Oxidative Stress Increased in Pregnant Women with Iodine Deficiency

Vidal, Zendy Evelyn Olivo; Rufino, Sergio Cuellar; Tlaxcalteco, Esteban Hernández; Trejo, Cirenia Hernández; Campos, Raul Martinez; Meza, Mónica Navarro; Rodríguez, Roció Coutiño; Arroyo-Helguera, Omar

doi:10.1007/s12011-014-9898-6

Cited by 35 publications

(29 citation statements)

References 27 publications

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“…This increase has been associated with various diseases such as cancer, atherosclerosis and preeclampsia (PE), among others (33)(34)(35). Imbalance between antioxidant defenses and lipid peroxidation leads to endothelial dysfunction and cell damage mediated by free radicals, altering trophoblast differentiation processes and migration to the uterine spiral arteries, and causing poor placentation and, consequently, pregnancy hypertensive disease (5,36,37). In pregnant women with preeclampsia, high levels of oxidative stress and low antioxidant status were found (38).…”

Section: Discussionmentioning

confidence: 99%

“…Five milliliters of fasting venous blood were collected in BD Vacutainer ® and preserved using packs of ice blocks; later, they were transported to the laboratory for the assessment of TBARS level, an indicator of oxidative stress. SOD, catalase, and total antioxidant status (TAS) were measured as indicators of antioxidant status as previously reported (5). The blood samples were centrifuged at 5,000 rpm for five minutes to separate plasma.…”

Section: Patientsmentioning

confidence: 99%

“…Urinary iodine concentration (UIC) was measured using a fast colorimetric method, appropriate for population studies (5,15). Briefly, 0.2 ml of serum or iodine calibrator (50-300 μg/l) and 1.0 ml of ammonium persulfate solution were heated for one hour at 100 °C.…”

Section: Urinary Iodine Concentration Tsh and Free T4 Determinationsmentioning

confidence: 99%

“…Although there have been great advances in medicine, the frequency of this disease has not been successfully modified significantly (3). Currently, the etiology of this disease remains unknown, therefore, in order to explain its origin various theories have been raised, and within each of them the genetic origin, immune factor, endothelial dysfunction, increased oxidative stress, micronutrients deficiency, among others, can be mentioned (3)(4)(5)(6)(7)(8). During pregnancy, there is a normal increase in the production of reactive oxygen species (ROS); likewise, the antioxidant capacity is increased.…”

Section: Introductionmentioning

confidence: 99%

“…While in an indirect way iodine can be iodinated fatty acids derived from arachidonic acid and join a superfamily of known nuclear receptors as receptors activators peroxisomal proliferation (PPAR), which have the function of acting as transcription factors that regulate antioxidant genes activation (24)(25)(26). Iodine deficiency may be involved in the alteration of the antioxidant balance, and thus increase levels of oxidative stress, causing the development of complications during pregnancy and hypertensive disorders (5). This study aimed to establish the association between iodine levels in urine, antioxidant status and oxidative stress and women diagnosed with hypertensive disorder of pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

et al. 2017

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Background: Previously has been reported the antioxidant function of iodine, and iodine deficiency as a risk factor of preeclampsia.Aim: We analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD).Method: 57 pregnant women were recruited in the last trimester of pregnancy, 20 diagnosed with hypertensive disease of pregnancy and 37 normotensive pregnant women. Urinary iodine concentration (UIC), TSH, free T4 (fT4), total antioxidant status (FRP), Superoxide dismutase (SOD), Catalase (CAT), and oxidative stress (TBARS) were evaluated by colorimetric methods.Results: UIC median for all pregnant women was of 151.9 µg / L. The UIC median for pregnant women with HPD was between 50-149 µg/L compared to 150-249 µg/L in normotensive women. No significant changes were found in levels of TSH and fT4 in normotensive pregnant compared with HPD women. Pregnant women with HPD had significant high levels of TBARS, and significant low levels of FRP, SOD, CAT and UIC compared to normotensive pregnant. In addition, pregnant women with optimal levels of UIC had a higher SOD activity (R = 0.354, P = 0.011), while iodine deficiency was associated with HPD (R = -0,281, p = 0.039). Similarly, pregnant with HPD had a significant negative association with SOD activity (R = -0,702, p = 0.005), CAT (R = -0,409, p = 0.002), and FRP (R = -0,624, p = 0.003), and a positive association with TBARS (R = 0.744, p = 0.001).Conclusion: iodine contributes to REDOX balance during pregnancy; its deficiency is associated with HPD. This study shows the importance of iodine during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Urinary Iodine Concentration Tsh and Free T4 Determinationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

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Iodine Affects Differentiation and Migration Process in Trophoblastic Cells

