Oxidative Stress in Ruminants

Celi, Pietro

doi:10.1007/978-1-61779-071-3_13

Cited by 76 publications

(93 citation statements)

References 263 publications

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“…Studies in the field of veterinary medicine have shown that OS factors increase when certain diseases occur [1] . In a study conducted by Ergönül and Kontaş Aşkar [8] , the authors had the goal of identifying MDA levels in cattle with Anaplasmosis and in healthy cattle (control group).…”

Section: Discussionmentioning

confidence: 99%

“…The body consists of about 1-2% ROM, which play a role in many body activities [1] . These metabolites are found in low concentrations and play a role in functions such as protein phosphorylation, cell maturation, apoptosis, oocyte maturation, steroidogenesis, cell immunity, ovulation, implantation, blastocyst formation, luteolysis, acrosome reactions, fertilization and luteal maintenance during pregnancy [1][2][3][4] . However, when ROM is produced in large amounts in an organism, it causes damage to lipids, protein and DNA in the cell, resulting in the loss of cell functions.…”

Section: Introductionmentioning

confidence: 99%

“…However, when ROM is produced in large amounts in an organism, it causes damage to lipids, protein and DNA in the cell, resulting in the loss of cell functions. Disturbance of the balance between ROM and the antioxidant systems that eliminate these substances (such as superoxide dismutase and glutathione peroxidase) causes oxidative stress (OS) [1,2,5] .…”

Section: Introductionmentioning

confidence: 99%

“…Studies performed on cattle have reported that OS factors increase when the animals become sick [9][10][11] . Other studies have shown that the level of OS factors increases in cases of retentio secundinarum, mastitis, subclinical mastitis, udder edema, anestrus, repeat breeders, follicular cysts and metabolic diseases [1,7,[12][13][14][15] .…”

Section: Introductionmentioning

confidence: 99%

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Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi

Oral¹,

Öğün²,

Kuru³

et al. 2015

Kafkas Univ Vet Fak Derg

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The purpose of this study was to investigate the effect of short term administration of PRID on the levels of serum progesterone, nitric oxide (NO), malondialdehyde (MDA), total antioxidant capacity (TAC) and total oxidant capacity (TOC) in heifers. This purpose, 200 heifers were synchronized with the Cosynch-72 protocol in which progesterone was administered for 5 days. Blood was taken from the heifers 10 days prior to starting synchronization (day -10), the day the PRID was attached (day 0), the day the PRID was removed (day 5) and on the day of insemination (day 8). Blood taken on day -10 and day 0 were accepted as control values for the study. Serum progesterone, NO, MDA, TAC and TOC were measured on days 5 and 8. The difference in serum NO and MDA levels was found to be statistically significant on day 5 of the study (P<0.001). It was determined that the procedure caused a drop in the TAC level, while the TOC level was not affected. In conclusion, it was determined that short-term administration of PRID in heifers caused an increase in serum NO and MDA levels, a decrease in TAC level and had no effect on the TOC level. Keywords: Heifer, Nitric oxide, Oxidative Stress, PRID Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi ÖzetBu çalışmada, düvelere kısa süreli PRID uygulamasının; serum progesteron, nitrik oksit (NO), malondialdehit (MDA), total antioksidant (TAK) ve oksidant kapasitesi (TOK) düzeyleri üzerine etkisinin araştırılması amaçlanmıştır. Bu amaçla, 200 adet düve 5 gün progesteron uygulanan Cosynch-72 protokolüyle senkronize edildi. Düvelerden senkronizasyona başlamadan 10 gün önce (-10. gün), PRID takılma günü (0. gün), PRID çıkarılma günü (5. gün) ve tohumlama günü (8. gün) kan alındı. Çalışmada -10 ve 0. gün alınan kanlar kontrol olarak değerlendirildi. Beş ve 8. günlerde serum progesteron, NO, MDA, TAK ve TOK değerleri araştırıldı. Çalışmada 5. gün serum NO ve MDA düzeyleri diğer günlerden istatistiksel olarak farklı olduğu tespit edildi (P<0,001). Uygulamanın TAK düzeyinde düşmeye neden olduğu, TOK değerini ise etkilemediği belirlendi. Sonuç olarak, düvelere kısa süreli PRID uygulamasının serum NO ve MDA düzeylerinde artışa neden olduğu, TAK düzeyinde düşmeye ve TOK değerini ise etkilemediği belirlendi.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi

Oral¹,

Öğün²,

Kuru³

et al. 2015

Kafkas Univ Vet Fak Derg

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show abstract

“…Thus, the information provided in this review should be considered as an overview. Several comprehensive review papers have elucidated the deteriorative role of oxidative stress and the in vivo benefits of antioxidant nutrition in farm animals (Lykkesfeldt and Svendsen, 2007), ruminants (Miller et al, 1993a;Hansen, 2010;Celi, 2011) and poultry (Surai, 2002;Fellenberg and Speisky, 2006;Surai, 2007).…”

