Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation

Zuluaga, M.; Letourneur, Didier; Gueguen, Virginie

doi:10.1155/2017/8073798

Cited by 31 publications

(26 citation statements)

References 91 publications

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“…In this regard, the capacity of NLC to amplify antioxidant activity was also shown by Nayyer Karimi et al [ 16 ] using DPPH test to evaluate turmeric-NLC scavenging activity compared to free turmeric extract. Furthermore, these results are supported by those obtained in our previous work showing the enhancing of astaxanthin antioxidant capacity by hydroxypropyl-beta-cyclodextrin complexation [ 34 ].…”

Section: Resultssupporting

confidence: 87%

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

et al. 2018

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Astaxanthin is a xanthophyll carotenoid showing efficient scavenging ability and represents an interesting candidate in the development of new therapies for preventing and treating oxidative stress-related pathologies. However, its high lipophilicity and thermolability often limits its antioxidant efficacy in human applications. Here, we developed a formulation of lipid carriers to protect astaxanthin’s antioxidant activity. The synthesis of natural astaxanthin-loaded nanostructured lipid carriers using a green process with sunflower oil as liquid lipid is presented. Their antioxidant activity was measured by α-Tocopherol Equivalent Antioxidant Capacity assay and was compared to those of both natural astaxanthin and α-tocopherol. Characterizations by dynamic light scattering, atomic force microscopy, and scattering electron microscopy techniques were carried out and showed spherical and surface negative charged particles with z-average and polydispersity values of ~60 nm and ~0.3, respectively. Astaxanthin loading was also investigated showing an astaxanthin recovery of more than 90% after synthesis of nanostructured lipid carriers. These results demonstrate the capability of the formulation to stabilize astaxanthin molecule and preserve and enhance the antioxidant activity.

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Section: Resultssupporting

confidence: 87%

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

et al. 2018

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“…137 Zuluaga recently reported that the generation of ROS induced by stressors (AAPH and t-BuOOH, which are free radical donors that generate a burst of ROS) upregulates PTEN gene expression, which causes cellular apoptosis by deactivating AKT. 138 Conversely, astaxanthin treatment significantly suppressed PTEN expression and reduced both eNOS and Bax gene expression in endothelial cells under oxidative stress. 138 Astaxanthin can activate the PI3K/Akt pathway, protecting against H 2 O 2 -induced oxidative stress through the Nrf2/ARE pathway in ARPE-19 cells.…”

Section: Pi3k/akt Pathwaymentioning

confidence: 98%

“…138 Conversely, astaxanthin treatment significantly suppressed PTEN expression and reduced both eNOS and Bax gene expression in endothelial cells under oxidative stress. 138 Astaxanthin can activate the PI3K/Akt pathway, protecting against H 2 O 2 -induced oxidative stress through the Nrf2/ARE pathway in ARPE-19 cells. 139 Astaxanthin activates the specificity protein 1 (Sp1) and NMDA receptor subunit 1 (NR1) signalling pathway, inhibiting the upregulation and nuclear transfer of Sp1 Figure 3 Proposed mechanism by which astaxanthin inhibits ROS and apoptosis.…”

Section: Pi3k/akt Pathwaymentioning

confidence: 98%

<p>The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss</p>

Nan¹,

Gu²,

Huang³

2019

DDDT

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Emerging evidence of significant hearing loss occurring shortly after cisplatin administration in cancer patients has stimulated research into the causes and treatment of this side effect. Although the aetiology of cisplatin-induced hearing loss (CIHL) remains unknown, an increasing body of research suggests that it is associated with excessive generation of intracellular reactive oxygen species (ROS) in the cochlea. Astaxanthin, a xanthophyll carotenoid, has powerful anti-oxidant, anti-inflammatory, and anti-apoptotic properties based on its unique cell membrane function, diverse biological activities, and ability to permeate the blood-brain barrier. In this review, we summarize the role of ROS in CIHL and the effect of astaxanthin on inhibiting ROS production. We focus on investigating the mechanism of action of astaxanthin in suppressing excessive production of ROS.

