r=0.23, p=0.016, respectively). Most markers positively correlated with lung function impairment, EBC markers negatively with vitamin E supplementation. To conclude: The influence of satisfactorily controlled systemic disorders on markers in EBC in patients with pneumoconioses is not significant. In addition to oxidative stress markers in EBC, lung fibroses may increase oxidative stress markers in plasma and urine.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

et al. 2011

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“…Markan et al (3) showed that pro-oxidant markers (malondialdehyde, 8-isoprostane, total homocysteine) were significantly higher and antioxidant markers (superoxide dismutase) were significantly lower in primary GN patients compared to the control subjects. When patients were grouped as PGN and NPGN; OS was shown to be significantly profound in the PGN group compared with NPGN group (3).…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, immunologic injuries are localized to the mesangium or subendothelial space directly in contact with the circulation in PGN. In addition to urinary findings, a marked inflammatory response may cause an increased level of reactive oxygen species (ROS) in PGN compared to NPGN (3).…”

Section: Introductionmentioning

confidence: 99%

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What We Do and Do not Know About Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman’s Day

Piccoli

Alrukhaimi

Liu

et al. 2018

Turk Neph Dial Transpl

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OBJECTIVE:Oxidative stress (OS) is described as the imbalance of oxidative and anti-oxidative systems towards oxidants and plays a role in the pathogenesis of GN. In many studies, ischemiamodified albumin (IMA) is identified as a sign of OS. However, it has not yet been studied in patients with primary GN in the literature. In the present study, we aimed to determine the role of IMA in the pathogenesis of primary GN. MATERIAL and METHODS:Forty-five primary GN patients were divided into two groups as proliferative GN (PGN) (n= 17, 37.8%) and non-proliferative GN (NPGN) (n= 28, 62.2%) according to the histopathological findings. IMA was studied by the cobalt binding method. Since serum albumin levels are commonly low in patients with GN, we calculated the adjusted IMA (aIMA) according to serum albumin. RESULTS:There was no significant difference between the two groups regarding IMA compared with controls (n= 50). IMA was significantly higher in the PGN group compared with the control and NPGN groups (p= 0.009, 0.037; respectively). There was a negative correlation between serum albumin concentration and IMA. CONCLUSION:These results support the role of OS in the pathogenesis of PGN in which inflammatory immune glomerular injury is predominant. KEY WORDS:Glomerulonephritis, Oxidative stress, Ischemia-modified albumin (IMA) ÖZ AMAÇ: Oksidan ve antioksidan sistemler arasındaki dengenin oksidan maddeler lehine bozulması olarak tanımlanan oksidatif stresin (OS), glomerülonefrit (GN) patogenezinde rol aldığı gösterilmiştir. İskemi modifiye albümin (İMA) birçok çalışmada OS göstergesi olarak tanımlanmıştır. Ancak literatür-de daha önce GN hastalarında çalışılmamıştır. Çalışmamızda, OS'in GN patogenezindeki rolünü, İMA ile değerlendirilmesi amaçlanmıştır. GEREÇ ve YÖNTEMLER:Kırkbeş primer GN hastası histopatolojik bulgulara göre proliferatif GN (PGN) (n= 17, %37,8) ve non-proliferatif GN (NPGN) (n= 28, %62,2) olarak iki gruba ayrıldı. İMA, albümin kobalt bağlama yöntemi ile çalışıldı. GN hastalarında serum albümin değerleri sıklıkla düşük olduğundan serum albümin konsantrasyonuna göre düzeltilmiş İMA (dİMA) hesaplaması yapıldı. BULGULAR:Kontrol grubu (n= 50) ile gruplar arasında İMA değerleri açısından fark yoktu. PGN grubunda dİMA, kontrol ve NPGN gruplarına göre anlamlı (p= 0.009, 0.037) olarak yüksekti. Serum albümin konsantrasyonu ve İMA arasında negatif korelasyon tespit edildi. SONUÇ:Elde ettiğimiz bulgular OS'in, inflamatuvar immün yanıtın belirgin olduğu PGN patogenezinde rol oynadığını desteklemektedir.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress in Primary Glomerulonephritis with Serum Level of Ischemia Modified Albumin (IMA)

