Oxidative Stress Incidence on the Severity of Knee Osteoarthritis

Abstract

The aim of the study was to examine the incidence of oxidative stress on the severity of knee osteoarthritis (OA). Data were obtained from a previous pilot controlled trial among patients, diagnosed with OA in one or both knees, that were randomly assigned into two different treatment groups and were either supplemented with ascorbic acid and Vitamin E daily per os or treated with meloxicam. The following markers were estimated: A. Clinical markers: functionality of the knee (WOMAC index), pain (using a pain visual analogue scale) and severity of OA (Kellgren–Lawrence grading scale) B. Laboratory markers: total antioxidant capacity (TAC) and malonyldialdehyde (MDA) levels in the synovial fluid. The TAC of the knees was moderately correlated with the severity of OA and the level of pain whilst MDA concentration was weekly correlated. An average change of 5[Formula: see text]mM of a-tocopherol in TAC (4.6–5.5[Formula: see text]mM of a-tocopherol) defines the shift among stages of OA and the level of pain experienced by the patients. Neither TAC nor MDA were correlated with the Kellgren–Lawrence grading scale. Alleviation of oxidative stress should be a key objective for the therapeutic interventions (pharmacological and nonpharmacological) in knee OA. Even small improvements in antioxidant capacity of the synovial fluid may contribute to the patient’s quality of life and to the deceleration of the disease progression.

Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis

“…Although, the cellular antioxidant system of cells is activated; an imbalance appears because of the excessive ROS in damaged tissue [ 25 ]. In the knee joint, the presence of excessive ROS leads to chondrocyte matrix destruction, senescence and apoptosis of chondrocytes [ 26 ]. It appears that the damage to chondrocytes can be diminished by reducing ROS [ 27 ].…”

The Role of Vitamin E in Preventing and Treating Osteoarthritis – A Review of the Current Evidence

“…However, this study was limited by its small sample size ( n = 56) and relatively young subjects (mean age = 48 ± 1 years). Using data from a clinical trial, Oikonomidis et al (2017) performed secondary analysis among osteoarthritic patients administered with vitamin C and vitamin E or meloxicam ( Oikonomidis et al, 2017 ). A negative relationship was observed between synovial alpha-tocopherol and malondialdehyde ratio with Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and pain visual analogs scale ( Oikonomidis et al, 2017 ).…”

“…Using data from a clinical trial, Oikonomidis et al (2017) performed secondary analysis among osteoarthritic patients administered with vitamin C and vitamin E or meloxicam ( Oikonomidis et al, 2017 ). A negative relationship was observed between synovial alpha-tocopherol and malondialdehyde ratio with Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and pain visual analogs scale ( Oikonomidis et al, 2017 ). A shift of approximately 5 mM total antioxidant capacity (TAC) expressed as a-tocopherol equivalents was demonstrated to change the degree of osteoarthritis and pain ( Oikonomidis et al, 2017 ).…”

“…A negative relationship was observed between synovial alpha-tocopherol and malondialdehyde ratio with Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and pain visual analogs scale ( Oikonomidis et al, 2017 ). A shift of approximately 5 mM total antioxidant capacity (TAC) expressed as a-tocopherol equivalents was demonstrated to change the degree of osteoarthritis and pain ( Oikonomidis et al, 2017 ). However, there was no significant association between alpha-tocopherol and Kellgren–Lawrence grade ( Oikonomidis et al, 2017 ).…”

“…A shift of approximately 5 mM total antioxidant capacity (TAC) expressed as a-tocopherol equivalents was demonstrated to change the degree of osteoarthritis and pain ( Oikonomidis et al, 2017 ). However, there was no significant association between alpha-tocopherol and Kellgren–Lawrence grade ( Oikonomidis et al, 2017 ).…”