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“…Astaxanthin has some a wide range of biological activities such as including antioxidant,anti-inflammatory, anticancer and cardioprotective activities (Wu et al, 2012). Astaxanthin has a strong antioxidant property ( Zuluaga et al,2017). Therefore, In this study, it was aimed to investigate the protective effect of astaxanthin against rat brain injury exposed to cadmium in rats.…”

Section: Introductionmentioning

confidence: 99%

Kadmiyum ile Oksidatif Strese Maruz Kalan Sıçanların Beyin Dokusunda Astaksantinin Etkisi;Biyokimyasal, Histopatolojik Değerlendirme

Akkoyun

Bengü

Ulucan

et al. 2018

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Aim of this study is to evaluate protective impact of Astaxanthin (AST) on rats with experimental brain injury induced with Cadmium (Cd). 32 male Wistar albino rats were divided into four groups as Control, Cadmium, Astaxanthin (AST), Cadmium (Cd)+Astaxanthin (AST). Rat brain tissues were obtained at the end of 30 th day. Malondialdehyde (MDA), glutathione (GSH) levels and superoxide dismutase (SOD) enzyme activities were measured in brain homogenates and histopathological examination was performed. MDA levels were improvement in cadmium administered group (p<0.01) as well as Cd+AST administered group (p<0.05) compared to control group. In addition a substantial reduction Cd+AST group was observed compared to cadmium administered group (p<0.01). GSH level shows a decrease in Cd and Cd+AST groups compared to control (p<0.05). SOD enzyme activity was found significantly lower in Cd and Cd+AST groups compared to control (p<0.01). In addition, increase of SOD in Cd+AST group compared to cadmium group was also found significant (p<0.05). Histopathological findings in the cerebral cortex and hippocampus were different between groups. In the control and AST administered groups, normal histological structure was observed in the brain, while severe lesions were seen in the Cd administered group and in the Cd+AST group only mild degenerative lesions were observed.As a result, elevated MDA level due to Cd administration was attenuated with AST administration. Decreased GSH level and SOD enzyme activity due to Cd administration was increased with AST administration. In addition, AST administration decreased histopathological lesions. Consequently, it is thought that AST may be used for protection against brain oxidative damage due to Cd.Keywords: Astaxanthin, cadmium, oxidative stress.ÖZET: Bu çalışmada, ratlarda kadmiyum (Cd), ile meydana gelen beyin hasarını önlemede astaksantinin (AST), koruyucu etkisinin değerlendirilmesi amaçlandı. 32 adet Winstar albino cinsi rat kontol, Kadmiyum (Cd), Astaksantin (AST), Kadmiyum (Cd)+Astaksantin (AST), olmak üzere dört gruba ayrıldı. 30. Günün sonunda rat beyin dokuları alındı. Beyin doku homojenatında malondialdehit (MDA), Glutatyon (GSH) seviyeleri ve süperoksitdismutaz (SOD) enzim aktivitesi ölçülerek, histopatolojik inceleme yapıldı. Beyin dokusu MDA, düzeyleri değerlendirildiğinde kontrol grubu ile kıyaslandığında Cd uygulaması yapılan grupta (p<0,01) ve yine Cd+AST uygulanan grupta artış (p<0,05) olduğu belirlendi. Cd uygulaması yapılan gruba oranla Cd+AST grubunda görülen azalmanın istatistiksel olarak önemli olduğu belirlenmişdir (p<0,01). GSH düzeyleri değerlendirildiğinde, Cd ve Cd+AST grupları, kontrol grubu ile kıyaslandığında gruplar arasında istatistiksel olarak azalışın olduğu belirlendi (p<0,05). SOD enzim aktivitesi değerlendirildiğinde ise Cd ve Cd+AST gruplarında, kontrol grubuna kıyasla görülen azalışın (p<0,01) istatistiksel olarak önemli olduğu, Cd grubuna oranla, Cd+AST uygulaması yapılan grupta SOD düzeyinde görülen artışın önemli olduğu belirlendi (p<0,05). Hi...

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Oxidative Stress Regulation on Endothelial Cells by Hydrophilic Astaxanthin Complex: Chemical, Biological, and Molecular Antioxidant Activity Evaluation

Cited by 31 publications

References 91 publications

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

<p>The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss</p>

Kadmiyum ile Oksidatif Strese Maruz Kalan Sıçanların Beyin Dokusunda Astaksantinin Etkisi;Biyokimyasal, Histopatolojik Değerlendirme

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