Oruç¹,

Yıldız²,

Acikgoz³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: Oxidative stress (OS) is described as the imbalance of oxidative and anti-oxidative systems towards oxidants and plays a role in the pathogenesis of GN. In many studies, ischemiamodified albumin (IMA) is identified as a sign of OS. However, it has not yet been studied in patients with primary GN in the literature. In the present study, we aimed to determine the role of IMA in the pathogenesis of primary GN. MATERIAL and METHODS:Forty-five primary GN patients were divided into two groups as proliferative GN (PGN) (n= 17, 37.8%) and non-proliferative GN (NPGN) (n= 28, 62.2%) according to the histopathological findings. IMA was studied by the cobalt binding method. Since serum albumin levels are commonly low in patients with GN, we calculated the adjusted IMA (aIMA) according to serum albumin. RESULTS:There was no significant difference between the two groups regarding IMA compared with controls (n= 50). IMA was significantly higher in the PGN group compared with the control and NPGN groups (p= 0.009, 0.037; respectively). There was a negative correlation between serum albumin concentration and IMA. CONCLUSION:These results support the role of OS in the pathogenesis of PGN in which inflammatory immune glomerular injury is predominant.KEy wORDS: Glomerulonephritis, Oxidative stress, Ischemia-modified albumin (IMA) Öz AMAÇ: Oksidan ve antioksidan sistemler arasındaki dengenin oksidan maddeler lehine bozulması olarak tanımlanan oksidatif stresin (OS), glomerülonefrit (GN) patogenezinde rol aldığı gösterilmiştir. İskemi modifiye albümin (İMA) birçok çalışmada OS göstergesi olarak tanımlanmıştır. Ancak literatür-de daha önce GN hastalarında çalışılmamıştır. Çalışmamızda, OS'in GN patogenezindeki rolünü, İMA ile değerlendirilmesi amaçlanmıştır. GEREÇ ve yÖNTEMLER:Kırkbeş primer GN hastası histopatolojik bulgulara göre proliferatif GN (PGN) (n= 17, %37,8) ve non-proliferatif GN (NPGN) (n= 28, %62,2) olarak iki gruba ayrıldı. İMA, albümin kobalt bağlama yöntemi ile çalışıldı. GN hastalarında serum albümin değerleri sıklıkla düşük olduğundan serum albümin konsantrasyonuna göre düzeltilmiş İMA (dİMA) hesaplaması yapıldı. BULGULAR:Kontrol grubu (n= 50) ile gruplar arasında İMA değerleri açısından fark yoktu. PGN grubunda dİMA, kontrol ve NPGN gruplarına göre anlamlı (p= 0.009, 0.037) olarak yüksekti. Serum albümin konsantrasyonu ve İMA arasında negatif korelasyon tespit edildi. SONUÇ:Elde ettiğimiz bulgular OS'in, inflamatuvar immün yanıtın belirgin olduğu PGN patogenezinde rol oynadığını desteklemektedir.

show abstract

Oxidative stress in primary glomerular diseases: a comparative study

Abstract: Oxidative stress in PGN is significantly higher than NPGN, indicating higher oxidative stress in these patients, independent of degree of renal dysfunction.

Cited by 15 publications

References 22 publications

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

What We Do and Do not Know About Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman’s Day

Evaluation of Oxidative Stress in Primary Glomerulonephritis with Serum Level of Ischemia Modified Albumin (IMA)

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Oxidative stress in primary glomerular diseases: a comparative study

Abstract: Oxidative stress in PGN is significantly higher than NPGN, indicating higher oxidative stress in these patients, independent of degree of renal dysfunction.

Cited by 15 publications

References 22 publications

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

What We Do and Do not Know About Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman’s Day

Evaluation of Oxidative Stress in Primary Glomerulonephritis with ￼Serum Level of Ischemia Modified Albumin (IMA)

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Evaluation of Oxidative Stress in Primary Glomerulonephritis with Serum Level of Ischemia Modified Albumin (IMA)