Oxidative stress-mediated mitochondrial pathway-dependent apoptosis is induced by silica nanoparticles in <i>H9c2</i> cardiomyocytes

Cui, Guanqun; Zhang, Haiyang; Guo, Qiming; Shan, Shan; Chen, Shangya; Li, Chao; Xu, Yang; Li, Ziyuan; Mu, Yingwen; Shao, Hua; Du, Zhongjun

doi:10.1080/15376516.2020.1805664

Cited by 12 publications

(4 citation statements)

References 39 publications

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“…Therefore, the suppression of lysosomal proteolysis results in an accumulation of un-degraded vesicles, which leads to increased ROS production and CMs death. 48,52,55 Another pathway that causes DOX-induced cardiotoxic effects is known as ferroptosis. 43 It is characterized by the build-up of iron lipid peroxides, a signicant source of ROS.…”

Section: Discussionmentioning

confidence: 99%

“…50,51 Patients prescribed DOX are at potential risk of its asymptomatic cardiotoxic side effects, such as elevated stress in the le ventricular wall leading to arrhythmias, heart failure to heart transplantation. 48,55 The principal proposed mechanism of doxorubicin-induced cardiotoxicity is increased oxidative stress. The generation of ROS is the general route by which doxorubicin harms the myocardium.…”

Section: Discussionmentioning

confidence: 99%

“…6). While Tiron is a vitamin E analog and NAC is a non-toxic glutathione precursor, both are considered antioxidants that help protect cells from the damage caused by free radicals, 47,48 therefore in this experiment only NAC-supplementation was studied. Experimental samples included CMs exposed to varying doses of only NAC (1, 8, and 15 mM; Fig.…”

Section: Flow Cytometric-based Cell Proliferation Analysis On Cmsmentioning

confidence: 99%

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Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Flow Cytometric-based Cell Proliferation Analysis On Cmsmentioning

confidence: 99%

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Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system

et al. 2023

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“…Therefore, the increase in the level of ROS in mitochondria is involved in nanoparticle toxicity. [ 42–44 ] Results indicated that inhalation exposure to MWCNTs increased the level of ROS in rat kidney mitochondria. Previous studies also have shown that CNTs can increase the level of ROS.…”

Section: Discussionmentioning

confidence: 99%

Apigenin ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria

Zamani

Samiei

Mousavi

et al. 2021

J Biochem & Molecular Tox

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The toxicity of carbon nanotubes (CNTs) toward the mitochondria of the kidney is not fully recognized and still needs further research. Apigenin (APG) is known as a flavonoid compound and natural antioxidant. The purpose of this study was to assess the ameliorative role of APG against multiwall CNT (MWCNT)-induced kidney toxicity in rats. The animals were administrated with APG (10 mg/kg) for 2 weeks and then were exposed to MWCNTs (5 mg/m 3 ) in pure and impure forms (10 and 100 nm) for 5 h/day and 5 days/week. Then, mitochondria were isolated from the kidney tissue and mitochondrial toxicity parameters were measured. Decreases in succinate dehydrogenase activity have been reported in all groups exposed to MWCNTs. Results indicated that MWCNTs in both forms and sizes were able to increase the generation of reactive oxygen species, decline mitochondrial membrane potential, induce mitochondrial swelling, and release cytochrome c in isolated kidney mitochondria. The pretreatment of APG decreased all the abovementioned mitochondrial damage and oxidative stress parameters induced by both pure and impure MWCNTs. Our results showed that MWCNTs have the ability to enter the body, subsequently, cross cellular barriers, and reach the kidney as a sensitive organ, which can result in mitochondrial damage in kidney cells including renal tubular cells. In addition, APG can be an effective nutritional antioxidant regimen against MWCNT-induced kidney damage.

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Cytotoxic effect of silica nanoparticles on human retinal pigment epithelial cells

Kaynar

Çömelekoğlu

Kibar

et al. 2023

Biochemical and Biophysical Research Communications

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Oxidative stress-mediated mitochondrial pathway-dependent apoptosis is induced by silica nanoparticles in H9c2 cardiomyocytes

Cited by 12 publications

References 39 publications

Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system

Demonstration of doxorubicin's cardiotoxicity and screening using a 3D bioprinted spheroidal droplet-based system

Apigenin ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria

Cytotoxic effect of silica nanoparticles on human retinal pigment epithelial cells

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