Oxidative stress index may play a key role in patients with pemphigus vulgaris

Yeşilova, Yavuz; Uçmak, Derya; Selek, Sahabettın; Dertlioğlu, Selma Bakar; Sula, Bilal; Bozkus, Ferhat; Turan, Enver

doi:10.1111/j.1468-3083.2012.04463.x

Cited by 46 publications

(34 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our focus on mitochondrial targets of PV autoimmunity stems from classic and modern studies placing mitochondrial damage within the pathophysiological loop. The mitochondrial dysfunction in the lesional skin of PV patients had been suggested by an increase of lipid peroxidation and peroxidant-antioxidant balance, reflecting an increased production of reactive oxygen species (ROS) (10,11) and measuring oxidative stress (12), respectively; abnormal activities of the mitochondrial enzymes oxidoreductase, adenosine triphosphatase, and NADH 2 -cytochrome c reductase (13)(14)(15); and skewed balance between oxybiotic and anoxybiotic metabolism toward the latter (15).…”

Section: Pemphigus Vulgaris (Pv)mentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Previous studies suggested that mitochondrial antibodies contribute to pemphigus vulgaris (PV). Results: PV sera elicited mitochondrial damage, and mitochondria-protecting drugs exhibited protective effect in cell culture and mouse skin. Conclusion: PV antibodies altered O 2 respiration, disrupted electron transfer chain, and increased reactive oxygen species. Significance: Results provide the mechanism of therapeutic action and justify the use of mitochondria-protecting drugs in PV.

show abstract

Section: Pemphigus Vulgaris (Pv)mentioning

confidence: 99%

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Kalantari-Dehaghi

Chen²,

Deng³

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…To name a few, other neutrophil-related dermatosis are arsenic-induced skin lesions (Pei et al, 2013), pemphigus vulgaris (Yesilova et al, 2013), and psoriasis (Rocha-Pereira et al, 2004). Importantly, the overproduction of ROS by activated neutrophils may cause damage in skin proteins, lipids, and DNA.…”

Section: Resultsmentioning

confidence: 99%

Stem bark and flower extracts ofVismia caulifloraare highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes

Ribeiro

Berto

Ribeiro

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

(2015) Stem bark and flower extracts of Vismiacauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes, Pharmaceutical Biology, 53:11, 1691-1698, DOI: 10.3109/13880209.2014 Previous research on V. cauliflora extracts suggests its potential to neutralize cellular oxidative damages related to the production of reactive oxygen and nitrogen species.Objective: To determine the activity of stem bark and flower extracts of V. cauliflora on the modulation of oxidative burst in human neutrophils, as well as its potential to inhibit oxidative damage in human erythrocytes. Materials and methods:The modulation of neutrophil's oxidative burst by the ethanolic extracts (0.3-1000 mg/mL) was determined by the oxidation of specific probes by reactive species. Additionally, the potential of these extracts to inhibit oxidative damage in human erythrocytes was evaluated by monitoring its biomarkers of oxidative stress. Results: Vismia cauliflora extracts presented remarkable capacity to prevent the oxidative burst in activated human neutrophils (IC 50 515 mg/mL). However, the maximum percentage of inhibition achieved against hydrogen peroxide was 45%. Concerning the oxidative damage in human erythrocytes, the extracts were able to minimize the tert-butyl hydroperoxide-induced hemoglobin oxidation and lipid peroxidation in a very low concentration range (2.7-18 mg/mL). Furthermore, only stem bark extract (100 mg/mL) was able to inhibit the depletion of glutathione (13%). Discussion and conclusion: These results reinforce the therapeutic potential of stem bark and flower extracts of V. cauliflora to heal topical skin disease, namely in the treatment of neutrophil-related dermatosis and skin conditions related to oxidative stress, including skin aging.

show abstract

“…This is particularly important since there is overwhelming evidence that chronic periodontitis induces a state of systemic inflammation 42. Additionally, impaired redox balance is involved in many inflammatory disorders that have oral manifestations, such as lichen planus and pemphigus vulgaris 43,44. Acrolein changes the redox state of cells by triggering ROS formation or acts as an oxidant in a variety of cells, for instance in retinal cells, bronchial epithelial cells, as well as T cells 45–47.…”

Section: The Role Of Acrolein In the Pathogenesis Of Oral Injuriesmentioning

confidence: 99%

Acrolein—an α,ß-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects

Aizenbud¹,

Aizenbud²,

Reznick³

et al. 2016

Rambam Maimonides Med J

View full text Add to dashboard Cite

Acrolein is a highly reactive unsaturated aldehyde widely present in the environment, particularly as a product of tobacco smoke. Our previous studies indicated the adverse consequences of even short-term acrolein exposure and proposed a molecular mechanism of its potential harmful effect on oral cavity keratinocytic cells. In this paper we chose to review the broad spectrum of acrolein sources such as pollution, food, and smoking. Consequently, in this paper we consider a high level of oral exposure to acrolein through these sources and discuss the noxious effects it has on the oral cavity including on salivary quality and contents, oral resistance to oxidative stress, and stress mechanism activation in a variety of oral cells.

show abstract

Oxidative stress index may play a key role in patients with pemphigus vulgaris

Abstract: Serum TOC and LOOH levels and OSI were higher in the PV patients, in comparison with the control group. Serum TAC level was not different.

Cited by 46 publications

References 16 publications

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies

Stem bark and flower extracts ofVismia caulifloraare highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes

Acrolein—an α,ß-Unsaturated Aldehyde: A Review of Oral Cavity Exposure and Oral Pathology Effects

Contact Info

Product

Resources

About