Oxidizing Action of Neonatal and Maternal Plasma on Reduced Glutathione in vitro

Studies on the Action of Maternal and Neonatal Plasma and Serum on Reduced Glutathione <i>in vitro</i>

“…In the present investiga tion a correlation between maternal and neonatal serum proteins was found in 18 out of 20 infants studied. This correlation could explain the relationship between the oxidizing activity of maternal and neonatal plasma already described [9] and confirmed in the present study. The lack of correlation between serum oxidizing activity and serum albumin level was not unexpected since J o celyn [7] has shown that, when the final concentration of albumin in the incubating medium is above 0.3 g/100 ml, the oxidation of GSH reaches a maximum which is not modified by further increases in albumin concentration.…”

“…The difference in oxidizing activity, between maternal and neona tal plasma, previously described [9], has been confirmed by the pres ent study. Furthermore, our results indicate that this difference is still present 3 days after delivery.…”

“…In previous experiments we have shown that the oxidizing activ ity on G SH in aqueous solution in neonatal plasma at birth is signif icantly less than in maternal plasma [9]. Since these findings may have some relevance to the RBC metabolism in the fetus and in the newborn infant, the present investigation was undertaken to extend the pre vious observations and to clarify the following points:…”

Favism: Current Problems and Investigations

“…Assuming a mean incidence for favism of 30% among G6PD-deficient males, one can calculate that the incidence of haemolytic crisis is 60% for subjects of A and CA phenotype, 35%/for BA and CB subjects, and 20% for G6PD-deficient subjects of phenotype B (Table II) (Jocelyn, 1960;Bottini et al, 1970a) …”

“…In addition to enzymes concerned in the absorption and metabolism of the active substances of Vicia faba, plasma factors which influence the stability of GSH in RBC may have some importance. It is known that such factors do exist (Jocelyn, 1960;Bottini et al, 1970a) but up to now little attention has been paid to their possible role in physiological and pathological conditions. In 1971, Sartori reconsidered his theory on the genetics of favism.…”