Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Münster, Lukáš; Fojtů, Michaela; Capáková, Zdenka; Muchová, Monika; Musilová, Lenka; Vaculovič, Tomáš; Kuřitka, Ivo; Masařík, Michal; Vı́cha, Jan

doi:10.1016/j.carbpol.2020.117562

Cited by 23 publications

(15 citation statements)

References 47 publications

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“…Note that the decrease in cisplatin uptake can be assigned to various factors, including the altered activity of transport proteins, cisplatin efflux, or apoptosis. − While the encapsulation of 1a by the β-CD initially shows no significant impact on the platinum uptake (likely due to the relatively weak binding of 1a to β-CD, vide supra ), CB7 significantly suppresses the transition of 1a (or 1a_aq ) into cells in vitro . Although some reports suggest improved uptake of platinum metallodrug upon the formation of a supra-/macromolecular assembly, ,, we draw a more pressing conclusion from the obtained results. Platinum uptake is comparable for the tested compounds on the respective cell lines and experimental times; thus, it depends rather weakly on the molecular structure.…”

Section: Results and Discussionmentioning

confidence: 62%

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

et al. 2021

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Platinum-based anticancer drugs are actively developed utilizing lipophilic ligands or drug carriers for the efficient penetration of biomembranes, reduction of side effects, and tumor targeting. We report the development of a supramolecular host–guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host. The host–guest binding and hydrolysis process on the platinum core were investigated in detail by using NMR, MS, X-ray diffraction, and relativistic DFT calculations. The encapsulation process in cucurbit[7]uril unequivocally promotes the stability of hydrolyzed dicationic cis-[PtII(NH3)2(H2O)(NH2-R)]2+ compared to its trans isomer. Biological screening on the ovarian cancer lines A2780 and A2780/CP shows time-dependent toxicity. Notably, the reported complex and its β-cyclodextrin (β-CD) assembly achieve the same cellular uptake as cisplatin and cisplatin@β-CD, respectively, while maintaining a significantly lower toxicity profile.

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Section: Results and Discussionmentioning

confidence: 62%

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

et al. 2021

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“…Three different types of glycosidic linkages are primarily found in plant polysaccharides, including α-(1→6)-D, α-(1→4)-D, and β-(1→4)-D (Table 1). Linear polysaccharides (cellulose and hyaluronate) containing β-(1→4) glycosidic linkages and oxidized at C2 and C3, have a superior overall combination of structural features and can be used to improve drug delivery, including enhancing the efficacy of cisplatin against malignant tumors [85]. Further, different types of polysaccharides exist within the same plant; for example, the polysaccharides, PAC-I, -II, and -III, with various molecular weights and differing monosaccharide compositions, are found in Aloe vera L. [86].…”

Section: 2therapeutic Methodsmentioning

confidence: 99%

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

et al. 2023

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Colorectal cancer (CRC) ranks third and second among the most widespread cancers worldwide and the most common causes of human death due to cancer, respectively. Further, for unknown reasons, numbers of young patients diagnosed with colon cancer has increased. Polysaccharides are important functional phytochemicals reported to have anti-CRC effects. Moreover, CRC development and progression is closely related to the gut microbiome. Although approaches for treating CRC have been the subject of some review papers, research into traditional Chinese medicine (TCM) treatments for CRC and the underlying mechanisms involving polysaccharides have not been reviewed. Here, we reviewed the mechanisms underlying treatment of CRC using TCM polysaccharides, based on the etiology of CRC, and common treatment methods applied. The relationship between intestinal microbes and CRC, the mechanism by which TCM polysaccharides induce CRC cell apoptosis, and how TCM polysaccharides promote immune responses are discussed, as well as TCM polysaccharide use in combination with chemotherapy. TCM polysaccharides provide options for CRC treatment, due to their advantages of having multiple targets, eliciting modest adverse reactions, and wide range of available sources.

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“… 7 These carbohydrate polymers have demonstrated anti-tumor, anti-oxidation, and hypoglycemic functions, making them widely used in medicine, substance growth, and the preparation of chemicals. 8 , 9 , 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Exploring carbohydrate extraction from biomass using deep eutectic solvents: Factors and mechanisms

Liu,

Gao,

Chen

et al. 2023

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Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

Cited by 23 publications

References 47 publications

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

Exploring carbohydrate extraction from biomass using deep eutectic solvents: Factors and mechanisms

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