Vidal

Rodríguez

Arroyo-Helguera

2015

Biol Trace Elem Res

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Iodine deficiency is associated with oxidative stress increase and preeclampsia during gestation, suggesting that iodine concentration plays an important role in the normal placenta physiology. The question raised is to analyze the effect of iodine deficiency on oxidative stress, viability, differentiation, and migration process and changes in the expression of differentiation and migration markers. Iodine deprivation was done using potassium perchlorate (KCLO4) to block sodium iodide symporter (NIS) transporter and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid DIDS to inhibit pendrine (PEN) transport for 3-48 h. Then trophoblast cells were treated with low iodine doses of 5-500 μM and high iodine doses of 100-5000 μM. Oxidative stress, viability, and human chorionic gonadotropin (hGC) were measured by colorimetric methods. Migration throphoblast cells were evaluated by both wound healing and Boyden chamber assays. Changes in mRNA expression were analyzed by real-time RT-PCR. Iodine deprivation induces a significant increase of reactive oxygen species (ROS), viability, and migration process vs control cells. We found a significant overregulation in the mRNA's peroxisome proliferator-activated receptor (PPAR-gamma), Snail, and matrix metalloproteinase-9 (MMP-9) mRNA's in cells deprived of iodine, as well as a down glial cell missing-1 (GCM-1) regulation, hGC, pregnancy-associated plasma protein-A (PAPP-A), and E-cadherin mRNA expression. The expression of hypoxic induction factor alpha (HIFα) mRNA does not change with iodine deprivation. In cells deprived of iodine, supplementing low iodine doses (5-500 μM) does not induce any significant changes in viability. However, ROS and migration process were decreased, although we found an increased human chorionic gonadotropin (hCG) secretion as a differentiation marker. In addition, we found that PPAR-gamma, Snail, and MPP-9 mRNAs expression are downregulated with low iodine doses, in contrast with GCM-1, PAPP-A, hGC, and E-cadherin that increase their expression vs cells deprived of iodine. High iodine doses (1000-5000 μM) have shown cytotoxic effects. Based on our results, iodine is important for keeping the proliferation/differentiation balance in the placenta.

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Dietary Iodine Affected the GSH-Px to Regulate the Thyroid Hormones in Thyroid Gland of Rex Rabbits

Qin

Pan

Yang

et al. 2017

Biol Trace Elem Res

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Iodine (I) is an essential trace element that can influence animal health and productivity. In this study, we investigated the effects of dietary iodine on the antioxidant indices of organ (liver and thyroid gland) and messenger RNA (mRNA) expression of glutathione peroxidase (GSH-Px) in Rex rabbits. A total of 120 4-month-old Rex rabbits (2235.4 ± 13.04 g BW) were divided into four equal groups, and their diets were supplemented with iodine (0, 0.2, 2, or 4 mg/kg dry matter (DM)). The iodine concentration in basal diet (control group) was 0.36 mg/kg DM. In most of measured parameters, supplemental iodine exerted no significant effect. Growth and slaughter performance and organ weight were not influenced significantly by iodine supplementation. Serum T was significantly lower in 2-mg I group than in 0.2 and 4-mg I groups (P < 0.05). Superoxide dismutase (SOD), GSH-Px, methane dicarboxylic aldehyde (MDA), and thyroperoxidase (TPO) in the serum and liver were not influenced (P > 0.05). Conversely, serum catalase (CAT) was significantly reduced (P < 0.05). In the thyroid, GSH-Px was higher in the 2-mg I group than in the 0.2- and 4-mg I groups (P < 0.05). RT-PCR results showed that the mRNA expression level of GSH-Px in the liver was not significantly influenced (P > 0.05). In the thyroid gland, the mRNA expression level of GSH-Px was higher in the 2-mg I group than in the 4-mg I group (P < 0.05), which agreed with the activity of GSH-Px. In conclusion, iodine supplementation exerted no effect on the performance and antioxidant capacity of the body, but dietary iodine influenced serum T or GSH-Px in the thyroid gland. Thus, on the basis of serum T and GSH-Px levels in the thyroid gland, we hypothesized that GSH-Px secretion was increased by adding dietary iodine in the thyroid, which may inhibit the HO generation and further influence the thyroid hormone synthesis.

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Oxidative Stress Increased in Pregnant Women with Iodine Deficiency

Cited by 35 publications

References 27 publications

Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

Iodine levels are associated with oxidative stress and antioxidant status in pregnant women with hypertensive disease

Iodine Affects Differentiation and Migration Process in Trophoblastic Cells

Dietary Iodine Affected the GSH-Px to Regulate the Thyroid Hormones in Thyroid Gland of Rex Rabbits

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