Oxidative Stress Markers in Children With End Stage Kidney Disease

El-Shafei, Ali M; El-Mashad, Ghada M; Azzam, Ahmad

doi:10.15401/jcpn/2014/v2i2/66344

Cited by 1 publication

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“…Zwołińska (2006) study on 21 hemodialysis pediatric patients found that SOD was significantly decreased [15] which is in agreement with our study. Similar to our study, SOD activity was significantly lower in hemodialysis patients whatever children or adults [16], [17], [18], https://www.id-press.eu/mjms/index [19], [20], [21], [22]. In contrast to our study, activity of SOD has been increased in few studies which were explained by invoking adaptation to the increased rate of oxidation [23], [24], [25].…”

Section: Discussionsupporting

confidence: 79%

Oxidative Stress in Hemodialysis Pediatric Patients

Shouman

Sabry

Galal

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Oxidative stress may play a role in complications of hemodialysis patients as atherosclerosis, thrombosis, and inflammation. AIM: The aim of the study was to evaluate the oxidative stress in hemodialysis pediatric patients through measurement of oxidative stress enzymes as paraoxanase activity (PON), arylesterase activity (ASA), superoxide dismutase (SOD) and also non-enzymatic antioxidant vitamins as vitamins A, C and E levels. METHODS: The study included 50 hemodialysis pediatric patients with mean age 11.4 ± 5.4 years and 30 normal children of matched sex and age as a control group. Assessment of oxidative stresses was done using ELIZA technique. RESULTS: SOD, ASA, and vitamin C were significantly lower among hemodialysis patients in comparison to control group (p = 0.004, 0.004, > 0.001 respectively). CONCLUSION: The study concluded that oxidative stress was common finding in hemodialysis pediatric patients which may play a role in complications encountered among these patients.

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