Oxidative stress markers in infectious respiratory diseases: current clinical practice

Bwititi, Phillip; Chinkwo, Kenneth A.

doi:10.18203/2320-6012.ijrms20161727

Cited by 4 publications

(3 citation statements)

References 88 publications

(155 reference statements)

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“…Given the increase of oxidative stress (18)(19)(20) and inflammatory cytokines in respiratory diseases (21,22) and the high prevalence of ARI in children, we sought for the first time to investigate the effects of Gln supplementation on serum levels of tumor necrosis factor α (TNF-α), interleukin 1 beta (IL-1β), high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and total antioxidant capacity (TAC) in hospitalized children with ARI.…”

Section: Introductionmentioning

confidence: 99%

Glutamine Supplementation Reduced Fasting Levels of High-Sensitivity C-Reactive Protein in Hospitalized Children with Acute Respiratory Infection: A Randomized Controlled Trial

et al. 2022

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Background: Glutamine (Gln), as a precursor of glutathione and attenuation of pro-inflammatory cytokines, has a vital role in the antioxidant and anti-inflammatory defense of the body. Oxidative stress and inflammatory cytokines increase in respiratory diseases. Objectives: We sought to investigate the effect of Gln supplementation on serum levels of some inflammatory and oxidative stress indices in hospitalized children with ARI. Methods: We conducted a 5-day parallel-group, randomized controlled trial. This clinical trial was held for 5 days to assess the efficacy of the 0.5 g/kg body weight Gln, along with medical therapy, in hospitalized children with ARI. Results: The difference in the high-sensitivity C-reactive protein (hs-CRP) between the Gln and placebo groups was significant after the intervention (analyzed by analysis of covariance [ANCOVA] after adjusting for the duration of cough and biochemical baseline values, 10.67 [7.77] vs 14.04 [6.57], respectively; P = 0.005). Moreover, at the end of the trial, there was no significant difference regarding the duration of hospitalization between the Gln and placebo groups (3.25 [1.37] vs 3.35 [0.8], respectively; P = 0.70). Conclusions: The effect of Gln supplementation on the reduction of hs-CRP in children with ARI was demonstrated in this study. Further research is needed to determine the exact effect of Gln on inflammatory and oxidative stress biomarkers in children with ARI.

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Section: Introductionmentioning

confidence: 99%

Glutamine Supplementation Reduced Fasting Levels of High-Sensitivity C-Reactive Protein in Hospitalized Children with Acute Respiratory Infection: A Randomized Controlled Trial

et al. 2022

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“…These changes correlate with the disease severity. Excessive accumulation of lipid peroxidation products in patients with an infection profile leads to a protracted course of the disease and the development of various complications [8,9]. However, there are still gaps in the study and determination of the contribution to the pathogenesis of chickenpox of lipid peroxidation and the antioxidant system.…”

Section: Introductionmentioning

confidence: 99%

Free radical damage: role in varicella zoster virus infection

et al. 2021

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Study of the role of lipid peroxidation and antioxidant system in patients with infectious diseases is of great interest to researchers. Numerous studies have led to a common understanding of their contribution to the pathogenesis of infectious diseases, as well as to the complications development. However, the state of lipid peroxidation and antioxidant protection in patients with chickenpox (varicella) has not been sufficiently studied which is important for the development of new targeted treatments. The aim of the research - to assess the state of lipid peroxidation (LPO) and the antioxidant system (AOS) in the dynamics in patients with chickenpox, depending on the severity of the disease. Materials and methods. We selected for participating in the study 240 chickenpox patients (142 women and 98 men) aged 18-40 years. Chickenpox was diagnosed using clinical, serological, and molecular genetic methods. The state assessment of LPO in chickenpox patients was based on the determination of serum diene conjugates (DC), malondialdehyde (MDA) levels and the total oxidative activity (TOA) of blood plasma. Results. Study showed that the process of lipid peroxidation increases and the activity of the antioxidant system decreases in patients with chickenpox during the acute period of the disease. The extent of these processes becomes greater as the severity of chickenpox increases. A decrease in the activity of antioxidant enzymes and a disruption in the functioning of the glutathione system in patients with moderate to severe hypertension leads to disruption of protective mechanisms and, as a result, to an increase in the free radical chain reactions, the uncontrolled growth of which causes irreversible damage to the membranes of various cells, which underlies visceropathy in chickenpox patients. Conclusions. Antioxidant system is activated in the acute period in patients with mild chickenpox. It is evidenced by an increase in the overall antioxidant activity of blood plasma (p=0.045) and red blood cells (p=0.00087), in the activity of catalase (p=0.001), superoxide dismutase (p=0.0093), glutathione peroxidase (p=0.036), glutathione reductase of plasma and red blood cells, and an increase in the concentration of oxidized and reduced glutathione in blood. Lipid peroxidation is hyperactivated in the acute period in patients with a moderate and severe course of the disease and an excess amount of primary and secondary hydroperoxides of fatty acids accumulates in the blood. This is accompanied by indicates a developing imbalance between the oxidative and antioxidant systems in group of patients with moderate and severe chickenpox. Our findings confirm the usefulness of antioxidants in the treatment of chickenpox.

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“…Таким образом, кроме непосредственного раздражающего воздействия на респираторный тракт, взвешенные микрочастицы вызывают окислительный стресс [11,21]. В работах зарубежных и отечественных авторов доказана важная роль окислительного стресса в патогенезе самых различных респираторных заболеваний, включая хроническую обструктивную болезнь легких, бронхиальную астму, острые респираторные инфекции, рак легких [7,8,19,56]. Окислительный стресс способствует возникновению и развитию воспалительных процессов в тканях и органах как дыхательной, так и сердечно-сосудистой и других систем, приводит к эпигенетическим изменениям в клетках [9].…”

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Regulation by thiol disulfide and antioxidant systems of oxidative stress induced by atmospheric suspended particles

Barskova

Виткина

2019

Bûlletenʹ fiziologii i patologii dyhaniâ

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Владивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания»-Научно-исследовательский институт медицинской климатологии и восстановительного лечения, 690105, г. Владивосток, ул. Русская 73г Контактная информация Людмила Сергеевна Барскова, аспирант, младший научный сотрудник, лаборатория медицинской экологии и рекреационных ресурсов, Владивостокский филиал Федерального государственного бюджетного научного учреждения «Дальневосточный научный центр физиологии и патологии дыхания»-Научно-исследовательский институт медицинской климатологии и восстановительного лечения, 690105, Россия, г. Владивосток, ул. Русская, 73г.

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Oxidative stress markers in infectious respiratory diseases: current clinical practice

Cited by 4 publications

References 88 publications

Glutamine Supplementation Reduced Fasting Levels of High-Sensitivity C-Reactive Protein in Hospitalized Children with Acute Respiratory Infection: A Randomized Controlled Trial

Glutamine Supplementation Reduced Fasting Levels of High-Sensitivity C-Reactive Protein in Hospitalized Children with Acute Respiratory Infection: A Randomized Controlled Trial

Free radical damage: role in varicella zoster virus infection

Regulation by thiol disulfide and antioxidant systems of oxidative stress induced by atmospheric suspended particles

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