Oxidative Stress Pathway Driven by Inflammation in Gastric Mucosa

Dovhanj, Jasna; Švagelj, Dražen

doi:10.5772/23875

Cited by 5 publications

(3 citation statements)

References 80 publications

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“…In the gastrointestinal (GI) tract, NO has a dual function at the gastric mucosal level [26]. One of these functions is the endothelial nitric oxide synthase (eNOS) that produces NO to assist in gastric ulcer healing mainly through stimulation of the vascular integrity and mucus production, increasing the blood flow, and anti-inflammatory action [27], while excessive NO generated from inducible nitric oxide synthase (iNOS) was involved in the tissue damage via the formation of ROS and the toxic effects on cells [28]. Maintaining normal levels of NO is very important in stomach health as this inhibits neutrophil infiltration and helps blood circulation as a vasodilator in the stomach [26].…”

Section: Discussionmentioning

confidence: 99%

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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

et al. 2020

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Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-κb1, tumor necrosis factor-α, interferon γ, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-κB signaling pathway-related protein markers inhibitor of κB (IκB)-α, IκB kinase, and NF-κB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa.

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Section: Discussionmentioning

confidence: 99%

“…Acute gastritis is closely associated with oxidative stress and inflammation, including neutrophil infiltration [27]. Excessive oxidative stress causes excess cellular levels of ROS.…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats

et al. 2020

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“…Oxidative stress (OS) is a condition that is characterized by an imbalance between pro-oxidant processes induced by reactive oxygen species (ROS) and the capacity of the antioxidant protection of organisms to prevent their excess production or overcome the consequences of their action. Much data has shown that increased ROS formation is not only a trigger of inflammation, but the inflammation itself provokes ROS production in gastric disorders [ 12 , 13 ]. In addition, peptic ulcers and other phenotypes of gastrointestinal diseases (e.g., gastroparesis) are known to be related to antioxidant property dysfunction [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Snail Mucus Protective Effect on Ethanol-Induced Gastric Ulcers in Mice

Petrov

Kachaunov

Alexandrova

et al. 2022

Life

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Nowadays, an increased interest in natural compounds with preventive or therapeutic potential for various diseases has been observed. Given the involvement of oxidative stress in the pathogenesis of gastric ulcer (GU) and the wide range of bioactive compounds isolated from snails, this study aimed to investigate the protective effect of Cornu aspersum (Müller, 1774) mucus on ethanol-induced GUs. Male albino mice were divided into Control, Ethanol, Mucus + Ethanol and Mucus + Omeprazole treated groups. The GUs were induced by administration of 96% ethanol (10 mL/kg, per os). One hour before ulcer induction, the mice of Mucus + Ethanol group were pretreated with mucus (20 mg/kg, per os), and the mice of Mucus + Omeprazole group were pretreated with omeprazole (20 mg/kg, per os). Ethanol administration caused grave lesions of gastric mucosa and a significant decrease of glutathione (GSH) and superoxide dismutase (SOD), catalase, and glutathione reductase (GR) activities. In the animals with mucus or omeprazole pre-administration compared to the Ethanol group, the following were observed: only a small number of hemorrhagic fields, significantly reduced GU index with calculated 73% protection by mucus and 78% protection by omeprazole, and significant recovery of mucosal GSH and SOD and GR activities. In addition, the mucus inhibited Helicobacter pylori growth. Thus, the protective effect of C. aspersum mucus on both gastric mucosa and gastric antioxidant potential in ethanol-induced GU model suggests that it may serve as a good tool for prevention of this disease.

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