Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems

Feillet‐Coudray, Christine; Sutra, Thibault; Fouret, G.; Ramos, Jeanne; Wrutniak‐Cabello, Chantal; Cabello, Gérard; Cristol, Jean Paul; Coudray, Charles

doi:10.1016/j.freeradbiomed.2008.11.020

Cited by 137 publications

(90 citation statements)

References 55 publications

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“…We found that high-fat diet could provoke oxidative stress and sperm damage in rats, and probiotics could repair oxidative damage and improve sperm quality to some extent. High-fat diet inducing oxidative stress has been shown in this study and was in agreement with those reported in other studies (Cui et al, 2009;Feillet-Coudray, 2009). Antioxidants can dispose, scavenge and suppress the formation of free radicals or oppose ROS chain actions in the body and play an important role in animal health.…”

Section: Discussionsupporting

confidence: 93%

Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats

Chen

Gong

2013

Animal

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In this study, antioxidant capability and protective effect of probiotics on reproductive damage induced by diet oxidative stress were investigated. Thirty male Sprague-Dawley rats were randomly divided into three groups with 10 rats in each group. The control group consumed a normal standard diet (5% fat, w/w). The other two treatment groups were fed with a high-fat diet (20% fat, w/w), and a high-fat diet supplemented with 2% probiotics (w/w), respectively. At the end of the experimental period, that is, after 6 weeks, rats were killed. Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), contents of nitric oxide (NO) free radical and malondialdehyde (MDA) in serum and sperm suspension were examined. Sperm parameters including sperm concentration, viability, motility and DNA integrity were analyzed. The results showed that high-fat diet could induce oxidative stress, shown as significant increases in lipid peroxidation, NO free radical, significant decrease in activities of SOD, GSH-Px, significant reduction in sperm concentration, viability and motility, and damage in sperm DNA ( P , 0.05), compared with the control group. These alterations were significantly reversed in the probiotics-supplemented group and had no significant difference in antioxidant capability, lipid peroxidation and sperm parameters compared with the control group. The percentage of sperm with DNA damage was significantly lower than the high-fat diet group and still higher than the control group, which means that probiotics could attenuate sperm damage to some extent. The present results indicated that dietary probiotics had antioxidant activity and the protective effect against sperm damage induced by high-fat diet to some extent.

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Section: Discussionsupporting

confidence: 93%

Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats

Chen

Gong

2013

Animal

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“…From the results, we observed that the activity of SOD, CAT, and GPx decreased in mice fed HFD compared with those in mice fed control group (P<0.05), which is in agreement with another study (Feillet-Coudray et al, 2009). However, the administration of HFD with 0.5% COS resulted in significant increase in the activity of SOD, CAT, and GPx in stomach, liver, and serum of mice as compared with the HFD-fed group (P<0.05).…”

Section: Discussionsupporting

confidence: 92%

Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

Han

2016

R. Bras. Zootec.

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-The objective of this study was to analyze the antioxidant activities of chitooligosaccharides (COS) both in vitro and in high-fat diet (HFD)-mouse model. In antioxidant assays in HFD-mouse model, mice were administered with normal diet, HFD, or HFD with 0.5% COS for six weeks. The administration of HFD with 0.5% COS resulted in significant increase in the activity of superoxide dismutase, catalase, and glutathione peroxidase in stomach, liver, and serum of mice as compared with the HFD-fed group, which means that COS may have certain antioxidant activity and can restore the activity of the enzymes affected by the HFD. Through morphological measurements of the small intestinal mucosa, mice fed HFD showed decreased villus height compared with other groups. On the other hand, HFD with 0.5% COS group showed similar ratio of villus height to depth compared with control mice, indicating that intestinal integrity was improved when COS was added. Chitooligosaccharides have potent antioxidant activity that can protect mice from oxidative stress.

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“…According to several authors (Feillet-Coudray et al, 2009;Sour et al, 2015), changes on redox status parameters are easily detectable when dietary lipid and caloric overload occurs, or when there are some physiological disturbance, such as inflammation, obesity and dyslipidaemia. Adding pequi pulp did not increase significantly lipid content of the diet.…”

Section: Discussionmentioning

confidence: 99%

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

Moreno¹,

Oliveira²,

Melo³

et al. 2016

J. Med. Plants Res.

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Caryocar brasiliense (pequi) is an exotic fruit, high in monounsaturated fat acids (MUFA) and bioactive compounds, which have beneficial effects on cardiometabolic risk factors. However, this fruit is poorly studied in this context. In this study, the effects of pequi pulp intake on cardiometabolic risk factors of rats were evaluated. Therefore, 16 male weaned rats were divided into two groups: Control group and Pequi group. Control group was feed a standard diet and pequi group, the same diet added pequi pulp (3.26 g.100 -1 ) for 15 weeks. At the end, plasma lipids, glucose, insulin, Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR), blood pressure, heart rate, hepatic and fecal lipids and intestinal histomorphometric parameters were accessed. Liver and heart samples were harvested for redox status assays. There were no differences between experimental groups for blood pressure, heart rate, glucose, insulin, HOMA-IR, triglycerides, cholesterol, HDL-cholesterol, and liver and heart redox status (p<0.05). Pequi group had lowered lipid hepatic deposition and increased fecal output (p<0.05), increased intestinal villus height and crypt depth. Thus, pequi pulp intake minimized liver fat deposition by increasing its intestinal output and improved intestinal structure of rats, which can contribute for reducing cardiometabolic risk factors. MUFA, carotenoids and fibres can be associated, at last in part, with these effects.

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Oxidative stress in rats fed a high-fat high-sucrose diet and preventive effect of polyphenols: Involvement of mitochondrial and NAD(P)H oxidase systems

Cited by 137 publications

References 55 publications

Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats

Antioxidative activity and protective effect of probiotics against high-fat diet-induced sperm damage in rats

Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet

Caryocar brasiliense fruit intake ameliorates hepatic fat deposition and improves intestinal structure of rats

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