Section: Effects Of Supplemental Antioxidants In Livestockmentioning

confidence: 99%

Review: In vivo and postmortem effects of feed antioxidants in livestock: a review of the implications on authorization of antioxidant feed additives

Salami

Guinguina

Agboola

et al. 2016

Animal

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The pivotal roles of regulatory jurisdictions in the feed additive sector cannot be over-emphasized. In the European Union (EU), antioxidant substances are authorized as feed additives for prolonging the shelf life of feedstuffs based on their effect for preventing lipid peroxidation. However, the efficacy of antioxidants transcends their functional use as technological additives in animal feeds. Promising research results have revealed the in vivo efficacy of dietary antioxidants for combating oxidative stress in production animals. The in vivo effect of antioxidants is significant for enhancing animal health and welfare. Similarly, postmortem effect of dietary antioxidants has been demonstrated to improve the nutritional, organoleptic and shelf-life qualities of animal products. In practice, dietary antioxidants have been traditionally used by farmers for these benefits in livestock production. However, some antioxidants particularly when supplemented in excess could act as prooxidants and exert detrimental effects on animal well-being and product quality. Presently, there is no exclusive legislation in the EU to justify the authorization of antioxidant products for these in vivo and postmortem efficacy claims. To indicate these efficacy claims and appropriate dosage on product labels, it is important to broaden the authorization status of antioxidants through the appraisal of existing EU legislations on feed additives. Such regulatory review will have major impact on the legislative categorization of antioxidants and the efficacy assessment in the technical dossier application. The present review harnesses the scientific investigations of these efficacy claims in production animals and, proposes potential categorization and appraisal of in vivo methodologies for efficacy assessment of antioxidants. This review further elucidates the implication of such regulatory review on the practical application of antioxidants as feed additives in livestock production. Effecting these regulatory changes will stimulate the innovation of more potent antioxidant products and create potential new markets that will have profound economic impacts on the feed additive industry. Based on the in vivo efficacy claims, antioxidants may have to contend with the legislative controversy of either to be considered as veterinary drugs or feed additives. In this scenario, antioxidants are not intended to diagnose or cure diseases as ascribed to veterinary products. This twisted distinction can be logically debated with reference to the stipulated status of feed additives in Commission Regulation (EC) No 1831/2003. Nonetheless, it is imperative for relevant stakeholders in the feed additive industry to lobby for the review of existing EU legislations for authorization of antioxidants for these efficacy claims.

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Evaluation of thiol/disulphide and oxidant–antioxidant status of dairy cows in periparturient and post‐partum period

Balkan,

Meral,

Cetintav

et al. 2024

Veterinary Medicine & Sci

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BackgroundThiol/disulphide homeostasis (TDH) has a critical role in many cellular activities such as antioxidant protection. Alterations of oxidative stress in the transition period play an important role in development of some diseases and disorders in dairy cows.ObjectivesThe purpose of this study is to assess the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol, native thiol, disulphide and lipid profile in Simmental and Montofon dairy cows (aged 2–3) before and after calving.MethodsBlood samples were collected 233–280 days of pregnancy and the 30 days of post‐partum. Serum total thiol, native thiol and disulphide levels were determined as well as TAS, TOS and paraoxonase‐1 (PON‐1) levels were measured using colorimetric assays. Triglycerides (TG), total cholesterol, HDL cholesterol and LDL cholesterol levels were measured with an automatic analyser.ResultsTotal thiol (p = 0.038) and disulphide (p = 0.015) levels were higher after calving compare to pregnancy in Montofon. TAS was found lower (p < 0.001), and OSI was higher in both breeds (Montofon p = 0.012, Simmental p = 0.028) after calving than in pregnancy. When compared between pregnancy and after calving levels in the same breed, HDL was found to be higher after calving (p < 0.001) and TG was lower after calving (p = 0.020) in Montofon. PON (p = 0.090), HDL (p < 0.001) and cholesterol levels were found higher (p < 0.001) and TG level was lower (p < 0.001) after calving in Simmental.ConclusionsAccording to our results, we observed different responses between two breeds before and after calving. There are few studies about TDH in animal research, and this is the first study in the literature that evaluates the TDH along with oxidative stress and lipid profiles in dairy cows in the periparturient and post‐partum period.

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Oxidative Stress in Ruminants

Cited by 76 publications

References 263 publications

Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi

Kısa Süreli PRID Uygulanan Düvelerde Bazı Oksidatif Stres Parametrelerinin Değerlendirilmesi

Review: In vivo and postmortem effects of feed antioxidants in livestock: a review of the implications on authorization of antioxidant feed additives

Evaluation of thiol/disulphide and oxidant–antioxidant status of dairy cows in periparturient and post‐partum period

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