Oxidative Stress Markers in Hypertrophic Cardiomyopathy

Abstract

Background and Objectives: Hypertrophic cardiomyopathy (HCM) depends on the primary impairment of sarcomeres, but it can also be associated with secondary alterations in the heart related to oxidative stress. The present study aimed to examine oxidative-antioxidant disturbances in patients with HCM compared with control individuals. Materials and Methods: We enrolled 52 consecutive HCM patients and 97 controls without HCM. The groups were matched for age, body mass index, and sex. Peripheral blood was collected from all patients to determine the total antioxidant capacity (TAC), total oxidant status (TOS), lipid hydroperoxide (LPH), and malondialdehyde (MDA). The oxidative stress index (OSI) was defined as the ratio of the TOS level to the TAC level. Results: The median age was 52 years, and 58.4% were female. The area under the curve (AUC) indicated good predictive power for the TAC and TOS [AUC 0.77 (0.69–0.84) and 0.83 (0.76–0.90), respectively], as well as excellent predictive power for the OSI [AUC 0.87 (0.81–0.93)] for HCM detection. Lipid peroxidation markers also demonstrated good predictive power to detect HCM patients [AUCLPH = 0.73, AUCMDA = 0.79]. Conclusions: The TOS, the TAC, LPH levels, and MDA levels have good predictive power for HCM detection. The holistic assessment of oxidative stress by the OSI had excellent power and could identify patients with HCM.

Gender Related Differences in the Clinical Presentation of Hypertrophic Cardiomyopathy—An Analysis from the SILICOFCM Database

“…Advanced stages of non-obstructive HCM can be and are mostly associated with increased myocardial fibrosis, microvascular ischemia, and abnormal cardiac function [8]. Novel findings suggest that HCM is associated with an increased oxidative stress and that markers of oxidative stress could even be used to identify patients with HCM [9].…”

Monoamine Oxidase (MAO) Is Expressed at the Level of Mitral Valve with Severe Regurgitation in Hypertrophic Obstructive Cardiomyopathy: A Case Report

“…Among these, in a pioneering study Dimitrow et al reported the occurrence of increased oxidative stress in patients with HCM evidenced by increased serum levels of 8-isoprostaglandin F(2alpha), which was the highest in the subgroup of HCM patients with LVOT obstruction [23]. More recently, Szygula-Jurkiewicz et al evaluated the total oxidative-antioxidant balance in patients with HCM and showed that patients with HCM had prooxidative changes with predictive value as compared to controls [24].…”

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

“…Increased cytosolic ADP increases the oxidation of two metabolic enzymes (NADH and NADPH), which decreases the capacity to attenuate mitochondrial reactive oxygen species (ROS) levels, as NADPH is necessary to detoxify ROS ( 30 ). Increased ROS subsequently impairs mitochondrial activation and contributes to HCM development ( 33 ). Additionally, reduced phosphocreatine (PCr)/ATP ratios in HCM, both with and without hypertrophy, indicate cardiac energetic impairments are present at an early stage of HCM ( 34 ).…”